Angiotensin Converting Enzyme

Angiotensin-converting enzyme (ACE) is an enzyme produced primarily by the liver and kidneys and a few other organs helps maintain the renin-angiotensin system (RAAS) which is important for regulating blood pressure and fluid balance. ACE helps in converting inactive angiotensin I enzyme to active angiotensin II enzyme (a potent vasoconstrictor).

The Angiotensin Converting Enzyme test is recommended when there is suspicion of sarcoidosis, a condition characterized by the growth of a tiny collection of inflammatory cells in various organs, most commonly the lungs and lymph nodes. It also helps monitor treatment response in individuals diagnosed with sarcoidosis. In certain cases, the Angiotensin Converting Enzyme test can help in differentiating between sarcoidosis and other conditions with similar symptoms, such as tuberculosis or lymphoma. 

The Angiotensin Converting Enzyme test is not intended to be used as a standalone test and should be used in conjunction with other diagnostic methods for accurate diagnosis and disease monitoring. Additionally, ACE levels can vary based on factors such as age, genetic background etc., and these can potentially affect the test results. Therefore, the results should be interpreted in conjunction with other clinical findings and relevant diagnostic tests. 

Elevated levels of ACE are found in individuals with active sarcoidosis, although moderately increased levels are seen in a variety of diseases and disorders, such as HIV, histoplasmosis, diabetes mellitus, hyperthyroidism, lymphoma, alcoholic cirrhosis, Gaucher disease, tuberculosis, leprosy etc. Decreased ACE levels are seen in people with chronic obstructive pulmonary disease (COPD), lung diseases such as emphysema, lung cancer, cystic fibrosis etc., starvation, steroid drug therapy, hypothyroidism.

Generally, overnight fasting is preferred but not mandatory for this test. Inform your doctor about all the medications or supplements that you may be taking as these can potentially affect the test results. 

Lab test results may vary across laboratories. Do not self-medicate at home solely based on these test results and always consult your doctor for proper understanding of the test results. The insights from the Angiotensin Converting Enzyme test will help doctors prescribe targeted treatments.