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Tirzepatide

Information about Tirzepatide

Tirzepatide Uses

Tirzepatide is used in the treatment of type 2 diabetes mellitus and obesity.

How Tirzepatide works

Tirzepatide mimics and enhances the activity of two naturally occurring hormones, GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), which regulate blood sugar, appetite, and energy balance. It increases insulin secretion in response to high blood sugar while reducing glucagon, a hormone that raises blood sugar levels, leading to improved glucose control.

Additionally, Tirzepatide slows the rate at which food leaves the stomach, prolonging the feeling of fullness and reducing the urge to eat more. It also acts on brain receptors to suppress appetite and promote satiety. This dual-receptor action makes Tirzepatide more effective in lowering blood sugar and supporting weight loss than single-hormone therapies.

Common side effects of Tirzepatide

Indigestion, Abdominal pain, Nausea, Diarrhea, Vomiting, Constipation

Available Medicine for Tirzepatide

MounjaroEli Lilly and Company India Pvt Ltd

₹3500 to ₹43752 variant(s)

Expert advice for Tirzepatide

Administer Tirzepatide on the same day each week to maintain consistent blood sugar control. Set a reminder to help you remember.
Use different areas of the abdomen, thigh, or upper arm to prevent skin irritation or lumps.
Monitor blood sugar levels regularly to check glucose levels, especially if using insulin or sulfonylureas, to prevent hypoglycemia.
Eat small, frequent, balanced meals, and avoid greasy, high-fat foods to reduce nausea.
Drink plenty of water to counteract potential dehydration from nausea, vomiting, or diarrhea.
Be watchful of symptoms like severe stomach pain, signs of pancreatitis (such as severe upper abdominal pain that may radiate to the back, along with nausea, vomiting, or fever) or allergic reactions, and consult a doctor immediately if they occur.
Tirzepatide may reduce the effectiveness of oral hormonal contraceptives. Switch to a non-oral contraceptive method or use an additional barrier method (e.g., condoms) for 4 weeks after starting this medicine and for 4 weeks after each dose escalation.
Let doctors know you're taking Tirzepatide before surgeries, as it may delay stomach emptying and increase aspiration risk.
While Tirzepatide can aid weight management, results take time, and maintaining a healthy lifestyle enhances its effectiveness.

Frequently asked questions for Tirzepatide

Tirzepatide

Q. What is Tirzepatide, and what is it used for?

Tirzepatide is a medication that contains tirzepatide and is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Additionally, it supports weight management by reducing appetite and promoting weight loss when combined with healthy lifestyle changes, such as balanced nutrition and regular physical activity.

Q. Is Tirzepatide an insulin?

No, Tirzepatide is not insulin. It is a GLP-1 and GIP receptor agonist that helps regulate blood sugar by increasing insulin secretion, reducing glucagon levels, and slowing digestion. Unlike insulin, Tirzepatide does not replace the body's insulin but enhances its natural response to food intake.

Q. How is Tirzepatide administered?

Tirzepatide is administered as a once-weekly subcutaneous injection in the abdomen, thigh, or upper arm. It should be injected on the same day each week, with or without food. The injection site should be rotated each time to prevent irritation. Use a new needle and syringe for each dose. Before use, ensure the solution is clear and colorless. Always follow your doctor’s instructions on dosage and administration.

Q. How does Tirzepatide help with weight loss?

Tirzepatide is administered as a once-weekly subcutaneous (under the skin) injection in the abdomen, thigh, or upper arm. It should be injected on the same day each week, with or without food. The injection site should be rotated each time to prevent irritation. Always use a new needle and syringe for each dose. Before use, ensure the solution is clear, colorless, and not frozen. Always follow your doctor’s instructions on dosage and administration.

Q. Can Tirzepatide cause hypoglycemia (low blood sugar)?

Yes, Tirzepatide can cause hypoglycemia (low blood sugar), especially if taken with insulin or other diabetes medications that lower blood sugar. Symptoms of hypoglycemia include dizziness, sweating, shakiness, and confusion. If it happens, eat or drink something sugary such as fruit juice, soda, hard candy, or a spoonful of honey immediately. Always monitor your blood sugar and talk to your doctor about adjusting medications if needed.

Q. Who should not use Tirzepatide?

Tirzepatide should not be used by individuals with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2) due to the risk of thyroid tumors. It is also contraindicated for those with severe allergic reactions to tirzepatide. Patients with a history of pancreatitis, severe gastrointestinal disease, or gastroparesis should avoid it, as it may worsen these conditions. Those with severe kidney or liver disease should use it cautiously under medical supervision.

Q. Can Tirzepatide be used during pregnancy?

Tirzepatide is not recommended during pregnancy due to a lack of sufficient safety data in pregnant women. Animal studies suggest potential risks to fetal development, but the effects in humans are unclear. Consult your doctor before using Tirzepatide if you are pregnant or planning to become pregnant.

Q. Do I have to take Tirzepatide for the rest of my life?

Tirzepatide is not a lifelong requirement for everyone, but its long-term use depends on your individual health needs. Some patients may eventually switch to a different medication or adjust their treatment based on their progress, lifestyle changes, or doctor’s recommendations. Always consult your doctor before discontinuing Tirzepatide.

Q. What happens when you stop taking Tirzepatide?

When you stop taking Tirzepatide, blood sugar levels may rise, and symptoms of type 2 diabetes, such as increased thirst, frequent urination, and fatigue, may return. If you were experiencing weight loss, you might also see gradual weight regain over time. Stopping Tirzepatide without an alternative diabetes management plan could increase the risk of complications like high blood sugar, cardiovascular issues, and worsening metabolic health.

Q. Can I save the leftover medicine for later use?

No, you should not save or reuse any leftover medicine. Tirzepatide comes in a single-use vial, which means it should be used immediately after opening. Once the vial is opened, the contents should not be stored or used again—even if some medicine is left. Using it in two parts is not safe and can lead to contamination, incorrect dosing, or reduced effectiveness. Consult your doctor if you have any concerns about your dosage or schedule.

Q. How can air bubbles be removed from Tirzepatide injection in a syringe?

Gently tap the syringe a few times so the air bubbles move to the top. Slowly push the plunger up until it reaches the 0.5 mL mark. By then, the syringe should be free of air bubbles. If a small air bubble sticks to the side of the syringe and doesn’t move when you tap it, don’t worry. It won’t affect your safety, the quality of the medicine, or how well it works.

Q. What is the storage instruction for Tirzepatide?

Store Tirzepatide in a refrigerator at 2°C to 8°C. If needed, it can be kept at room temperature (up to 30°C) for up to 21 days. If Tirzepatide is stored at room temperature, it should not be returned to the refrigerator. Discard if not used within 21 days after removing from the refrigerator. Do not freeze or use if frozen. Keep Tirzepatide in its original carton to protect from light.