Tosgyl 400mg Tablet is an antibiotic medicine that helps your body fight infections caused by bacteria and parasites. It is used to treat infections of the liver, stomach, intestines, vagina, brain, heart, lungs, bones, and skin.

Tosgyl 400mg Tablet helps prevent an infection after surgery. It is also used in the treatment of dental infections, leg ulcers, and pressure sores. This medicine is best taken after eating some food. It should be taken at the same time each day to get the most benefit. The amount you are advised will depend on what you are being treated for and how bad it is, but you should take this antibiotic exactly as prescribed by your doctor. Your symptoms may get better after a short time but do not stop taking it until you have finished a full course of treatment, even if you feel well. If you stop taking it early, some bacteria may survive, and the infection may come back. Do not drink alcohol while taking this medicine and for a few days after stopping it. Otherwise, you may get unpleasant side effects like nausea, vomiting, and stomach pain.

The most common side effects of this medicine are headache, dryness in the mouth, nausea, and a slight metallic taste in the mouth. These are usually mild but let your doctor know if they bother you or last more than a few days. You can try using sugarless candies or lozenges to overcome any dryness or metallic taste in the mouth.

Before using this medicine, inform your doctor if you are allergic to any medicine or have any kidney or liver problems or any disease of the nervous system. If you are pregnant or breastfeeding, inform your doctor before taking this medicine.

Uses of Tosgyl Tablet

Treatment of Bacterial infections
Treatment of Parasitic infections

Benefits of Tosgyl Tablet

In Treatment of Bacterial infections

Tosgyl 400mg Tablet is a versatile antibiotic medicine that can be used to treat many different infections caused by bacteria. These include infections of the blood, brain, lungs, bones, joints, urinary tract, stomach, and intestines. It can also be used to treat gum ulcers and other dental infections (abscesses), leg ulcers, and pressure sores. It works by stopping the growth of the bacteria causing the infection.

This medicine usually makes you feel better quite quickly. However, you should continue taking it as long as it is prescribed even when you feel better, to make sure that all bacteria are killed and do not become resistant. This medicine is generally safe to use while pregnant or breastfeeding, but you should ask your doctor.

In Treatment of Parasitic infections

Tosgyl 400mg Tablet is an antibiotic medicine that helps treat many parasitic infections such as amoebic dysentery. It works by stopping the growth of parasites causing the infection. This medicine usually makes you feel better quite quickly. However, you should continue taking it as long as it is prescribed even when you feel better, to make sure that all parasites are killed and do not become resistant. This medicine is generally safe to use while pregnant or breastfeeding, but you should ask your doctor.

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Side effects of Tosgyl Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Tosgyl

Headache
Dryness in mouth
Nausea
Metallic taste

How to use Tosgyl Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tosgyl 400mg Tablet is to be taken with food.

How Tosgyl Tablet works

Tosgyl 400mg Tablet is an antibiotic. It kills the bacteria and other microorganisms that cause infections by damaging their DNA.

Safety advice

Alcohol

UNSAFE

Consuming alcohol while taking Tosgyl 400mg Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).

Pregnancy

SAFE IF PRESCRIBED

Tosgyl 400mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Breast feeding

CAUTION

Tosgyl 400mg Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
If a single dose of Tosgyl 400mg Tablet is used, it is recommended to hold breastfeeding for 12-24 hours to allow the removal of the drug.

Driving

UNSAFE

Tosgyl 400mg Tablet may cause side effects which could affect your ability to drive.
Tosgyl 400mg Tablet may make you feel sleepy, dizzy, confused. You may have hallucinations, fits (convulsions) or temporary eyesight problems (such as blurred or double vision) affecting your ability to drive.

Kidney

SAFE IF PRESCRIBED

Tosgyl 400mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Tosgyl 400mg Tablet is recommended.
Patients undergoing kidney dialysis should take this medicine after the dialysis treatment.

Liver

CAUTION

Tosgyl 400mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Tosgyl 400mg Tablet may be needed. Please consult your doctor.

What if you forget to take Tosgyl Tablet?

If you miss a dose of Tosgyl 400mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Tosgyl 400mg Tablet

₹0.58/Tablet

Metron 400mg Tablet

Alkem Laboratories Ltd

₹1.53/tablet

164% costlier

Metrogyl 400 Tablet

J B Chemicals and Pharmaceuticals Ltd

₹1.7/tablet

193% costlier

Flagyl 400 Tablet

Abbott

₹1.67/tablet

188% costlier

Aristogyl 400 Tablet

Aristo Pharmaceuticals Pvt Ltd

₹1.7/tablet

193% costlier

Metrogyl 400 Tablet

J B Chemicals and Pharmaceuticals Ltd

₹1.67/tablet

188% costlier

View all substitutes

Quick tips

Tosgyl 400mg Tablet treats infections caused by bacteria and parasites.
It may cause side effects like nausea, stomach upset, and a metallic taste in the mouth.
Tosgyl 400mg Tablet used in a high dose or for a prolonged time increases the risk of side effects such as nerve damage. Take it only as prescribed by your doctor.
Do not drink alcohol during or for 2-3 days after treatment with this medicine. You may develop nausea, vomiting, flushing and headache.
Inform your doctor if you have liver disease. Your dose may need to be adjusted in severe liver disease.

Fact Box

Chemical Class

Nitroimidazole

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

5-Nitroimidazole (Antiprotozoal & Antibacterial)

Interaction with drugs

Taking Tosgyl with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Phenobarbitone (Oral Route) Moderate

Phenobarbitone may increase the metabolism of Metronidazole. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Phenobarbitone (Injection Route) Moderate

Phenobarbitone may increase the metabolism of Metronidazole. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Primidone (Oral Route) Moderate

Primidone may increase the metabolism of Metronidazole. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Phenytoin (Oral Route) Moderate

Concurrent use may lead to toxicity of Phenytoin. Phenytoin may increase the metabolism of Metronidazole. watch out for symptoms such as blurred vision, sedation, drowsiness, impai... More

Disulfiram (Oral Route) Moderate

Disulfiram may reduce blood levels of active form of Metronidazole. Do not consume Metronidazole with Disulfiram. If concurrent use is essential, watch out for symptoms such as co... More

View all drug interactions

Patient concerns

Scar on face due to bacterial infections

Dr. Atul Jain

Dermatology

Pic is not clear, plz visit for proper opinion

I have a history of recurring yeast and bacterial vaginosis infections.

Dr. Sonu Balhara Ahlawat

Obstetrics and Gynaecology

Tab metrogyl 500 mg twice a day x 5 days and tab fluconazole 150 mg three doses alternate days

User feedback

What are you using Tosgyl Tablet for?

Others

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FAQs

How long does Tosgyl 400mg Tablet take to work?

Usually, Tosgyl 400mg Tablet starts working within 1 hour of its ingestion. However, it may take around 2-3 days to make you feel better while taking Tosgyl 400mg Tablet. If you do not experience any significant reduction in your symptoms, consult your doctor.

Can I drink alcohol while using Tosgyl 400mg Tablet?

No, avoid drinking alcohol while taking Tosgyl 400mg Tablet. Moreover, you should avoid alcohol even after 3 days of finishing the complete course. Drinking alcohol can cause an unpleasant reaction (disulfiram like reaction) with symptoms such as stomach pain, nausea, vomiting, headache, flushing or redness of the face.

Can the use of Tosgyl 400mg Tablet cause metallic taste?

Yes, Tosgyl 400mg Tablet may cause a temporary metallic taste. This metallic taste can be reduced by staying hydrated, brushing teeth after the meals and chewing sugar-free gum or mints.

What if I take more than the recommended dose of Tosgyl 400mg Tablet?

If you have taken Tosgyl 400mg Tablet in excess (more than the recommended dose), immediately contact your doctor or report to the nearest hospital. Overdose of Tosgyl 400mg Tablet may cause loss of appetite, metallic taste, headache, dizziness, insomnia or drowsiness.

Can I stop taking Tosgyl 400mg Tablet when I feel better?

No, do not stop taking Tosgyl 400mg Tablet and complete the full course of treatment even if you feel better. Your symptoms may improve before the infection is completely cured. Hence, if you stop taking the medicine before completing the course, your infection may come back. Consult your doctor before you stop taking Tosgyl 400mg Tablet and follow their advice.

What if there is no improvement after using Tosgyl 400mg Tablet?

Inform your doctor if you did not feel better after completing the full course of treatment. Also, inform him/her if your symptoms are getting worse during the treatment.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Phillips MA, Stanley SL Jr. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1428-30.
Chambers HF, Deck DH. Miscellaneous Antimicrobial Agents; Disingectants, Antiseptics, & Sterilants. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 877.
Rosenthal PJ. Antiprotozoal Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 912-14.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 905-910.
Metronidazole. New York, New York: Pfizer; 2013. [Accessed 29 Mar. 2019] (online) Available from:
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-98. [Accessed 29 Mar. 2019] (online) Available from:

Marketer details

Name: TOSC International Pvt Ltd

Address: H-1429 ,1441 DSIDC Industrial Area Narela Delhi-110040 , INDIA

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.