Palbociclib

Information about Palbociclib

Palbociclib Uses

Palbociclib is used in the treatment of breast cancer. It is also used to treat patients with certain types of breast cancer (estrogen receptor-positive, human epidermal growth factor receptor 2-negative) which have spread to other organs. It is given together with hormonal anticancer therapies.

How Palbociclib works

Palbociclib is an anti-cancer medication. Cyclin dependent kinase 4 and 6 (chemical messengers) are downstream of signaling pathways which lead to the proliferation of cells. This medicine works by inhibiting cyclin dependent kinase 4 and 6, thus arrests the cancer cell cycle (cell growing process). It also targets the estrogen (hormone) receptor-positive breast cancer cells by disrupting the cell cycle.

Common side effects of Palbociclib

Fatigue, Hair loss, Rash, Vomiting, Diarrhea, Nausea, Decreased appetite, Infection, Stomatitis (Inflammation of the mouth), Anemia (low number of red blood cells), Weakness, Fever, Decreased white blood cell count
CONTENT DETAILS
Written By
Dr. Anuj Saini
MMST, MBBS
Reviewed By
Dr. Ashish Ranjan
MD (Pharmacology), MBBS
Last updated
09 Oct 2024 | 09:27 AM (UTC)

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Available Medicine for Palbociclib

PalbacePfizer Ltd
₹1 to ₹950005 variant(s)
PalbojasJasgur Life Sciences
₹72001 variant(s)
WebaceWembrace Biopharma Pvt. Ltd.
₹5397 to ₹59973 variant(s)
KixtaZydus Healthcare Limited
₹5985 to ₹71852 variant(s)
PiclibHetero Healthcare Limited
₹4700 to ₹76003 variant(s)
PalboproRPG Life Sciences Ltd
₹392001 variant(s)
PalborestMSN Laboratories
₹1400 to ₹54006 variant(s)
PalnatNatco Pharma Ltd
₹3500 to ₹45003 variant(s)
MyciclibKhandelwal Laboratories Pvt Ltd
₹5990 to ₹69903 variant(s)
PalbocibAprazer Healthcare Pvt Ltd
₹76001 variant(s)

Expert advice for Palbociclib

  • Take it with food, preferably at the same time every day. 
  • If you forget to take the medicine or vomit, skip the missed dose and follow a regular schedule. Do not take a double dose to make up missed dose
  • Use effective contraception method to prevent pregnancy while taking this medicine.
  • It may cause dizziness. Avoid driving or any activity requiring mental focus until you know how it affects you.
  • You may be asked for regular blood tests while taking this medication. Inform your doctor if you notice symptoms of infection like fever, chills, and weakness.
  • Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
  • Do not stop taking the medication without talking to your doctor first.

Frequently asked questions for Palbociclib

Palbociclib

Q. What kind of medicine is Palbociclib?

Palbociclib is an anti-cancer medicine. Palbociclib blocks proteins known as cyclin-dependent kinase inhibitors. Blocking these proteins can slow down the growth of cancer cells and delay the progression of the cancer.

Q. How long do I have to take Palbociclib?

The duration of treatment varies from person to person. Your doctor will decide the number of cycles you need to receive based on your condition, response to treatment and your tolerance to side effects. Your doctor may decrease your dose or stop your treatment temporarily or permanently if you experience certain side effects.

Q. Are the side effects of Palbociclib irreversible?

No, most of the side effects are reversible and disappear when the medicine is stopped. Neutropenia is a well-recognized adverse effect of Palbociclib in which the number of your white blood cells get reduced and your immune system gets weakened. As a result, you may be at greater risk of getting an infection while you are taking Palbociclib. However, this side effect disappears rapidly once you stop taking the medicine.

Q. Does treatment with Palbociclib require monitoring of blood counts?

Yes, blood tests are important since this medicine can lower your blood counts. The regular blood tests check the effect of Palbociclib on your blood cells (white blood cells, red blood cells, and platelets). These tests should be done at the beginning of each chemotherapy cycle, on the 15th day of the first 2 cycles, and as clinically indicated.

Q. How should I take Palbociclib?

Generally, Palbociclib is taken once daily for 21 consecutive days followed by 7 days off treatment to add up a complete cycle of 28 days. Take this medicine with food and at the same time each day. Swallow the whole capsules. Do not open, chew, or crush them. Do not take the capsules that are broken or cracked. If you vomit after taking Palbociclib, do not take another dose and continue your regular dosing schedule.

Q. Do I need to use birth control method while using Palbociclib?

Women of childbearing potential who are receiving Palbociclib and their partners should use adequate contraceptive methods (e.g. double-barrier contraception such as condom and diaphragm). These methods should be used during therapy and for at least 3 weeks after completing therapy for females. Men who are on Palbociclib therapy should use birth control methods for at least 14 weeks after completing the therapy.

Q. Does Palbociclib affect fertility?

Male fertility may be affected during treatment with Palbociclib. Thus, men may consider sperm preservation prior to beginning therapy with Palbociclib.

Q. What are the serious side effects of Palbociclib?

The serious side effects of Palbociclib include shortness of breath, dizziness, weakness, unusual bleeding or bruising or nosebleeds. It may also cause fever, chills or signs of infection and fast, irregular or pounding heartbeat. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment.

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