HLA B27 (Human Leukocyte Antigen B27) - PCR near me in Kattupakkam
Understanding HLA B27 (Human Leukocyte Antigen B27) - PCR in Kattupakkam
What is HLA B27 (Human Leukocyte Antigen B27) - PCR in Kattupakkam?
An HLA B27 (Human Leukocyte Antigen B27) - PCR test is a blood test that helps to identify the presence of Human Leukocyte Antigen B27(HLA B-27), a specific type of protein that is present on the surface of white blood cells (WBCs) that helps the body's immune system tell the difference between its own cells and foreign/harmful substances. This test is widely available with Tata 1mg labs at an affordable price in Kattupakkam
Your doctor may suggest an HLA B-27 test if you experience signs and symptoms such as stiffness and chronic pain in the back, neck, or chest, inflammation in eyes, urethra, and joints, the appearance of skin lesions, recurring fever, abdominal pain, or digestive problems indicative of an autoimmune disorder. Additionally, this test is also used during an organ transplant to match donated tissue with a transplant recipient to minimize the risk of organ rejection and improve the success of the transplantation procedure. No special preparation is needed for this test. You may eat and drink as per your daily routine.
What does HLA B27 (Human Leukocyte Antigen B27) - PCR measure?
An HLA B27 (Human Leukocyte Antigen B27) - PCR test is used to determine the presence or absence of HLA B27 antigen to rule out the possibility of an autoimmune disorder. The presence of HLA-B27 protein on the surface of white blood cells is often associated with autoimmune disorders. A positive result is associated with an increased risk of developing certain autoimmune conditions, particularly ankylosing spondylitis, reactive arthritis, and psoriatic arthritis. A negative result suggests the absence of the HLA-B27 gene variant. However, it does not rule out the possibility of developing an autoimmune disorder, as not all affected individuals carry the HLA-B27 gene.
Answers to Patient Concerns & Frequently Asked Questions (FAQs) about HLA B27 (Human Leukocyte Antigen B27) - PCR in Kattupakkam
Frequently Asked Questions about HLA B27 (Human Leukocyte Antigen B27) - PCR in Kattupakkam
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References
- Parameswaran P, Lucke M. HLA-B27 Syndromes. [Updated 2023 Jul 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551523/
- Zochling J, Bohl-Bühler MH, Baraliakos X, Feldtkeller E, Braun J. Infection and work stress are potential triggers of ankylosing spondylitis. Clin Rheumatol. 2006 Sep;25(5):660-6.[Accessed 06 Nov. 2023]. Available from: https://pubmed.ncbi.nlm.nih.gov/16633712/
- HLA- B27 Antigen [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 06 Nov. 2023]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=167&ContentID=hla_b27_antigen
- N P, Shanmugam SG, Devi SS, Chinambedu Dandapani MP, S R, D'Cruze L. Detection of Human Leukocyte Antigen B27 by Flowcytometry in Patients With Suspected Ankylosing Spondylitis in a Tertiary Care Centre. Cureus. 2021 Feb 25;13(2):e13560. [Accessed 06 Nov. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004549/#:~:text=HLA%2DB27%20testing%20is%20routinely%20used%20to%20diagnose%20AS%20since,%2Dpositive%20cases%20%5B12%5D.
- McMichael A, Bowness P. HLA-B27: natural function and pathogenic role in spondyloarthritis. Arthritis Res. 2002;4 Suppl 3(Suppl 3):S153-8. [Accessed 06 Nov. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240147/
- Ankylosing Spondylitis. [Internet]. NIH; May. 2023. [Accessed 06 Nov. 2023]. Available from: https://www.niams.nih.gov/health-topics/ankylosing-spondylitis#:~:text=Ankylosing%20spondylitis%20is%20a%20type,help%20us%20move%20and%20bend.
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