CENP-B
Understanding CENP-B
What is CENP-B?
CENP-B protein is essential for the cell division process in the body. The CENP-B test helps to check the presence of CENP-B protein in the collected sample of cells. This test can help to study how this protein behaves in different types of cells, especially cancer cells. This test helps to detect autoimmune diseases such as systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome, and primary biliary cirrhosis. You may get this test done if you have symptoms like hardening of the skin, tightening of muscles in fingers and toes, digestive problems, shortness of breath, inflammation, joint pain, and sometimes irregular heartbeat.
What does CENP-B measure?
The CENP-B, also known as Centromere Protein B test is used to detect antibodies against the centromere protein CENP-B in the blood. This protein plays a role in cell division and is associated with certain autoimmune disorders. The test is primarily used to diagnose Systemic Sclerosis (SSc), including its specific form known as CREST syndrome (Limited Systemic Sclerosis). A positive result suggests the presence of these antibodies, helping doctors confirm a diagnosis of scleroderma or CREST syndrome. A negative result means that these antibodies are not found, making these conditions less likely, but it doesn't completely rule them out. In some cases, further testing may be needed to confirm the diagnosis.
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