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BCR-ABL Kinase Domain Mutations near me in Bhubaneshwar
Also known as Imatinib Resistance Mutation Analysis Test
You need to provide
Blood
This test is for
Male, Female
Understanding BCR-ABL Kinase Domain Mutations in Bhubaneshwar
What is BCR-ABL Kinase Domain Mutations in Bhubaneshwar?
Chronic Myelogenous leukemia (CML) is characterized by the presence of the Philadelphia chromosome, the product of the t(9;22)(q34;q11) translocation. This translocation results in the BCR/ABL fusion protein with constitutive ABL tyrosine kinase activity. The kinase inhibitor imatinib inhibits ABL kinase activity and is now the standard of care for early-phase CML.
Prolonged treatment with Imatinib can lead to drug resistance, especially in patients with advanced disease. This test detects greater than 90 percent of ABL mutations that may lead to Imatinib resistance, including the important T315I and P-loop mutations.
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