
Herpes Simplex Virus 2, IgG









The Herpes Simplex Virus 2, IgG test is performed to determine previous exposure to herpes simplex virus 2 which causes genital herpes infection. This test detects the presence of IgG antibodies that are produced in response to a past or prolonged infection. Getting tested helps manage herpes infection and prevent it from spreading further.













Understanding Herpes Simplex Virus 2, IgG
Herpes simplex virus-2 (HSV-2), is primarily transmitted through sexual contact, leading to painful sores and blisters in the genital area. Most people who have HSV-2 are unaware they are infected because signs and symptoms may be mild and go unnoticed. While herpes is not curable, it can be well managed with medicines.
In those who experience symptoms, it may include painful, recurring blisters or ulcers, painful urination, unusual discharge from the urethra and vagina, fever, body aches, sore throat, and swollen lymph nodes. Once an individual gets infected and the initial infection resolves, the virus remains inside the body in a latent form for the rest of its life. During periods of stress or illness, the virus may reactivate leading to recurrent outbreaks.
The Herpes Simplex Virus 2, IgG test is crucial for diagnosing HSV-2 infections, especially in individuals who have had sexual contact with an infected partner. The test can help determine if a person has been previously exposed to the virus and developed antibodies. Doctors may also recommend HSV-2 IgG testing to expectant mothers to help determine evidence of prior herpes infection. This test can be done at any time without any prior specific preparation.
Talk to your doctor about your specific test results. Narrate your complete medical history and symptoms to help them correlate your clinical and laboratory findings and formulate your treatment plan. Negative results may not exclude an eventual infection, in case of equivocal results, a repeat test is recommended after 8-14 days.
What does Herpes Simplex Virus 2, IgG measure?
The Herpes Simplex Virus 2, IgG test looks for the presence of IgG antibodies against HSV-2 in response to the Herpes infection. IgG antibodies are the most frequent type of antibody, which are developed around 18 to 21 days after the virus invades the body and remains in the body for life. Thus, the presence of IgG antibodies typically means an individual has been infected with the HSV-2 at some point. Detection of HSV-2 infection allows doctors to provide necessary support and guidance to individuals suffering from genital herpes, leading to better treatment outcomes and improved quality of life.





FAQs related to Herpes Simplex Virus 2, IgG
- Genital Herpes – CDC Basic Fact Sheet [Internet]. CDC; 03 Jan. 2022 [Accessed 30 Jan. 2024]. Available From:
- Genital Herpes Screening FAQ [Internet]. CDC; 11 Jul. 2022 [Accessed 30 Jan. 2024]. Available from:
- Herpes simplex virus [Internet]. WHO; 05 Apr. 2023 [Accessed 30 Jan. 2024]. Available from:
- Tada DG, Khandelwal N. Serum HSV-1 and 2 IgM in Sexually Transmitted Diseases - More for Screening Less for Diagnosis: An Evaluation of Clinical Manifestation. J Glob Infect Dis. 2012 Jul;4(3):S1-4. [Accessed 30 Jan. 2024]. Available from:
- Nath P, Kabir MA, Doust SK, Ray A. Diagnosis of Herpes Simplex Virus: Laboratory and Point-of-Care Techniques. Infect Dis Rep. 2021 Jun 2;13(2):518-539. [Accessed 30 Jan. 2024]. Available from:
- Sauerbrei A. Herpes Genitalis: Diagnosis, Treatment and Prevention. Geburtshilfe Frauenheilkd. 2016 Dec;76(12):1310-1317. [Accessed 30 Jan. 2024]. Available from:
- Katz D, Hilliard JK, Mirkovic RR, Word RA. ELISA for detection of IgG and IgM antibodies to HSV-1 and HSV-2 in human sera. J Virol Methods. 1986 Aug;14(1):43-55. [Accessed 30 Jan. 2024]. Available from:
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