Toplac 10gm Syrup is a type of sugar used to treat constipation. It is known as a laxative and makes your stool easier to pass by drawing water into your bowel. It is also used to treat hepatic encephalopathy (a liver disease causing confusion, tremor, decreased level of consciousness).

Toplac 10gm Syrup can be taken with or without food. You should take this medicine as advised by your doctor. Use this medicine regularly to get the maximum benefit and try to take it at the same time(s) each day. Your dose may go up or down depending on how well it is working. Do not take more than you are advised to and, if you miss a dose, do not take an extra one to make up for it. This medicine takes at least 48 hours to work. Talk to your doctor if you are still constipated after 3 days.

The most common side effects are nausea and vomiting. These are usually mild and go away after a couple of days. Occasionally people develop serious side effects including severe diarrhea and electrolyte imbalance. Talk to your doctor straight away if you notice any of these.

Before taking this medicine, you should tell your doctor if you have diabetes or if you are unable to digest milk sugar (lactose intolerant). If you use this medicine over a long period of time, your doctor may want you to have occasional blood tests to check the mineral levels (e.g. potassium and sodium). Do not take other laxative medicines while taking this medicine and check with your doctor if you are pregnant or breastfeeding.

Uses of Toplac Syrup

Constipation
Intestine preparation before any surgery
Treatment of Hepatic encephalopathy

Benefits of Toplac Syrup

In Treatment of Hepatic encephalopathy

Hepatic encephalopathy is a severe liver disease that can cause changes in brain function leading to confusion, tremors (shaking), sleep problems, and loss of consciousness. Toplac 10gm Syrup is thought to work by lowering the level of a substance called ammonia in the blood which has harmful effects on the brain. If taken as prescribed, it can improve your brain function and reduce symptoms associated with hepatic encephalopathy.

Side effects of Toplac Syrup

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Toplac

Abdominal pain
Nausea
Vomiting
Diarrhea

How to use Toplac Syrup

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Toplac 10gm Syrup may be taken with or without food, but it is better to take it at a fixed time.

How Toplac Syrup works

Toplac 10gm Syrup works by drawing water into the intestine through osmosis, which makes the stool soft and easier to pass.

Safety advice

Alcohol

SAFE

Consuming alcohol with Toplac 10gm Syrup does not cause any harmful side effects.

Pregnancy

SAFE IF PRESCRIBED

Toplac 10gm Syrup is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Breast feeding

SAFE IF PRESCRIBED

Toplac 10gm Syrup is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Driving

SAFE

Toplac 10gm Syrup does not usually affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Toplac 10gm Syrup is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Toplac 10gm Syrup may not be needed in these patients. Please consult your doctor.

Liver

SAFE IF PRESCRIBED

Toplac 10gm Syrup is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Toplac 10gm Syrup may not be needed in these patients. Please consult your doctor.

What if you forget to take Toplac Syrup?

If you miss a dose of Toplac 10gm Syrup, skip it and continue with your normal schedule. Do not double the dose.\n

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Toplac 10gm Syrup

₹109.0/Syrup

Gentalose Syrup

Biocon

₹79/syrup

28% cheaper

Swiftolac Syrup

Shreya Life Sciences Pvt Ltd

₹193.73/syrup

78% costlier

Swiftolac Syrup

Shreya Life Sciences Pvt Ltd

₹111.58/syrup

2% costlier

Lactovax 10gm Syrup

Fibovil Pharmaceuticals Pvt Ltd

₹256/syrup

135% costlier

Evacmore L 10gm Syrup

Alter Ego Pharmaceuticals

₹215/syrup

97% costlier

View all substitutes

Quick tips

Toplac 10gm Syrup is used in the treatment of constipation and hepatic encephalopathy.
It should preferably be taken at bedtime as it requires 6 to 8 hours to show effect.
It is usually taken once a day as needed for up to 2 weeks. Take it exactly as prescribed by the doctor.
Take it atleast 2 hours after taking other medicines, as it may interfere with the absorption of other medicines.
Inform your doctor if you have a history of stomach disorders such as appendicitis or a blockage in your bowel.
Some healthy tips to prevent constipation from happening:
- Eat more fiber in your diet. Recommended daily intake is 20-35g
- Drink 8-10 glasses of water per day
- Exercise regularly at least 3 times per week
- Do not hold in stool as that can worsen bowel issues
Toplac 10gm Syrup is used for the treatment of constipation.
Some healthy tips to prevent constipation from happening:
- Eat more fiber in your diet. Recommended daily intake is 20-35g
- Drink 8-10 glasses of water per day
- Exercise regularly at least 3 times per week
- Do not hold in stool as that can worsen bowel issues
Take it atleast 2 hours after taking other medicines, as it may interfere with the absorption of other medicines.
It should preferably be taken at bedtime as it requires 6 to 8 hours to show effect.
It is usually taken once a day as needed for up to 2 weeks. Take it exactly as prescribed by the doctor.
Inform your doctor if you have a history of stomach disorders such as appendicitis or a blockage in your bowel.

Fact Box

Chemical Class

Synthetic Disaccharide

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

Osmotic Laxatives / Purgatives

Interaction with drugs

Taking Toplac with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Acenocoumarol (Oral Route) Moderate

Lactulose may increase the effect of Acenocoumarol. Inform your doctor if you notice any signs of bleeding (bruising, bleeding gums, blood in stool/vomit/urine).

Warfarin (Oral Route) Moderate

Lactulose may increase the effect of Warfarin. Inform your doctor if you notice any signs of bleeding (bruising, bleeding gums, blood in stool/vomit/urine).

Mesalazine (Oral Route) Mild

View all drug interactions

Patient concerns

hepatic encephalopathy fro 12 October

Dr. Saurav Arora

Homeopathy

Dear sir as your case is a chronic case it requires long case taking, examination and regular follow up, therefore, please visit a homeopath so that he can examine you and guide you accordingly.

Jaundice liver cirrhosis. Hepatic encephalopathy and ascites not edema with Sodium 107. Can we use tolvaptone?

Dr. Gurpreet Singh

Physician

Sir consult a hepatologist

FAQs

How long does it take for Toplac 10gm Syrup to work?

It takes about 2-3 days to see the benefits of the treatment. Talk to your doctor if you feel constipated even after 3 days of taking Toplac 10gm Syrup.

What is Toplac 10gm Syrup used for?

Toplac 10gm Syrup is used to treat constipation which is presented as infrequent bowel movements, hard and dry stools. It is also used in patients with hepatic encephalopathy which is a serious liver problem causing confusion, tremors and decreased level of consciousness.

Is Toplac 10gm Syrup a laxative?

Yes, Toplac 10gm Syrup is a laxative which softens the stools by pulling in water from the body to the large intestine. It is also used to reduce the amount of ammonia in the blood of patients with liver disease.

What are the side effects of taking Toplac 10gm Syrup?

Toplac 10gm Syrup very commonly causes diarrhea, flatulence, nausea, vomiting and abdominal pain. Diarrhea and abdominal pain occur due to a high dose. In such cases, the dose should be reduced. Flatulence may occur during the first few days of treatment and may disappear after sometime. This medicine may also cause electrolyte imbalance. However, this is an uncommon side effect.

Is it okay to take Toplac 10gm Syrup every day?

You should take Toplac 10gm Syrup for as long as advised by your doctor. You may also take it for as long as constipation lasts, which may be up to a week. For hepatic encephalopathy, the treatment may be longer, even several months.

Who should not be given Toplac 10gm Syrup?

Toplac 10gm Syrup should not be given to patients who are allergic to it or are intolerant to lactose (cannot process lactose). It should also be avoided in patients having galactosemia, a rare health problem where the body cannot process galactose.

Can I take other laxatives along with Toplac 10gm Syrup?

Usually, one laxative is sufficient to relieve constipation. In case you need more, your doctor may advise you to take one more laxative along with Toplac 10gm Syrup. The risk of side effects is more with two laxatives.

What if I take more than the recommended dose of Toplac 10gm Syrup?

Taking more than the recommended dose of Toplac 10gm Syrup may cause abdominal pain, electrolyte imbalance and diarrhea, which may last for a couple of days.

How should Toplac 10gm Syrup be taken?

You should take the prescribed amount in the measuring cup or spoon that is provided with the medicine. You can take it with water or fruit juice if you find it very sweet. Drink plenty of water for better results. Swallow it as soon as you keep it in mouth to prevent tooth decay which can occur if you take it for a longer time.

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References

Sharkey KA, Wallace JL. Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1332.
McQuaid KR. Drugs Used in the Treatment of Gastrointestinal Diseases. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 1079.
Lactulose. Maidenhead, Berkshire: Intrapharm Laboratories Limited; 2015 [revised 12 Jan. 2017]. [Accessed 27 Mar. 2019] (online) Available from:
Drugs.com. Lactulose. [Accessed 27 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:

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