
SSB - LA (Soluble Substance B) - IgG antibody









The SSB - LA (Soluble Substance B) - IgG antibody test detects SS-B (La) antibodies in the blood. These antibodies are key markers for autoimmune diseases such as Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE). This test supports the diagnosis and differentiation between different autoimmune disorders.













Understanding SSB - LA (Soluble Substance B) - IgG antibody
The SSB - LA (Soluble Substance B) - IgG antibody test is a blood test used to identify autoantibodies against the SS-B (La) antigen, a protein found inside cells. SS-B antibodies are commonly associated with Sjögren’s syndrome and are also seen in systemic lupus erythematosus (SLE) and other connective tissue diseases.
Doctors recommend the SSB - LA (Soluble Substance B) - IgG antibody test when symptoms like chronic dry eyes, dry mouth, joint pain, fatigue, or skin rashes suggest an autoimmune condition. Anti SS-B antibodies are often tested along with anti-SSA antibodies, as both can appear together in similar disorders.
The SSB - LA (Soluble Substance B) - IgG antibody test is particularly important for supporting a suspected diagnosis of Sjögren’s syndrome or lupus, differentiating between overlapping autoimmune conditions, and assessing risks in pregnant women with autoimmune diseases, as certain antibodies can affect the newborn. Early detection plays a key role in planning the right treatment and monitoring disease progression effectively.
No special preparation is required for the SSB - LA (Soluble Substance B) - IgG antibody test. Inform the doctor about all the medications and supplements currently being taken, as some of them may affect the test results. Your doctor may advise changes if needed before the test.
Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate and always consult a doctor to understand the test results correctly.
Please note: This is an outsourced test. The sample is collected by TATA 1MG and processed at a NABL accredited partnered lab.
What does SSB - LA (Soluble Substance B) - IgG antibody measure?
The SSB - LA (Soluble Substance B) - IgG antibody is a blood test that detects IgG autoantibodies that react against the SS-B (La) antigen. A positive result indicates an autoimmune response and helps support the diagnosis of disorders such as lupus or Sjögren’s syndrome.





FAQs related to SSB - LA (Soluble Substance B) - IgG antibody
- Rao L, Liu G, Li C, Li Y, Wang Z, Zhou Z, Tong S, Wu X. Specificity of anti-SSB as a diagnostic marker for the classification of systemic lupus erythematosus. Exp Ther Med. 2013 Jun;5(6):1710-1714. [Accessed 19 Aug. 2025]. Available from:
- Cioni P, Chretien P, Goulvestre C, Ballot E, Khelifi-Touhami D, Mariette X, Nocturne G. Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value. RMD Open. 2025 Feb 4;11(1):e005212. [Accessed 19 Aug. 2025]. Available from:
- The SSB-positive/SSA-negative antibody profile is not associated with key phenotypic features of Sjögren’s syndrome [Internet]. ScienceDirect; [Accessed 19 Aug. 2025]. Available from:
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