Trypentin AT 300mg/10mg Tablet is a combination medicine used for the treatment of neuropathic pain. It works by increasing the level of chemical messengers in the brain. This helps in regulating the mood and stopping the movement of pain signals from nerves to the brain.

Trypentin AT 300mg/10mg Tablet is taken by mouth with or without food, preferably at bedtime. It is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of the treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to the doctor as it may increase the seizure frequency and can be life-threatening in some cases. Avoid taking antacids with this medicine as antacids make it harder for your body to absorb this medicine.

Some common side effects of this medicine are constipation, difficulty in urination, weight gain, and dryness in mouth. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may cause weight gain and to control it, you should exercise regularly and take a balanced diet.

Before taking this medicine let your doctor know if you suffer from kidney or liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Uses of Trypentin AT Tablet

Neuropathic pain

Benefits of Trypentin AT Tablet

In Neuropathic pain

Trypentin AT 300mg/10mg Tablet is a combination of medicines used to treat long-lasting (chronic) pain caused by nerve damage due to diabetes, shingles, or spinal cord injury. It reduces pain and its associated symptoms such as mood changes, sleep problems, and tiredness. It is thought to work by interfering with pain signals that travel through the damaged nerves and the brain.
Trypentin AT 300mg/10mg Tablet regularly will improve your physical and social functioning and overall quality of life. It takes a few weeks to work so you need to take it regularly even if you feel it is not doing any good. Once your symptoms have gone you should still keep taking the medicine until your doctor advises you to stop.

Side effects of Trypentin AT Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Trypentin AT

Constipation
Difficulty in urination
Weight gain
Sleepiness
Dizziness
Tiredness
Uncoordinated body movements
Increased heart rate
Orthostatic hypotension (sudden lowering of blood pressure on standing)
Blurred vision
Dryness in mouth

How to use Trypentin AT Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Trypentin AT 300mg/10mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Trypentin AT Tablet works

Trypentin AT 300mg/10mg Tablet is a combination of two medicines: Gabapentin and Amitriptyline. Gabapentin is an alpha 2 delta ligand which decreases the pain by modulating calcium channel activity of the nerve cells. Amitriptyline is a tricyclic antidepressant which increases the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain. Together, they relieve neuropathic pain (pain from damaged nerves).

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Trypentin AT 300mg/10mg Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Trypentin AT 300mg/10mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Trypentin AT 300mg/10mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Trypentin AT 300mg/10mg Tablet may cause side effects which could affect your ability to drive.
Trypentin AT 300mg/10mg Tablet may impair your alertness which may affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Trypentin AT 300mg/10mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Trypentin AT 300mg/10mg Tablet may not be needed in these patients. Please consult your doctor.

Liver

CAUTION

Trypentin AT 300mg/10mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Trypentin AT 300mg/10mg Tablet may be needed. Please consult your doctor.
Use of Trypentin AT 300mg/10mg Tablet is not recommended in patients with severe liver disease.

What if you forget to take Trypentin AT Tablet?

If you miss a dose of Trypentin AT 300mg/10mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Trypentin AT 300mg/10mg Tablet

₹19.2/Tablet

Gabantip AT Tablet

Sun Pharmaceutical Industries Ltd

₹27.2/tablet

42% costlier

Laregab-AT Tablet

La Renon Healthcare Pvt Ltd

₹26.3/tablet

37% costlier

Tryptomer G 300mg/10mg Tablet

Dr Reddy's Laboratories Ltd

₹32.3/tablet

68% costlier

Amigaba 300 mg/10 mg Tablet

Icon Life Sciences

₹22.8/tablet

19% costlier

Trypwave-G Tablet

Brainwave Healthcare Pvt Ltd

₹17.6/tablet

8% cheaper

View all substitutes

Quick tips

Trypentin AT 300mg/10mg Tablet is used to treat certain types of long-lasting pain caused by damage to nerves.
Inform your doctor if you are taking any other pain-relieving medicines.
Along with taking this medicine, your doctor might advise you to undergo physiotherapy to get relief from pain.
Avoid taking antacids 2 hours before or after taking Trypentin AT 300mg/10mg Tablet as they make it harder for your body to absorb the medicine.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

Patient concerns

Most of the times when I get excited or have orgasm I feel pain in my testis and around it .

Dr. Pranay Gandhi

Sexology

hi PATIENT neuropathic pain mostly. take tablet emanzen d 1 bd

Sir Plz suggest me effective pain killer with minimum side effects for back pain and arthritis, which can be taken on regular basis as and when required.

Dr. Vikas Sharma

Neurology

dpeneds on the type of pain - muscular or neuropathic; show tro nearby neuro

I m suffering due to pain in left testis, so I visited pgimer Chandigarh in urology deptt. There I had gone for dopler ultrasound testis and its reports are normal Now whenever I lay down at bed I felt a smaal lump in testis,when I touchdown it, the pain radiates in whole left testis Now I m feeling pain sometimes in both tastis Is it a sign of early vericoseal Or something else Pls. Suggest

Dr. Pranay Gandhi

Sexology

it is a neuropathic pain and it won't show any abnormality in USG. i am worried about the lump u r talking about. its better if u consult a surgeon, PGIMER UROLOGY is the best place to go for examination. if they say its normal, its normal. for pain take pregaba m 1 od

FAQs

What is Trypentin AT 300mg/10mg Tablet?

Trypentin AT 300mg/10mg Tablet is a combination of two medicines: Gabapentin and Amitriptyline. This medicine is useful in the treatment of nerve pain (neuropathic pain). This medicine calms the damaged or overactive nerves by acting on the brain, thereby decreasing the pain sensation.

Can I stop taking Trypentin AT 300mg/10mg Tablet when my pain is relieved?

No, you should not stop taking Trypentin AT 300mg/10mg Tablet even if your pain is relieved. Continue to take it as advised by your doctor. If you stop taking Trypentin AT 300mg/10mg Tablet suddenly, you may experience withdrawal symptoms such as anxiety, sleeping difficulties, nausea, pain and sweating. You may need to gradually taper the dose before you stop the medication completely.

How to manage weight gain associated with the use of Trypentin AT 300mg/10mg Tablet?

The use of Trypentin AT 300mg/10mg Tablet can make you feel hungry which might make you eat more, thereby increasing your chances of putting on weight. However, preventing weight gain is easier than losing increased weight. Try to eat a healthy balanced diet without increasing your portion sizes (per-meal intake). Do not eat foods that contain a lot of calories, such as soft drinks, oily food, chips, cakes, biscuits and sweets. If you feel hungry between meals, avoid eating junk food and eat fruits, vegetables and low-calorie foods. Regular exercise will also help prevent weight gain. If you keep good eating habits and exercise regularly, you might not gain any weight.

Can the use of Trypentin AT 300mg/10mg Tablet cause sleepiness or drowsiness?

Yes, Trypentin AT 300mg/10mg Tablet may make you feel drowsy or you may suddenly fall asleep during your daily activities. Sometimes, you might not even feel drowsy or have any other warning signs before you suddenly fall asleep. Avoid driving a car, operating machinery, working at heights or participating in potentially dangerous activities until you know how the medicine affects you. Inform your doctor if you experience such episodes while taking this medicine.

Can the use of Trypentin AT 300mg/10mg Tablet affect my sex life?

The use of Trypentin AT 300mg/10mg Tablet can affect the sexual life of both men and women. Different sexual problems can occur due to Trypentin AT 300mg/10mg Tablet like decreased sexual desire, erectile dysfunction (inability to develop or maintain an erection during the sexual activity) and inability to reach orgasm. It can also cause a decrease in satisfaction and cause discomfort during intercourse. If you experience these problems, discuss with your doctor. Do not stop taking Trypentin AT 300mg/10mg Tablet.

Can the use of Trypentin AT 300mg/10mg Tablet change the color of urine?

Yes, Trypentin AT 300mg/10mg Tablet can the change the color of the urine to blue or green color. This change in color is expected while using Trypentin AT 300mg/10mg Tablet, and it is not harmful. Your urine color becomes normal once you stop taking Trypentin AT 300mg/10mg Tablet.

Are there any serious side effects associated with the use of Trypentin AT 300mg/10mg Tablet?

Serious side effects with Trypentin AT 300mg/10mg Tablet are uncommon and rare. Tell your doctor as soon as possible if you notice changes in body temperature, difficulty in breathing, increased heartbeat (palpitations), weakness, unsteadiness when walking, reduced coordination or slowed reactions, unusual changes in mood or behavior such as restlessness, nervousness or excitement, signs of depression, seeing or hearing things that are not there, irrational thinking, blurred or double vision, uncontrollable jerky eye movements, difficulty seeing, signs of frequent infections such as fever, severe chills, sore throat or mouth ulcers. These side effects are uncommon but may be serious and may need urgent medical attention.

How long will Trypentin AT 300mg/10mg Tablet take to act?

An initial benefit of Trypentin AT 300mg/10mg Tablet may be seen after 2 weeks of treatment. However, it may take around 2-3 months to see the full benefit. It may even take longer in some patients.

What if I forget to take Trypentin AT 300mg/10mg Tablet?

If you forget to take the scheduled dose of Trypentin AT 300mg/10mg Tablet and it is almost time for your next dose, skip the dose you missed and take your next dose at the scheduled time. Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally. Do not take a double dose to make up for the dose you missed because this may increase the risk of unwanted side effect. If you are not sure what to do, ask your doctor about taking Trypentin AT 300mg/10mg Tablet.

What if I take too much of Trypentin AT 300mg/10mg Tablet by mistake?

In a situation like this, contact your doctor immediately or seek emergency help at the nearest hospital. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Symptoms of an overdose may include drowsiness, weakness, unsteady when walking, having double visions, slurred speech or diarrhea, confusion, blurred vision, dizziness, body temperature changes (low and high), difficulty in breathing and increased heart beat.

Will a higher than the recommended dose of Trypentin AT 300mg/10mg Tablet be more effective?

No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having some serious side effects and toxicity. If you experience increased severity of your symptoms, that are not relieved by the recommended doses, please consult your doctor for re-evaluation.

Is there anything I need to avoid while taking Trypentin AT 300mg/10mg Tablet?

Trypentin AT 300mg/10mg Tablet may impair your thinking or reactions. Be careful while driving or doing an activity that requires you to be alert. Do not drink alcohol while taking Trypentin AT 300mg/10mg Tablet. It can increase the effects of alcohol, which could be dangerous. Grapefruit and grapefruit juice may also interact with this medicine and cause unwanted side effects. Avoid exposure to sunlight or tanning beds. Use of Trypentin AT 300mg/10mg Tablet can make you more prone to sunburns. Wear protective clothing and use sunscreen when you are outdoors during daytime.

How often should I see the doctor?

You may need to see your doctor regularly if you have started to take Trypentin AT 300mg/10mg Tablet. However, if the recommended dosage does not improve your symptoms or you experience some unwanted side effect that affects your routine activities, consult your doctor.

What are the instructions for the storage and disposal of Trypentin AT 300mg/10mg Tablet?

Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Amitriptyline. Princeton: Sandoz Inc; 2014. [Accessed 22 Apr. 2019] (online) Available from:
Gabapentin. Menlo Park: Depomed; 1993 [revised date]. [Accessed 22 Apr. 2019] (online) Available from:
Medscape. Amitriptyline. [Accessed 22 Apr. 2019] (online) Available from:
Gabapentin+Amitriptyline [Product Information]. Ahmedabad, Gujarat: La Renon Healthcare; 2020. [Accessed 16 Sep. 2024] (online) Available from:
La Renon. Gabapentin & Amitriptyline [product Information]. [Accessed 16 Sep. 2024] (online) Available from:

Marketer details

Name: Ariaan Pharma

Address: No. 22-50, Srinivasa Nagar, Simhachalam, Simhachalam, Visakhapatnam-530018, Andhra Pradesh, India

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.