Tolvaptan

Information about Tolvaptan

Tolvaptan Uses

Tolvaptan is used in the treatment of syndrome of inappropriate antidiuretic hormone secretion (SIADH) and low levels of sodium in the blood. It treats low levels of sodium in the blood, which can result from conditions such as heart failure, cirrhosis and syndrome of inappropriate antidiuretic hormone (SIADH).

How Tolvaptan works

Tolvaptan is a vasopressin antagonist. It works by blocking the effect of the hormone vasopressin in the body. This increases urine production, reduces the amount of water in the blood and raises the blood sodium level.

Common side effects of Tolvaptan

Dryness in mouth, Increased thirst, Dizziness, Nausea, Fatigue, Polyuria, Diarrhea
CONTENT DETAILS
Written By
Dr. Balshine Singh Kanwar
MD, MBBS
Reviewed By
Dr. Lalit Kanodia
MBA, MD Pharmacology
Written By
Dr. Betina Chandolia
MDS, BDS
Reviewed By
Dr. Lalit Kanodia
MBA, MD Pharmacology
Last updated
08 Nov 2024 | 06:37 AM (UTC)

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Available Medicine for Tolvaptan

NatriseSun Pharmaceutical Industries Ltd
₹587 to ₹11002 variant(s)
ResodimLupin Ltd
₹803 to ₹12732 variant(s)
Hyponat-OZydus Cadila
₹7471 variant(s)
TolvatMSN Laboratories
₹616 to ₹11812 variant(s)
TolvascaGlenmark Pharmaceuticals Ltd
₹824 to ₹11502 variant(s)
TvaptanCentaur Pharmaceuticals Pvt Ltd
₹602 to ₹11013 variant(s)
TolsamaMSN Laboratories
₹685 to ₹8252 variant(s)
TolvamacMacleods Pharmaceuticals Pvt Ltd
₹634 to ₹7562 variant(s)
ShiokemAlkem Laboratories Ltd
₹440 to ₹8002 variant(s)
VaptanSteadfast Medishield Pvt Ltd
₹700 to ₹10002 variant(s)

Expert advice for Tolvaptan

  • Tolvaptan treats low sodium levels in the blood.
  • It also improves urine flow without causing the body to lose too much sodium as you urinate.
  • Take it at the same time everyday. Take it according to the dose and duration prescribed by your doctor.
  • To avoid dehydration, it is best to drink something as soon as you feel thirsty, but avoid alcoholic drinks.
  • Do not take Tolvaptan if you are unable to urinate, if you are unable to tell when you are thirsty, or if you are severely dehydrated.
  • You will need to be in a hospital under observation any time you start or restart treatment with Tolvaptan.
  • Inform your doctor if you notice problems with speech or muscle control, trouble swallowing, trouble moving your arms and legs, or mood changes.
  • Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.

Frequently asked questions for Tolvaptan

Tolvaptan

Q. What is the most important information I need to be aware of while taking Tolvaptan?

Tolvaptan may cause the level of sodium in your blood to increase too quickly. This quick increase in sodium levels [osmotic demyelination syndrome (ODS)] may cause serious nerve damage, which can further cause coma and even death. The symptoms of ODS could be trouble in speaking, trouble in swallowing or a feeling of food or liquid getting stuck while swallowing, drowsiness, confusion, mood changes, fits, trouble controlling body movement (involuntary movement) and weakness in muscles of the arms and legs.

Q. For how long do I need to take Tolvaptan?

Tolvaptan is used for correction of sodium levels in blood. Though the dose and duration are prescribed by the doctor, Tolvaptan should not be taken for more than 30 days. Once the sodium levels return to normal, it can be stopped after talking to the doctor.

Q. Does Tolvaptan affect the sugar levels in blood?

Yes, Tolvaptan may increase the blood sugar levels. Therefore, patients with diabetes mellitus need to be extra careful while taking Tolvaptan and should keep a check on blood sugar levels regularly.

Q. Who should not take Tolvaptan?

You should not take Tolvaptan if you have low sodium levels, cannot replace fluids by drinking or if you cannot tell when you are thirsty, dizzy or feeling faint or if your kidneys are not working properly because of excessive loss of fluids. You should also avoid Tolvaptan if your body is not able to make urine, you are allergic to Tolvaptan or if you are on certain medicines which interfere with the working of Tolvaptan.

Q. Can I have grapefruit juice while taking Tolvaptan?

No, you should not take grapefruit or grapefruit juice while on Tolvaptan. The reason being, grapefruit or grapefruit juice may increase the levels of Tolvaptan in your blood and your sodium levels may rise too quickly.

Q. What will happen if I take excess of Tolvaptan?

You may need urgent medical attention. Call your doctor or seek emergency service at a nearby hospital. Symptoms of taking too much Tolvaptan may include thirst, dry and flaky skin, sunken eyes, rapid heartbeat, rapid and shallow breathing, very low blood pressure, passing more urine than normal and fainting.

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