Topise 50mg Tablet is a medicine used to treat epilepsy (seizures) and to prevent migraines. It is also used in the treatment of Lennox-Gastaut syndrome (a rare, but severe form of epilepsy that starts in early childhood).

Topise 50mg Tablet may be taken with or without food, preferably at the same time, each day. If you have missed a dose, take it as soon as you remember it and finish the full course of treatment even if you feel better. Stopping the medication suddenly without talking to your doctor may cause an increased frequency of seizures. Your doctor may advise regular monitoring of serum bicarbonate levels while you are taking this medicine.

Some of the common side effects of this medicine include nausea, taste change, fatigue, diarrhea, weight loss, loss of appetite, and memory impairment. It may also cause vision problems like myopia or glaucoma, so it is important to get your eyesight checked before you start the treatment and regularly thereafter. You may experience dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Please consult your doctor if these side effects bother you or do not go away.

Uses of Topise Tablet

Epilepsy
Mania
Epilepsy/Seizures
Lennox–Gastaut syndrome
Migraine
Trigeminal neuralgia
Seizures

Benefits of Topise Tablet

In Epilepsy/Seizures

Topise 50mg Tablet is an anticonvulsant (or anti-epileptic) medicine that works by decreasing the nerve impulses which cause the seizures. By controlling the frequency of seizures, it will help you go about your daily activities with more confidence. It helps reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety.
This medicine is not associated with any physical or psychological dependence (addiction) but it should not be stopped suddenly. It must be taken regularly as prescribed to be effective. Missing doses may trigger a seizure.

In Lennox–Gastaut syndrome

Lennox-Gastaut syndrome (LGS) is a rare but severe form of epilepsy that usually starts in early childhood. Affected children may experience several different types of seizures. Topise 50mg Tablet helps prevent and control these seizures by decreasing the nerve impulses which cause the seizures.

show less

Side effects of Topise Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Topise

Abdominal pain
Diarrhea
Dizziness
Fatigue
Fever
Loss of appetite
Memory impairment
Nausea
Nervousness
Numbness
Psychomotor impairment
Sleepiness
Speech disorder
Taste change
Upper respiratory tract infection
Visual impairment
Weight loss

How to use Topise Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Topise 50mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Topise Tablet works

Topise 50mg Tablet is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Topise 50mg Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Topise 50mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Topise 50mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Topise 50mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Topise 50mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Topise 50mg Tablet may be needed. Please consult your doctor.

Liver

CAUTION

Topise 50mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Topise 50mg Tablet may be needed. Please consult your doctor.

What if you forget to take Topise Tablet?

If you miss a dose of Topise 50mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Topise 50mg Tablet

₹2.62/Tablet

Epitop 50 Tablet

Micro Labs Ltd

₹8.82/tablet

237% costlier

Topamac 50mg Tablet

Janssen Pharmaceuticals

₹26.7/tablet

919% costlier

Topirol 50 Tablet

Sun Pharmaceutical Industries Ltd

₹17.1/tablet

553% costlier

Nextop 50 Tablet

Torrent Pharmaceuticals Ltd

₹19.4/tablet

640% costlier

Topamed 50mg Tablet

Icon Life Sciences

₹16.5/tablet

530% costlier

View all substitutes

Quick tips

Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
Some healthy tips to prevent seizures:
- Practice yoga every day.
- Get enough sleep at nighttime.
- Limit the use of screen time such as mobile/laptop.
- Take your medication on time.
It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
Keep yourself hydrated by drinking plenty of fluids throughout the day while taking Topise 50mg Tablet. This can reduce the risk of kidney stones.
Monitor your weight during treatment with this medicine as it can cause weight gain.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.

Fact Box

Chemical Class

Dioxolopyrans Derivative

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Sodium Channel Modulators- Antiepileptic drugs (AEDs)

Interaction with drugs

Taking Topise with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Medroxyprogesterone acetate (Oral Route) Severe

Concurrent use may increase the risk of breakthrough bleeding and contraceptive failure. It is recommended to use barrier methods (like condoms), IUDs, or a depot for contraceptio... More

Medroxyprogesterone acetate (Oral Route) Severe

Concurrent use may increase the risk of breakthrough bleeding and contraceptive failure. It is recommended to use barrier methods (like condoms), IUDs, or a depot for contraceptio... More

Ulipristal acetate (Oral Route) Severe

Topiramate may reduce the efficacy of Ulipristal acetate. Do not consume Ulipristal acetate with Topiramate. If Ulipristal acetate is essential, ensure a gap of At least 4 weeks a... More

Orlistat (Oral Route) Moderate

Orlistat may reduce efficacy of Topiramate. Watch out for symptoms such as tremors. seizures or impaired coordination and consult your doctor if you experience them. Your doctor m... More

Lithium carbonate (Oral Route) Moderate

Concurrent use may cause a toxic rise in Lithium carbonate levels in the blood. Talk to your doctor if you notice any unusual symptoms.

View all drug interactions

Patient concerns

She has problem of epilepsy from last two years

Dr. Rahul Yadav

Paediatrics

Hello, epilepsy and seizures cannot be treated online without physically examining the child and detailed history.

Left side headache while laughing or coughing for 20 seconds only Pls suggest

Dr. Pushkar Mani

Physician

could be trigeminal neuralgia/ TM joint stifness or migrainerefer to ENT doctor and Neurophysician

I m taking 1.5gm sodium valporate,1.5 levectram, 1gm clobezam then also seizure r their at period of weekly is there alternate treatment in Ayurveda as every time at multiplying the doses at every visit As MRI eeg every tests r normal

Dr. M. K. Ansari

Neurology

not aware of any ayurvedic medications for epilepsy is not my specialization. However you seems to have difficult to control (intractable) seizures plz follow doctors advice deligently for ur own welfare

?? ???? ?????? ?? ?????? ?? ?? ??? encorate Charon 200 500 tablet use krta hu kya iska koi solution h Jisse main completely thk ho jau

Dr. Jyoti Kapoor Madan

Psychiatry

Epilepsy requires regular treatment with anticonvulsants like encorate chrono for at least 3 years of seizure free period after which medicines may be tapered off unless seizures reappear. At present, there are no other effective treatment options.

FAQs

For how long do I need to take Topise 50mg Tablet?

The dose and duration of this medicine will depend on your doctor’s advice. Topise 50mg Tablet does not cure your condition (seizures/migraine) but prevents them from occurring. So, you may have to keep taking it for months or years depending on improvement in your symptoms and side effects that may occur.

Is Topise 50mg Tablet good for anxiety?

Topise 50mg Tablet is not indicated for the treatment of anxiety. Please consult your doctor before taking the medicine.

What are the serious side effects of Topise 50mg Tablet?

Serious side effects of Topise 50mg Tablet are rare. The serious effects of Topise 50mg Tablet may include glaucoma (difficulty in seeing, eye pain, and blurred vision), kidney stones (sharp pain in your sides or lower back), and metabolic acidosis (tiredness, loss of appetite, irregular and faint heartbeat). Other serious side effects of Topise 50mg Tablet could be suicidal thoughts and insufficient sweating (some children taking Topise 50mg Tablet may not sweat enough in hot weather, causing their body temperatures to rise).

I am taking valproic acid for fits. Will Topise 50mg Tablet interfere with the working of valproic acid? Can this combination be taken?

Topise 50mg Tablet does not interfere with the working of valproic acid, but it increases the risk of getting excess levels of ammonia in the blood (hyperammonemia). Increased levels of ammonia in the blood can be dangerous and may cause difficulty in thinking, remembering information, or solving problems. It may also decrease your alertness and make you feel very sleepy with low energy. Immediately inform your doctor if you notice these symptoms. It is important to know that, in rare cases, Topise 50mg Tablet alone can cause hyperammonemia.

Can Topise 50mg Tablet be used in children?

Yes, Topise 50mg Tablet is used for seizures in children more than 2 years of age. However, because of the lack of any reports, this medicine is not recommended to be used in children for migraines.

Since I have started using Topise 50mg Tablet people are saying that I have lost weight. Is it because of Topise 50mg Tablet or something else for which I should get investigated?

It could be due to Topise 50mg Tablet because Topise 50mg Tablet commonly causes weight loss probably due to a decrease in appetite. If you still have any doubts, talk to your doctor who will advise you appropriately.

Show less

Top Neurologists

4.6 ★

4.1 ★

4.2 ★

Dr. Susant Kumar Bhuyan

MBBS, MD, DM

5 ★

Dr. Kapil Agarwal

MBBS, MD, DM

4.8 ★

Want to share the information?

Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Stahl SM, editor. Topiramate. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 669-73.
McNamara JO. Pharmacotherapy of the Epilepsies. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 601.
Porters RJ, Meldrum BS. Antiseizure Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 12.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1380-82.
Topiramate. High Wycombe, Bucks: Janssen-Cilag Ltd.; 1995 [revised 13 Dec. 2017]. [Accessed 22 Jan. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Topiramate. [Updated 2020 Jan 20]. [Accessed 20 Feb. 2020] (online) Available from:
Topiramate. Gurabo, Puerto Rico: Janssen Ortho; 2012. [Accessed 18 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
Topiramate [Prescribing Information]. 2012. Titusville, NJ: Janssen Pharmaceuticals, Inc.; 2009. [Accessed 20 Feb. 2024] (online) Available from:

Marketer details

Name: Arco Pharmaceuticals

Address: Aishwarya Residency, Pragatipuram Extension Dayal Bagh, Near Temple & Park, Agra-282005, Uttar Pradesh, India

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.