Trexo 15mg Tablet
Prescription Required
Product introduction
Trexo 15mg Tablet is a medicine used for the treatment of cancer in various parts of the body. It is also used to treat rheumatoid arthritis, severe and uncontrolled psoriasis, and Crohn’s disease. It works by slowing the growth of abnormal cells and reducing immune system activity in autoimmune conditions.
Trexo 15mg Tablet may be used alone or in combination with other medicines. You should take it exactly as your doctor has advised. Taking too much of it can cause serious side effects. It may take several weeks or months for you to see or feel the benefits, but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine are ulcerative stomatitis, hair loss, low blood cell count, increased liver enzymes, nausea, and abdominal distress. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects.
Trexo 15mg Tablet may lower your ability to fight infections and lead to problems with your blood, liver, or kidneys. Your doctor may perform several tests, such as blood tests, X-rays, and physical examinations, both before and during the treatment with this medicine to check for these problems.
Before taking it, tell your doctor if you have problems related to the stomach, liver, or kidneys, or are taking any medicines to treat infections. Many other medicines can affect or be affected by this medicine, so let your doctor know about all your medications. This medicine is not recommended during pregnancy or while breastfeeding, as it may harm the baby. You should avoid consuming alcohol while taking this medicine, as it may increase your risk of liver damage.
Uses of Trexo Tablet
Benefits of Trexo Tablet
In Treatment of Cancer
Trexo 15mg Tablet works by slowing the growth of cancer cells in the body. It is used to treat a wide range of cancers, such as acute leukemias, non-Hodgkin’s lymphoma, and solid tumors found in the breast, lung, bladder, head, and neck, as well as cervical, ovarian, and testicular cancer. It may be given alone or in combination with other medicines.
In Treatment of Rheumatoid arthritis
Trexo 15mg Tablet is typically used to treat severe rheumatoid arthritis when other treatments have not been effective. As a second-line treatment, it works by suppressing the immune system, which helps reduce inflammation, pain, stiffness, and improves joint function. Follow your doctor’s instructions carefully, taking it exactly as prescribed, and for the full duration. It may take several months to show full effects. Do not take more than the prescribed dose.
In Treatment of Psoriasis
Trexo 15mg Tablet may be prescribed for severe psoriasis when other treatments have not worked. Psoriasis causes skin cells to grow too quickly, and Trexo 15mg Tablet works by slowing down the rapid cell turnover. Take it as directed by your doctor, and for the full prescribed course to achieve the best results. It may take several months to see the full benefits. Avoid alcohol during treatment and ensure you stay hydrated by drinking plenty of water.
In Treatment of Crohn’s disease
Crohn’s disease is a chronic (long-term) inflammatory disease of the intestines. The most common symptoms are diarrhea and pain in the abdomen. Trexo 15mg Tablet helps reduce the inflammation, relieve the symptoms, and prevent them from coming back.
Side effects of Trexo Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Trexo
- Nausea
- Abdominal pain
- Ulcerative stomatitis
- Decreased blood cells (red cells, white cells, and platelets)
How to use Trexo Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Trexo 15mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Trexo Tablet works
Trexo 15mg Tablet inhibits enzymes (dihydrofolate reductase), prevents cell division, and leads to anti-inflammatory actions. Trexo 15mg Tablet kills cancer cells by preventing them from making DNA. Trexo 15mg Tablet can help control psoriasis by retarding the production of skin cells and suppressing inflammation. Trexo 15mg Tablet may treat rheumatoid arthritis by suppressing the immune system, preventing it from attacking the body's cells. This helps reduce the inflammation that causes swollen and stiff joints in rheumatoid arthritis or damage to the intestine in Crohn's disease.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Trexo 15mg Tablet.
Pregnancy
UNSAFE
Trexo 15mg Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding
UNSAFE
Trexo 15mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
CONSULT YOUR DOCTOR
It is not known whether Trexo 15mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
CAUTION
Trexo 15mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Trexo 15mg Tablet may be needed. Please consult your doctor.
Regular monitoring of kidney function test is advised while you are taking this medicine.
Regular monitoring of kidney function test is advised while you are taking this medicine.
Liver
CAUTION
Trexo 15mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Trexo 15mg Tablet may be needed. Please consult your doctor.
What if you forget to take Trexo Tablet?
If you miss a dose of Trexo 15mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
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For informational purposes only. Consult a doctor before taking any medicines.
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Quick tips
- Drink plenty of liquids to stay hydrated while taking this medication.
- Take folic acid if advised by your doctor. This will help lessen the side effects of this medicine.
- Trexo 15mg Tablet may take from weeks to months for Trexo 15mg Tablet to work. Keep taking the medication as prescribed.
- Your doctor may get regular blood tests done to monitor your kidney function, liver function, and the level of blood cells in your blood.
- Avoid drinking alcohol while taking this medicine, as it may increase the risk of side effects.
Fact Box
Chemical Class
Glutamic Acid Derivative
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Antimetabolite- Methotrexate
Interaction with drugs
Taking Trexo with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Do not use Methotrexate with Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted). If essential, please consult your doctor. Methotrexate may reduce efficacy of Herpes Zoster
Please consult with your doctor. Doctor may monitor kidney and liver function.
Concurrent use may increase the risk of serious side effects of Methotrexate.
Do not consume Filgrastim from 24 hours before or 24 hours after taking Methotrexate. Please consult with your doctor. Methotrexate may reduce the efficacy of Filgrastim.
Avoid concurrent use, please consult with your doctor.
Concurrent use may cause serious liver dysfunction.
Please consult with your doctor. Doctor may monitor kidney and liver function.
Concurrent use may increase the risk of serious side effects of Methotrexate.
Patient concerns
FAQs
Can Trexo 15mg Tablet cause mouth ulcers?
Yes, Trexo 15mg Tablet can cause a sore mouth and mouth ulcers as side effects in some cases. Taking folic acid along with Trexo 15mg Tablet may help in reducing the ulcers. Ask your doctor if the dose can be reduced, as dose reduction may further help in reducing the ulcers.
Why do I have to take folic acid with Trexo 15mg Tablet?
Folic acid is required to make new cells in the body, and Trexo 15mg Tablet decreases the folic acid levels in the body. Folic acid can help reduce some of the side effects of Trexo 15mg Tablet, such as mouth ulcers, hair loss, nausea, heartburn, abdominal pain, fatigue, anemia, and liver problems.
Why do I need to take regular blood tests while taking Trexo 15mg Tablet?
Regular blood tests will help your doctor to check your response to Trexo 15mg Tablet and monitor you for side effects. You will need to regularly check your liver function and your blood counts (white blood cells, red blood cells, and platelets). Your doctor may also order additional tests depending on the results.
Can Trexo 15mg Tablet use make me more prone to infections?
Trexo 15mg Tablet may decrease the activity of your immune system. As a result, you may develop serious infections. There have been rare reports that suggest the occurrence of serious lung infections with the use of Trexo 15mg Tablet. If you have an active infection, Trexo 15mg Tablet should be used with extreme caution.
Can Trexo 15mg Tablet affect fertility?
Yes, Trexo 15mg Tablet may affect fertility in both males and females. It may cause a decrease in sperm count in males and menstrual disturbances in females. No need to worry; these effects are reversible and disappear once the therapy is discontinued.
What to do if I am planning to become pregnant and my husband is taking Trexo 15mg Tablet?
You should avoid pregnancy if your husband is taking Trexo 15mg Tablet. Also, it is advised that pregnancy should be further avoided for a minimum of 3 months after the therapy, as it can lead to serious fetal abnormalities.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 944-46.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 887-90.
- Methotrexate [Prescribing Information]. Eatontown, NJ: West-Ward Pharmaceuticals Corp.; 2020. [Accessed 19 Apr. 2023] (online) Available from:
- Methotrexate [Product Label]. New York, NY: Pfizer Inc.; 2022. [Accessed 19 Apr. 2023] (online) Available from:
- Methotrexate [Drug Label]. Sandton, South Africa: Pfizer Laboratories (Pty) Ltd.; 2022 [Accessed 19 Apr. 2023] (online) Available from:
- Walfish AE, Companioni RA. Drugs for Inflammatory Bowel Disease. [Updated Sep. 2022]. [Accessed 19 Apr. 2023] (online) Available from:
- Crohn's & Colitis, UK. Methotrexate [Information Sheet]. [Accessed 19 Apr. 2023] (online) Available from:
- Methotrexate [Prescribing Information]. Berkeley Heights, NJ: Hikma Pharmaceuticals USA Inc.; 2023. [Accessed 26 Feb. 2025] (online) Available from:
Marketer details
Name: Indiabulls pharmaceutical ltd
Address: Indiabulls Pharmaceuticals Limited is M – 62 & 63, First Floor, Connaught Place, New Delhi – 11000
Country of origin: India
The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.
The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.
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Question 1
What are you using this medicine for?
Cancer
Rheumatoid arthritis
Psoriasis
Crohn’s disease
Others