Hepatitis C Antibody (HCV), Rapid Screening Test
Understanding Hepatitis C Antibody (HCV), Rapid Screening Test
What is Hepatitis C Antibody (HCV), Rapid Screening Test?
The Hepatitis C Antibody (HCV), Rapid Screening Test is a rapid card based test which detects the presence of antibodies against the hepatitis C virus (HCV) in blood. It is indicated for initial screening of HCV and as an aid in diagnosis of individuals with symptoms of HCV infection or those at high risk.
Hepatitis C is a viral infection caused by the hepatitis C virus (HCV) that affects your liver. The common symptoms of a recent HCV infection include fever, fatigue, nausea, vomiting, decreased appetite, abdominal pain, dark urine, light-colored stools, joint pain, and jaundice (yellowing of skin and the whites of the eyes). This infection spreads when you come into contact with an infected person's blood, or body fluids. It can also spread through sexual contact, sharing needles, syringes, or any drug-injection equipment, transfusion of infected blood, or from a mother to the child during birth.
The World Health Organization (WHO) recommends an HCV Antibody test for people who are at an increased risk of this infection, have come in contact with an already infected person, or show any of the symptoms of an HCV infection. However, about 80% of the infected individuals do not exhibit any symptoms after the initial infection.
The Hepatitis C Antibody (HCV), Rapid Screening Test test is only an initial screening test for detecting HCV antibodies. If this test is positive, more specific tests like HCV RNA, should be performed to confirm HCV infection. The Centre for Disease Control (CDC) recommends using these supplemental tests (like HCV RNA) to distinguish between true and false positives. If both the initial test and the confirmatory test are positive, it indicates an active HCV infection. A negative result generally means there is no infection, but it does not preclude the possibility of HCV infection especially in individuals with weak immune systems. Early diagnosis can prevent health problems resulting from the infection and further virus transmission. The test also helps distinguish HCV infection from other forms of hepatitis.
Usually, no special preparation is needed for this test. You may eat and drink as per your daily routine. Talk to your doctor about your specific test results. Narrate your complete medical history to help them correlate your clinical and laboratory findings. The test results will help the doctor determine your medical condition and formulate your treatment plan.
What is Hepatitis C Antibody (HCV), Rapid Screening Test used for?
An Hepatitis C Antibody (HCV), Rapid Screening Test test is done:
- To screen for hepatitis C infection if you have been exposed to HCV or show symptoms associated with liver disease.
- To screen for hepatitis C infection if you have risk factors for developing an HCV infection.
What does Hepatitis C Antibody (HCV), Rapid Screening Test measure?
An Hepatitis C Antibody (HCV), Rapid Screening Test test determines if HCV has infected you and helps your doctor guide your treatment. This is a rapid card based immunochromatographic test which is used for screening purposes only. A reactive result needs to be confirmed by other more specific NAT/ nucleic acid tests before final diagnosis.
HCV causes liver inflammation and is classified into acute hepatitis infection and chronic hepatitis infection.
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Acute hepatitis C: This occurs in the first six months after exposure to the hepatitis C virus. In the early stage of the infection, acute hepatitis C is mild and may cause no symptoms. For this reason, most people do not know they have this infection.
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Chronic hepatitis C: If your body cannot fight off the virus, you can develop a chronic hepatitis C infection. Progression from acute to chronic hepatitis C is common, occurring in 75-85% of patients. Detecting chronic hepatitis C early is important to prevent future complications, such as liver failure, and initiate effective treatment.
Interpreting Hepatitis C Antibody (HCV), Rapid Screening Test results
Interpretations
HCV antibody test can be reported as "positive" or "negative." If the HCV antibody test is positive, the individual tested is infected or has likely been infected with hepatitis C. If the HCV RNA test is positive, the person has a current infection. However, if no HCV viral RNA is detected, the person either does not have an active infection or the virus is very low in numbers.
HCV Antibody |
HCV RNA test |
Interpretation |
Negative |
|
There is no infection, or too early after exposure for the test to be accurate; if suspicion remains high, a retest may be required later. |
Positive or Indeterminate |
Negative |
Past infection or no infection (false positive screen); additional tests may be required |
Positive or Weak or Indeterminate |
Positive |
Current infection |