Histones

The Histones test is used to detect antibodies against histones, which are proteins that help package DNA within cells. This test is primarily used to help diagnose drug-induced lupus, a form of lupus that is triggered by certain medications. The test can also be helpful in diagnosing Systemic Lupus Erythematosus (SLE), although it is more commonly seen in drug-induced lupus. A positive result suggests the presence of antibodies against histones, which can indicate an autoimmune response, often associated with lupus. A negative result means that histone antibodies are not detected, making drug-induced lupus or lupus less likely, though it doesn't completely rule out the condition. Further tests may be needed for a more accurate diagnosis.