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Anti Cardiolipin IgM Antibody

Also known as Cardiolipin Antibody IgM
899
You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. No special preparation is required.

Understanding Anti Cardiolipin IgM Antibody


What is Anti Cardiolipin IgM Antibody?

The Anti Cardiolipin IgM Antibody is a blood test that helps to detect the presence of immunoglobulin M (IgM) antibodies that target cardiolipins (a phospholipid that is part of the cell membrane). These antibodies are commonly associated with autoimmune disorders, particularly Antiphospholipid Syndrome (APS), which can lead to an increased risk of blood clots, recurrent miscarriages, and other complications.

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by antiphospholipid antibodies in the blood. These antibodies target phospholipid molecules, such as cardiolipin, leading to an increased risk of pregnancy complications and thrombotic events, such as deep vein thrombosis (DVT), pulmonary embolism (PE), stroke, and myocardial infarction. The Anti Cardiolipin IgM Antibody helps detect the presence of anticardiolipin immunoglobulin M (IgM) antibodies (a form of antiphospholipid antibodies) and helps diagnose and manage APS.

The test is typically recommended for individuals with a history of unexplained blood clots, recurrent miscarriages, or those with symptoms suggestive of antiphospholipid syndrome. Furthermore, the Anti Cardiolipin IgM Antibody test is valuable for monitoring the effectiveness of treatment and managing autoimmune diseases, such as APS and systemic lupus erythematosus (SLE), where anticardiolipin antibodies can be present.

A positive test result does not always indicate the presence of antiphospholipid syndrome, as these antibodies can be found in other conditions, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, as well as in some healthy people. Hence, the Anti Cardiolipin IgM Antibody test results should be interpreted in conjunction with other tests and clinical findings to confirm a diagnosis.

Anti-cardiolipin antibody levels can fluctuate, and a single test may not provide a definitive diagnosis. Hence, the Anti Cardiolipin IgM Antibody test is usually repeated several weeks later to determine whether the antibody is temporary or persistent, allowing the doctors to facilitate a tailored care approach for individuals with blood clotting disorders and autoimmune conditions. 

No special preparation is needed before the Anti Cardiolipin IgM Antibody test. However, you should inform your doctor about any medications or supplements you take, as certain medications may affect the test results. 

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation; therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for a proper understanding of the test results. The insights from this test help the doctor tailor an appropriate treatment plan.

What is Anti Cardiolipin IgM Antibody used for?

The Anti Cardiolipin IgM Antibody test is done: 

  • To diagnose autoimmune disorders like antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE).
  • When you have symptoms consistent with an autoimmune disorder. 
  • To identify the cause of unexplained blood clots (thrombotic episodes), recurrent miscarriages in women, especially in the second and third trimesters of pregnancy, premature labor, or pre-eclampsia.
  • To monitor treatment response for autoimmune disorders.

What does Anti Cardiolipin IgM Antibody measure?

The Anti Cardiolipin IgM Antibody test detects specific immunoglobulins IgM antibodies against cardiolipin, a phospholipid found in cell membranes. These antibodies can indicate autoimmune disorders such as antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE).

IgM antibodies are typically the first antibodies produced by the immune system in response to an infection or antigen, and the presence of IgM antibodies in the blood sample may suggest recent or acute immune system activation. Thus, the Anti Cardiolipin IgM Antibody test is often used to diagnose acute conditions or recent immune responses, such as recent blood clot formation in disorders like antiphospholipid syndrome (APS).

Interpreting Anti Cardiolipin IgM Antibody results


Interpretations

 

RESULT IN GPL

REMARKS

< 15

Negative

15 - 20

Equivocal

20 - 80

Low positive

> 80

High positive

 

 

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Anti Cardiolipin IgM Antibody


Frequently Asked Questions about Anti Cardiolipin IgM Antibody

Q. What is the Anti Cardiolipin IgM Antibody test?

The Anti Cardiolipin IgM Antibody test is a blood test that detects the presence of immunoglobulin M (IgM) antibodies directed against cardiolipin, a phospholipid found in cell membranes. These antibodies may indicate an increased risk of thrombotic events and certain autoimmune disorders, particularly antiphospholipid syndrome (APS).

Q. Why is the Anti Cardiolipin IgM Antibody test performed?

The test is performed to assess the risk of thrombotic events, such as deep vein thrombosis (DVT), pulmonary embolism (PE), stroke, and myocardial infarction, in individuals suspected of having APS or other autoimmune disorders associated with antiphospholipid antibodies. It is also used in the evaluation of recurrent miscarriages and pregnancy complications.

Q. When should I get the Anti Cardiolipin IgM Antibody test?

You can get the Anti Cardiolipin IgM Antibody test if you have symptoms of an autoimmune disorder, such as unexplained blood clots, recurrent miscarriages, or prolonged PTT (which means that clotting is taking longer to occur than normal). It may also be done if you have been diagnosed with lupus to monitor your condition.

Q. Does the Anti Cardiolipin IgM Antibody test pose any risk?

No, the Anti Cardiolipin IgM Antibody test is generally safe with minimal risks. You may feel slight discomfort during blood sample collection, but the chances of serious complications are scarce.

Q. How often should I be tested?

The testing frequency depends on your symptoms, medical history, and the doctor's discretion. If you have a known autoimmune condition, your doctor may suggest regular testing to monitor your condition.

Q. What does positive IgM cardiolipin mean?

A positive result for cardiolipin IgM antibodies means that cardiolipin IgM antibodies are present in the blood. This can be due to several health conditions, like Antiphospholipid syndrome (APS), Systemic lupus erythematosus (SLE), deep vein thrombosis, recurrent miscarriages, etc.

Q. What are the symptoms of antiphospholipid syndrome (APS)?

Common symptoms of APS are blood clots in the legs, discoloration, tenderness, swelling of the legs, repeated miscarriages or stillbirths, chest pain, low platelets, discomfort in the arms, back, or neck, irregular heartbeat, etc.

Q. Is there a cure for antiphospholipid syndrome?

There is no such cure for antiphospholipid syndrome yet. However, timely and proper treatment can significantly reduce the risk of excessive and irregular blood clotting. Furthermore, an anticoagulant medicine per the doctor’s prescription can help you manage the symptoms.

Q. What other tests might I have along with Anti Cardiolipin IgM Antibody test?

The additional tests may vary at your doctor’s discretion. However, commonly prescribed tests include a complete blood cell count, partial thromboplastin time and activated prothromboplastin time, antinuclear antibody test, and antiphospholipid antibody test.

Q. If I have anticardiolipin antibodies, will I develop blood clots?

Not necessarily. The cardiolipin antibodies represent a risk factor, but they cannot predict whether a person will have recurrent blood clots or other associated complications. If a person does have blood clots, the presence of the antibodies cannot predict their frequency or severity either. Compared to lupus anticoagulants, cardiolipin antibodies are a lesser risk factor for thrombosis.

Q. Should I tell a new doctor that I have anticardiolipin antibodies?

Yes, this is an essential part of your medical history. Your doctor needs this information, even if you are asymptomatic, so that they can tailor any procedures or medical treatment plans around this risk factor.
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Anti Cardiolipin IgM Antibody test price for other cities


Price inNew DelhiRs. 899
Price inBangaloreRs. 849
Price inMumbaiRs. 919
Price inNavi MumbaiRs. 919
Price inHyderabadRs. 849
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References

  1. Overview-Antiphospholipid syndrome (APS) [Internet]. NHS; 20 Jun. 2022 [Accessed 05 Jun. 2024]. Available from: https://www.nhs.uk/conditions/antiphospholipid-syndrome/treatment/#:~:text=If%20you're%20diagnosed%20with,plenty%20of%20fruit%20and%20vegetables External Link
  2. Cardiolipin Antibody [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 05 Jun. 2024]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=cardiolipin_antibody External Link
  3. Reddel SW, Krilis SA. Testing for and clinical significance of anticardiolipin antibodies. Clin Diagn Lab Immunol. 1999 Nov;6(6):775-82. [Accessed 05 Jun. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC95774/ External Link
  4. Wang D, Lv W, Zhang S, Zhang J. Advances in the Research on Anticardiolipin Antibody. J Immunol Res. 2019 Dec 1;2019:8380214. [Accessed 05 Jun. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914984/ External Link
  5. Favaloro EJ, Mohammed S, Vong R, Pasalic L. Antiphospholipid Antibody Testing for Anti-cardiolipin and Anti-β2 Glycoprotein I Antibodies Using Chemiluminescence-Based Panels. Methods Mol Biol. 2023;2663:297-314. [Accessed 05 Jun. 2024]. Available from: https://pubmed.ncbi.nlm.nih.gov/37204719/ External Link
  6. Ortel TL. Antiphospholipid syndrome: laboratory testing and diagnostic strategies. Am J Hematol. 2012 May;87 Suppl 1(Suppl 1):S75-81. [Accessed 05 Jun. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848066/ External Link
  7. Bustamante JG, Goyal A, Singhal M. Antiphospholipid Syndrome. [Updated 2023 Feb 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430980/ External Link
  8. BLOOD CLOTTING DISORDERS [Internet]. NIH; 24 Mar. 2022. [Accessed 05 Jun. 2024]. Available from: [Accessed 05 Jun. 2024]. Available from: https://www.nhlbi.nih.gov/health/antiphospholipid-syndrome External Link

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