Yondelis Injection
Prescription Required
Product introduction
Yondelis Injection is used in the treatment of some kinds of cancers. It is used in patients with advanced soft tissue sarcoma when previous medicines have been unsuccessful. It is also used with other medicines as part of combination therapy to treat ovarian cancer that has come back.
Yondelis Injection is given as an injection under the medical supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include headache, fatigue, vomiting, weakness and increased liver enzyme. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver and kidney. Generally, avoid alcohol consumption while on treatment.
Before taking it, tell your doctor if have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using.This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Yondelis Injection is given as an injection under the medical supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include headache, fatigue, vomiting, weakness and increased liver enzyme. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver and kidney. Generally, avoid alcohol consumption while on treatment.
Before taking it, tell your doctor if have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using.This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Yondelis Injection
Benefits of Yondelis Injection
In Soft tissue sarcoma
Soft tissue sarcoma is a type of sarcoma that develops in tissues such as bone and muscles. Yondelis Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. Follow your doctor’s instructions carefully and let your doctor know if any of the side effects bother you.
Side effects of Yondelis Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Yondelis
- Headache
- Fatigue
- Vomiting
- Weakness
- Nausea
- Increased liver enzymes
- Low blood platelets
- Increased creatine phosphokinase (CPK) level in blood
- Decreased white blood cell count (neutrophils)
- Decreased appetite
- Constipation
How to use Yondelis Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Yondelis Injection works
Trabectedin belongs to class of drugs called alkylating agents. It works by sticking to the DNA in cells and damaging it. This stops the cancer cells growing and multiplying.
.Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Yondelis Injection.
Pregnancy
CONSULT YOUR DOCTOR
Information regarding the use of Yondelis Injection during pregnancy is not available. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Yondelis Injection during breastfeeding is not available. Please consult your doctor.
Driving
UNSAFE
Yondelis Injection may cause side effects which could affect your ability to drive.
Yondelis Injection may make you feel tired and experience a loss of strength which may affect your ability to drive.
Yondelis Injection may make you feel tired and experience a loss of strength which may affect your ability to drive.
Kidney
CAUTION
Yondelis Injection should be used with caution in patients with kidney disease. Dose adjustment of Yondelis Injection may be needed. Please consult your doctor.
Liver
CAUTION
Yondelis Injection should be used with caution in patients with liver disease. Dose adjustment of Yondelis Injection may be needed. Please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- Yondelis Injection is given as an intravenous infusion (IV infusion) under the supervisión of a doctor.
- Do not skip any dose and complete the course as suggested by your doctor.
- Use an effective method of birth control to avoid pregnancy while taking this medication.
- Inform your doctor if you notice yellowing of eyes or skin, dark urine, muscle pain and skin rash.
- Your doctor may get regular blood tests done to monitor your blood cell count, platelet count and liver function.
Fact Box
Chemical Class
Benzazocine Derivative
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Anticancer-others
Interaction with drugs
Taking Yondelis with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Concurrent use may increase the risk of infections.
Do not use Trabectedin with Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted).
Concurrent use may increase the risk of infections.
Do not use Trabectedin with Purified Vi Polysaccharide Typhoid Vaccine.
Concurrent use may increase the risk of infections.
Do not use Trabectedin with Cholera Vaccine (Inactivated).
Ciclosporin may reduce blood levels of Trabectedin and its active form.
If concurrent use is essential, your doctor may monitor the effects of Trabectedin along with your overall
Clarithromycin may raise blood levels of Trabectedin.
Do not consume Trabectedin with Clarithromycin. If concurrent use is essential, watch out for symptoms such as nausea, vomiti
Patient concerns
User feedback
What are you using Yondelis Injection for?
Soft tissue s*
100%
*Soft tissue sarcoma
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1719-20.
- Trabectedin. Hertford, Herts: Immedica; 2007 [revised Jun. 2018]. [Accesed 27 Mar. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
Marketer details
Name: Janssen Pharmaceuticals
Address: Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060
Country of origin: India
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