Trental 400 Tablet PR
Prescription RequiredProduct introduction
Trental 400 Tablet PR is used to treat peripheral vascular disease (poor circulation to the arms and legs) and intermittent claudication (pain on walking or at rest caused by poor circulation to the legs). It works by increasing the blood flow to the arms and legs.
Take Trental 400 Tablet PR exactly as prescribed by your doctor. It works best when taken regularly, as it helps improve blood flow over time rather than giving instant relief. Do not skip doses or stop the medicine on your own, even if symptoms start to improve, as this may reduce its benefit. If you miss a dose, take it as soon as you remember unless it is almost time for the next dose, do not double the dose.
Common side effects of Trental 400 Tablet PR may include flushing, headache, dizziness, drowsiness, nervousness, tremor, and sleep disturbances such as insomnia. Some people may experience stomach-related discomfort like abdominal pain, bloating, indigestion (dyspepsia), nausea, vomiting, or diarrhea. Blurred vision may also occur. These effects are usually mild and settle as the body adjusts to the medicine. Consult your doctor if any side effect persists, worsens, or becomes bothersome.
Trental 400 Tablet PR should be used with caution in people who have heart disease, low blood pressure, bleeding disorders, or a history of stroke. Inform your doctor if you have liver or kidney problems, as dose adjustment may be required. It is not recommended for patients with recent bleeding, recent heart attack, or allergy to methylxanthines (such as caffeine or theophylline). Use during pregnancy or breastfeeding should be only if clearly advised by a doctor.
Uses of Trental Tablet PR
- Peripheral vascular disease
- Intermittent claudication
Benefits of Trental Tablet PR
In Peripheral vascular disease
Peripheral vascular disease refers to the condition of disturbed blood circulation in blood vessels. Trental 400 Tablet PR prevents blood from clotting inside the veins and arteries. This helps the blood flow freely around your body thereby preventing a heart attack or stroke (or deep vein thrombosis or pulmonary embolism). It helps prevent the formation of blood clots and also prevents the existing ones from growing bigger in size. Make appropriate lifestyle changes (such as eating healthy and staying active) to maximize the effectiveness of this medicine.
In Intermittent claudication
Intermittent claudication refers to muscle pain on mild exertion (ache, cramp, numbness or sense of fatigue), classically in the calf muscle, which occurs during exercise or even walking, and it gets better with a short period of rest. Trental 400 Tablet PR helps relieve this pain in the legs that is caused due to disturbed blood supply in the legs. It helps prevent formation of blood clots, improves blood flow and maintains free flowing of blood in your body.
Side effects of Trental Tablet PR
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Trental
- Bloating
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Nausea
- Stomach discomfort
- Vomiting
- Dizziness
- Angina (heart related chest pain)
- Arrhythmia (irregular heartbeats)
- Indigestion
- Nervousness
- Drowsiness
- Headache
- Insomnia (difficulty in sleeping)
- Tremors
- Blurred vision
How to use Trental Tablet PR
Use it as advised by your doctor or check the label for directions before use. Trental 400 Tablet PR should be taken with or after food.
How Trental Tablet PR works
Trental 400 Tablet PR is a peripheral vasodilator. It works by decreasing the thickness (viscosity) of blood, allowing it to pass more easily through the blood vessels. This effect is beneficial in peripheral vascular disease, where the blood vessels in the arms and legs are narrowed.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Trental 400 Tablet PR. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Trental 400 Tablet PR is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding
CONSULT YOUR DOCTOR
Trental 400 Tablet PR may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving
SAFE
Trental 400 Tablet PR does not usually affect your ability to drive.
Kidney
CAUTION
Trental 400 Tablet PR should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver
CAUTION
Trental 400 Tablet PR should be used with caution in patients with liver disease. Dose adjustment may be needed.
What if you forget to take Trental Tablet PR?
If you miss a dose of Trental 400 Tablet PR, skip it and continue with your normal schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- Take it as per dose and duration suggested by your doctor.
- Do not drive or perform activities that require mental focus until you know how Trental 400 Tablet PR affects you.
- Your doctor may get regular blood tests done to monitor liver function while taking this medicine.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
- Take it with food, preferably at the same time everyday to avoid missing a dose.
Fact Box
Chemical Class
Xanthine derivative
Habit Forming
No
Therapeutic Class
CARDIAC
Action Class
Hemorrheologic Agents
Interaction with drugs
Taking Trental with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Ciprofloxacin may raise blood levels of Pentoxifylline.
Concurr
If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.
Concurrent use may increase the risk of bleeding.
Do not consume Aminophylline with Pentoxifylline. If concurrent use is essential, watch out for symptoms such as nausea, palpitations or headaches and consult your doctor if you ex
If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Ciprofloxacin may raise blood levels of Pentoxifylline.
Concurr
Do not consume Aminophylline with Pentoxifylline. If concurrent use is essential, watch out for symptoms such as nausea, palpitations or headaches and consult your doctor if you ex
Patient concerns
User feedback
Patients taking Trental 400 Tablet PR
Twice A Day
80%
Once A Day
20%
What are you using Trental Tablet PR for?
Peripheral va*
58%
Others
21%
Intermittent *
21%
*Peripheral vascular disease, Intermittent claudication
How much was the improvement?
Average
40%
Poor
32%
Excellent
28%
What were the side-effects while using Trental 400 Tablet PR?
No Side Effec*
48%
Nausea
20%
Agitation
8%
Bloating
4%
Pain in anal *
4%
*No Side Effect, Pain in anal region
How do you take Trental Tablet PR?
With food
95%
With or witho*
5%
*With or without food
Please rate Trental 400 Tablet PR on price
Average
46%
Expensive
30%
Not Expensive
24%
FAQs
What is Trental 400 Tablet PR used for?
Trental 400 Tablet PR is used to improve blood flow in people with circulation problems, especially those with peripheral arterial disease, which can cause leg pain or cramps when walking. It works by making the blood less thick and easier to flow through small blood vessels.
How does Trental 400 Tablet PR help with poor blood circulation?
Trental 400 Tablet PR improves blood flow by reducing blood viscosity (thickness), and helping red blood cells move more easily through narrow blood vessels. This helps increase oxygen delivery to affected areas, reducing pain and discomfort during walking.
Who should not take Trental 400 Tablet PR?
Individuals should not take Trental 400 Tablet PR if they have had recent bleeding in the brain or eyes, or if they are allergic to pentoxifylline, or similar substances like caffeine, or theophylline. Always inform your doctor about your full medical history before starting this medicine.
Can Trental 400 Tablet PR cause serious allergic reactions?
Yes, although they are rare, serious allergic reactions of Trental 400 Tablet PR include swelling, difficulty breathing, or severe rash. If you notice these symptoms, stop the medicine immediately and seek urgent medical help.
Is Trental 400 Tablet PR safe for people with heart problems?
Trental 400 Tablet PR has been used in people with heart and circulation issues, but in some cases, it may cause chest pain, low blood pressure, or irregular heartbeat. If you have heart disease, your doctor will monitor you closely while on this medicine.
Does Trental 400 Tablet PR increase the risk of bleeding?
Trental 400 Tablet PR may increase bleeding risk, especially if you have bleeding disorders, stomach ulcers, recent surgery, or are taking other blood-thinning medicines. Your doctor may check your blood counts, bleeding time, and clotting time regularly.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Katzung BG, Chatterjee K. Vasodilator & the Treatment of Angina Pectoris. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 205.
- Gersh BJ, Opie LH. Which Therapy for Which Condition? In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. p. 528.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1089-90.
- Pentoxifylline. Guildford, Surrey: SANOFI; 2002 [revised 25 May 2016]. [Accessed 25 Jan. 2019] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Pentoxifylline. [Updated 2018 Oct 31]. [Accessed 19 Feb. 2020] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
- Pentoxifylline [Patient Information Leaflet]. Ankleshwar: Gujarat: Sanofi India Limited; 2015. [Accessed 06 Apr. 2024] (online) Available from:
- Memorial Sloan Kettering Cancer Center; 2022. [Accessed 02 Feb. 2026] (online). Available from:
- Pentoxifyllin. Burbank, CA: Bryant Ranch Prepack; 2025. [Accessed 02 Feb. 2026] (online). Available from:
Marketer details
Name: Sanofi India Ltd
Address: Sanofi House, CTS No.117-B, L&T Business Park, Saki Vihar Road, Powai, Mumbai 400072
Country of origin: India
Expires on or after: August, 2028
A licensed vendor partner from your nearest location will deliver Trental 400 Tablet PR. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Expires on or after: August, 2028
A licensed vendor partner from your nearest location will deliver Trental 400 Tablet PR. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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MRP₹85.68 10% OFF
₹77.2
Inclusive of all taxes
15.0 Tablet pr in 1 strip
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