
BRCA1 and BRCA2 Gene Sequencing Panel



The BRCA1 and BRCA2 Gene Sequencing Panel is a blood test that checks for inherited mutations in the BRCA1 and BRCA2 genes. These genes normally help repair DNA and prevent uncontrolled cell growth. Detecting mutations helps doctors understand your risk for breast, ovarian, prostate, and pancreatic cancers; guide preventive measures; and support personalized treatment planning.








Understanding BRCA1 and BRCA2 Gene Sequencing Panel
The BRCA1 and BRCA2 Gene Sequencing Panel is a comprehensive genetic test designed to evaluate the BRCA1 and BRCA2 genes, which are tumor suppressor genes critical for DNA repair and preventing cells from becoming cancerous. Mutations in these genes can disrupt normal cell growth and increase the risk of several cancers, most commonly breast and ovarian cancer, but also prostate and pancreatic cancers.
By sequencing these genes, the panel identifies small mutations as well as large deletions or duplications that may predispose individuals to cancer. For individuals over 18 years old who carry these mutations, early detection allows for preventive strategies such as increased monitoring, risk-reducing surgeries, lifestyle modifications, or other medical interventions.
Doctors may recommend the BRCA1 and BRCA2 Gene Sequencing Panel for individuals who have a strong family history of breast or ovarian cancer, a personal history of these cancers at a young age, or if family members are known carriers of BRCA mutations. Genetic counseling is recommended for all individuals undergoing testing to help understand the results and discuss preventive or therapeutic strategies.
For this test, it is important to provide the histopathological report of the patient (in primary cases), relevant family history (for first-degree relative screening), clinical history, other test reports, and a doctor’s prescription at the time of sample collection. The Tata 1mg consolidated Test Requisition Form (TRF) must be filled and submitted along with the sample. Consent forms are required for minors to ensure proper authorization for testing.
Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for a proper understanding of the test results.
Note: Genetic counseling can be provided. If interested, please send the request to this email id: [email protected]
What does BRCA1 and BRCA2 Gene Sequencing Panel measure?
The BRCA1 and BRCA2 Gene Sequencing Panel detects mutations in the BRCA1 and BRCA2 genes, which are tumor suppressor genes responsible for repairing DNA and preventing uncontrolled cell growth. The test identifies both small genetic changes (like point mutations) and larger deletions or duplications in these genes. Detecting such mutations helps assess an individual’s inherited risk for breast, ovarian, prostate, and pancreatic cancers. By understanding whether these genetic alterations are present, doctors can guide preventive strategies, inform treatment decisions in affected individuals, and provide genetic counseling for family members at risk.





FAQs related to BRCA1 and BRCA2 Gene Sequencing Panel
- Petrucelli N, Daly MB, Pal T. BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer. 1998 Sep 4 [Updated 2025 Mar 20]. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2025. Available from:
- Casaubon JT, Kashyap S, Regan JP. BRCA1 and BRCA2 Mutations. [Updated 2023 Jul 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from:
- BRCA Gene Changes: Cancer Risk and Genetic Testing [Internet]. American Cancer Society: 19 Jul. 2024 [Accessed 21 Oct. 2025]. Available from:
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