Anti - dsDNA Antibody (Double Stranded, Native) in Dilutions by IFA

The Anti - dsDNA Antibody (Double Stranded, Native) in Dilutions by IFA is a blood test that helps detect and give semi-quantitative titres for the presence of antibodies specific to double-stranded DNA. anti-ds DNA antibodies are indicative of certain autoimmune disorders, particularly systemic lupus erythematosus (SLE). The test uses the Immunofluorescence Assay (IFA) method to detect anti-native DNA antibody, also known as anti-double-stranded DNA antibody. This is a kind of anti-nuclear antibody (ANA) that targets the double-stranded DNA in the body.

This test is performed when an individual exhibits symptoms suggestive of SLE such as joint pain and stiffness, skin rashes, butterfly-shaped rash on the face, kidney dysfunction, unexplained fever, etc. It helps in monitoring disease activity and progression in patients already diagnosed with SLE. Additionally, this test helps differentiate SLE from other autoimmune diseases like rheumatoid arthritis, etc. The insights from the Anti - dsDNA Antibody (Double Stranded, Native) in Dilutions by IFA test enable timely initiation of treatments, crucial for managing symptoms and preventing complications associated with SLE. High-titers of nDNA may be highly suggestive of SLE, but it should be correlated with the overall clinical history of a patient. Low titers of nDNA antibodies are often present in the sera of patients with rheumatoid arthritis, Sjögren’s syndrome, progressive systemic sclerosis, dermatomyositis, discoid lupus erythematosus, and mixed connective tissue disease.