Zebox 80mg Tablet is a medicine used to treat and prevent gout. Gout happens when there is too much uric acid in your body and it forms into crystals that can appear around your joints leading to painful and swollen joints. This medicine helps to keep uric acid levels low.

Zebox 80mg Tablet can be taken with or without food. You should keep taking it as recommended by your doctor even when you are not having a gout attack. If you stop, your symptoms may get worse because of the formation of more crystals in your joints. You can help yourself by making some changes to your diet (eg. avoiding alcohol and non-vegetarian foods) and drinking plenty of fluids.

Some of the common side effects of this medicine are liver function abnormalities, nausea, joint pain, and rashes. You may experience a temporary increase in the gout symptoms (rapid onset of severe pain, warmth, and redness in the joint) when you first start taking the medicine. However, do not stop taking the medicine. Your doctor may suggest some painkillers and additional medicines to help reduce or prevent these symptoms. Tell your doctor right away if you get any symptoms of liver disease like persistent nausea, dark urine, or yellowing of the eyes or skin.

Before taking this medicine, let your doctor know if you have any heart problems, stroke, thyroid problems, or kidney or liver problems. If you are pregnant or breastfeeding, this medicine is best avoided. Check with your doctor. You will need regular blood tests while taking this medicine to check that your liver is working properly.

Uses of Zebox Tablet

Treatment of Gout

Benefits of Zebox Tablet

In Treatment of Gout

Zebox 80mg Tablet is used to prevent and treat gout. Gout is caused by too much uric acid in your body. When the level becomes too high, crystals may form in and around certain joints and your kidneys. This can cause sudden and severe pain, redness, warmth, and swelling. This medicine works by preventing crystals from forming and reducing the levels of uric acid in your blood. This makes it less likely that you will suffer the symptoms and make them milder if you do have them. It is usually for long-term treatment and should be taken regularly until the dose is completed.

Side effects of Zebox Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Zebox

Nausea
Skin rash
Abnormal liver function
Joint pain
Rash

How to use Zebox Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zebox 80mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Zebox Tablet works

Zebox 80mg Tablet is a xanthine oxidase inhibitor. It works by decreasing blood uric acid, which is the chemical that causes gout.

Safety advice

Alcohol

CAUTION

Caution is advised when consuming alcohol with Zebox 80mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Zebox 80mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Zebox 80mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Zebox 80mg Tablet may cause side effects which could affect your ability to drive.
Zebox 80mg Tablet may cause dizziness, sleepiness, blurred vision, numbness or tingling sensation. This may affect your driving ability.

Kidney

CAUTION

Zebox 80mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Zebox 80mg Tablet may be needed. Please consult your doctor.
Limited information is available regarding the use of Zebox 80mg Tablet in these patients.

Liver

CAUTION

Zebox 80mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Zebox 80mg Tablet may be needed. Please consult your doctor.
Limited information is available regarding the use of Zebox 80mg Tablet in these patients.

What if you forget to take Zebox Tablet?

If you miss a dose of Zebox 80mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Zebox 80mg Tablet

₹12.6/Tablet

Febutax 80 Tablet

Leeford Healthcare Ltd

₹11.1/tablet

12% cheaper

Febuvel 80 Tablet

Leeford Healthcare Ltd

₹11.1/tablet

12% cheaper

Febutaz 80 Tablet

Sun Pharmaceutical Industries Ltd

₹25.8/tablet

105% costlier

Febuget 80 Tablet

Sun Pharmaceutical Industries Ltd

₹26.2/tablet

108% costlier

Febumac 80 Tablet

Macleods Pharmaceuticals Pvt Ltd

₹24/tablet

90% costlier

View all substitutes

Quick tips

Your doctor has prescribed Zebox 80mg Tablet to reduce episodes of gout attack.
Take it at the same time every day, with or without food.
Take plenty of fluids (2-3 litres) daily while on Zebox 80mg Tablet.
When you first start taking this medicine, you might have more gout attacks. Do not stop Zebox 80mg Tablet on having an acute attack of gout as that could make an attack worse.
Do not consume alcohol while taking this medicine as it may cause your gout to flare up.
Stop taking this medicine and inform your doctor straight away if you have symptoms like rash, itchiness, difficulties in breathing, fever, or swelling of limbs or face.

Fact Box

Chemical Class

Thiazole Derivative

Habit Forming

Therapeutic Class

PAIN ANALGESICS

Action Class

Xanthine oxidase Inhibitors-gout

Patient concerns

Pain and swelling in toe since a week now it turns reddish,ice and hot water therapy done with pain killer

Vipul Aggarwal

please get uric acid done probably gout attack as per ur history

Gout treatment after ayurvedic

Dr. Aanchal Maheshwari

Ayurveda

Take kaisor guggul 2 tab twice,. Anritarisht 20 ml twice after meal with water

Gout remedy and precautions

Dr. Ila Jain Khandelwal

Pathology

Hi For the exact treatment of gout you should consult a rheumatologist with all your reports. Precautions which you can follow are 1. eat low fat diet 2. Don't have foods with high purine content like shellfish, redmeat etc. 3. Slowly loose weight 4. Restrict your intake of alcohol 5. drink lots of water 6. Increase your intake of dairy products

FAQs

Q. What is Zebox 80mg Tablet used for?

Zebox 80mg Tablet is used to treat gout in adults. It is mainly used in patients who did not respond to the treatment with allopurinol or who are not able to take allopurinol. Gout is a type of arthritis in which uric acid, a naturally occurring substance in the body, builds up in the joints. It causes sudden attacks of redness, swelling, pain, and heat in one or more joints.

Q. What are the side effects of Zebox 80mg Tablet?

Zebox 80mg Tablet may cause common side effects such as abnormal liver test results, diarrhea, headache, rash, nausea, and even an increase in gout symptoms and localized swelling due to retention of fluids in tissues (edema). Whereas, the serious side effects of Zebox 80mg Tablet include heart problems, gout flares, liver problems, and severe skin and allergic reactions. Immediately inform your doctor if you experience any serious side effects.

Q. How long should I take Zebox 80mg Tablet?

The dose and duration of Zebox 80mg Tablet vary from person to person and are decided by your doctor. It may take several months before Zebox 80mg Tablet begins to prevent gout attacks. Do not stop taking Zebox 80mg Tablet without the advice of your doctor even if you feel better.

Q. What is the best time to take Zebox 80mg Tablet?

Zebox 80mg Tablet is advised to be taken once a day. It can be taken at any time of the day, but preferably at the same time each day so that you remember to take it every day. This will help maintain the levels of Zebox 80mg Tablet in the body. You can take this medicine with or without food.

Q. Can Zebox 80mg Tablet cause kidney damage?

Zebox 80mg Tablet may affect kidneys in different ways, though it is quite uncommon. You may experience blood in the urine, frequent urination, kidney stones, abnormal urine tests (increased level of proteins in the urine), and a reduction in the ability of the kidneys to function properly. Rarely, it may cause changes or decrease in urine amount due to inflammation in the kidneys (tubulointerstitial nephritis). Consult your doctor if your kidney functions get further affected.

Q. Can I stop taking Zebox 80mg Tablet on my own if I am fine and have no pain or swelling in joints?

No, do not stop taking Zebox 80mg Tablet without your doctor's advice even if you feel better. Discontinuation of medicine may increase the levels of uric acid. It may also worsen your symptoms due to the formation of new crystals of urate in and around your joints and kidneys.

Q. What are the things which I need to know while taking Zebox 80mg Tablet?

You should be aware that Zebox 80mg Tablet may cause serious heart problems which can be life-threatening in some cases. The symptoms of heart problems include chest pain, shortness of breath or trouble breathing, dizziness, fainting or feeling light-headed, rapid or irregular heartbeat. It may also cause numbness or weakness in one side of your body, slurring of speech and sudden blurry vision, or sudden severe headache. Immediately inform your doctor and seek medical help if you experience any of these symptoms.

Q. Can Zebox 80mg Tablet cause any liver problems?

Yes, Zebox 80mg Tablet use may cause liver problems. Your doctor may advise you to get regular blood tests done before and during treatment with Zebox 80mg Tablet to check how well your liver was working before and while taking this medicine. Inform your doctor if you notice symptoms such as fatigue, pain, or tenderness on the right side of the abdomen or loss of appetite for several days or longer. It may also cause changes in the color of urine (dark or tea-colored) and may make your skin or the white part of your eyes turn yellow (jaundice).

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Related lab tests

Creatinine

Creatinine - Spot

Uric Acid

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Grosser T, Smyth E, FitzGerald GA. Anti-Inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 997-98.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 534-35.
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Febuxostat. Wooburn Green, Buckinghamshire: A. Menarini Farmaceutica Internazionale SRL; 2008 [revised 29 Oct. 2018]. [Accessed 25 Jan. 2019] (online) Available from:
Febuxostat. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc.; 2009. [Accessed 02 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 02 Apr. 2019] (online) Available from:
Febuxostat [Prescribing Information]. [Last Reviewed: Dec 2018]. [Accessed 24 June 2023]. (online) Available from:

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