Zovorin 15mg Tablet is used to prevent the harmful effects of methotrexate (anticancer medicine). It is also used in the treatment of methotrexate overdose.

Zovorin 15mg Tablet can be taken with or without food. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects.

It is generally safe medicine to use with no common side effects if taken in the right amount. Your doctor may request regular blood tests to monitor your blood cells and serum methotrexate concentration in the blood.

Before taking it, tell your doctor if have seizures, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using, especially phenytoin for your seizures.

Uses of Zovorin Tablet

Prevention of Harmful effects of methotrexate

Benefits of Zovorin Tablet

In Prevention of Harmful effects of methotrexate

Zovorin 15mg Tablet helps protect the body cells against the harmful effects of methotrexate, an anti-cancer medicine. It is a form of vitamin B that is given after 24 hours of methotrexate administration. This makes sure that methotrexate has achieved its anti-cancer effects and also, Zovorin 15mg Tablet will prevent the other side effects such as anemia.

Side effects of Zovorin Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Zovorin

No common side effects seen

How to use Zovorin Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zovorin 15mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Zovorin Tablet works

Zovorin 15mg Tablet is a form of vitamin B. It works by protecting healthy cells from the toxic effects of methotrexate (anticancer medicine) while allowing it to enter and kill the cancer cells.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Zovorin 15mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Zovorin 15mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Zovorin 15mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving

SAFE

Zovorin 15mg Tablet does not usually affect your ability to drive.

Kidney

CONSULT YOUR DOCTOR

There is limited information available on the use of Zovorin 15mg Tablet in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Zovorin 15mg Tablet in patients with liver disease. Please consult your doctor.

What if you forget to take Zovorin Tablet?

If you miss a dose of Zovorin 15mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Zovorin 15mg Tablet

₹40.2/Tablet

Leucorin Tablet

Samarth Life Sciences Pvt Ltd

₹49.91/tablet

24% costlier

Unifolin 15mg Tablet

United Biotech Pvt Ltd

₹47/tablet

17% costlier

Neovorin 15mg Tablet

Neon Laboratories Ltd

₹19.2/tablet

52% cheaper

Leevarin 15 Tablet

Admac Pharma Ltd

₹49/tablet

22% costlier

Quick tips

You have been prescribed Zovorin 15mg Tablet to reduce the side effects of the medicine methotrexate.
Take it 24 hours after taking methotrexate. If taken at the same time, it may counteract the effect of methotrexate.
Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Zovorin 15mg Tablet may counteract the antiepileptic effects.

Fact Box

Chemical Class

Glutamic acid Derivatives

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Cytoprotective agents- methotrexate

Patient concerns

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Sexology

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FAQs

What is Zovorin 15mg Tablet used for?

Zovorin 15mg Tablet is used to prevent harmful effects of methotrexate (a cancer chemotherapy medication) when methotrexate is used to treat certain types of cancer. Zovorin 15mg Tablet is also used to treat people who have accidentally received an overdose of methotrexate or similar medications. It is also used for the treatment of megaloblastic anemia due to folic acid deficiency and when oral therapy is not feasible.

What is megaloblastic anemia?

Anemia is a blood disorder in which the number of red blood cells (RBCs) that carry oxygen is lower than usual. As a result, your tissues and organs don’t get enough oxygen. Megaloblastic anemia is a form of anemia characterized by very large red blood cells and a decrease in the number of those cells. Usually, megaloblastic anemia is due to vitamin B12 or folic acid deficiency.

How long does it take for Zovorin 15mg Tablet to work?

Zovorin 15mg Tablet starts acting on the body within 20-30 minutes of oral intake. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.

What are some of the laboratory tests conducted before or during the treatment with Zovorin 15mg Tablet?

Your doctor will prescribe blood tests to check your levels of serum methotrexate concentration (in case of methotrexate chemotherapy or overdose) to determine the optimal dose and duration of treatment with Zovorin 15mg Tablet. You will also be prescribed a complete blood count to monitor the number of red blood cells (in case of megaloblastic anemia). Along with this, your calcium levels will also be monitored in order to prevent hypercalcemia (excess calcium) since Zovorin 15mg Tablet contains calcium.

What measures should be taken to ensure the prompt excretion of methotrexate during treatment with Zovorin 15mg Tablet?

Maintenance of urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion. To monitor alkalinization of urine (this enhances drug excretion) so that the urinary pH is greater than 7.0 before methotrexate infusion. Foods, drinks, and drugs that may increase urinary acidity should be avoided during the therapy. Finally, blood methotrexate concentration should be measured at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Calcium Folinate. Hurley, Maidenhead: Hospira UK Limited; 1985 [revised Jan. 2018]. [Accessed 26 Mar. 2019] (online) Available from:
DailyMed. Leucovorin calcium. [Accessed 26 Mar. 2019] (online) Available from:

Marketer details

Name: Zuvius Life Sciences

Address: B-108/109/111, Kanara Business Centre, Near Everest Gardens, Laxmi Nagar, Ghatkopar East. Mumbai 400 075 Business Centre, Near Everest Gardens, Laxmi Nagar, Ghatkopar East. Mumbai 400 075

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.