Test Detail
Understanding the Test
Test Measures
References
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Content created by
Written by
Dr. Shreya Gupta
BDS, MDS - Oral and Maxillofacial Pathology
Reviewed by
Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
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Leucocyte Esterase

You need to provide
Urine
This test is for
Male, Female
Test Preparation
  1. The urine sample must preferably be the first-morning midstream urine (part of urine that comes after the first and before the last stream). Collect the urine sample in a sealed and sterile screw-capped container provided by our sample collection professional. Ensure that the urethral area (from where the urine is passed) is clean & the container doesn't come in contact with your skin. Women are advised not to give the sample during the menstrual period unless prescribed.

Understanding Leucocyte Esterase


What is Leucocyte Esterase?

The Leucocyte Esterase test in urine detects the presence of white blood cells indicating a possible infection or inflammation in the urinary tract. This test is commonly used as a part of routine urine examination to screen for urinary tract infections (UTIs) and other inflammatory conditions in the urinary tract.

Leukocyte esterase is an enzyme released by white blood cells (leukocytes) often signifying an immune response to infection, inflammation, or other urinary tract issues. 

Doctors may suggest the Leucocyte Esterase when an individual exhibits symptoms suggestive of a urinary tract infection or other urinary issues such as pain or burning sensation during urination, frequent urination, cloudy or foul-smelling urine, and lower abdominal pain. Additionally, this test is used to monitor individuals with known urinary tract conditions or those who are at higher risk for infections, such as individuals with diabetes or a history of recurrent UTIs.

Positive leukocyte esterase results indicate the presence of white blood cells in the urine, suggesting an infection or inflammation, while negative results typically indicate no significant infection. By identifying the presence of leukocyte esterase in the urine, doctors can promptly diagnose infections, determine their severity, and initiate appropriate treatment. 

Drink enough water to provide a urine sample. A mid-stream urine sample should be collected into a sterile container provided by the sample collection professional. Women are advised not to give the sample during their menstrual period unless prescribed, as it can interfere with certain test results. Inform your doctor about all the medications or supplements that you may be taking as these may affect the test results , potentially requiring adjustments or temporary discontinuation before the test. 

Don't self-medicate at home solely based on these results and always consult a doctor for proper understanding of the test results. Narrate your complete medical history to help the doctor correlate your clinical and laboratory findings. The results will help them determine your medical condition and formulate your treatment plan.

What is Leucocyte Esterase used for?

The Leucocyte Esterase test is done:

  • As a part of routine urine examination.
  • To screen for urinary tract infections (UTIs).
  • To help diagnose kidney infections.
  • To identify inflammatory conditions of the urinary tract.
  • To monitor patients with recurrent urinary tract infections.
  • To assist in evaluating symptoms such as painful urination, frequent urination, and abdominal pain.

What does Leucocyte Esterase measure?

The Leucocyte Esterase test measures the presence of leukocyte esterase (an enzyme released by white blood cells) in urine samples, which are typically present when there is an infection or inflammation in the urinary tract. Common conditions associated with elevated leukocyte esterase levels include urinary tract infections (UTIs), kidney infections (pyelonephritis), and interstitial cystitis. When the body's immune system detects pathogens such as bacteria, it sends white blood cells to the affected area to combat the infection, leading to an increase in leukocyte esterase levels in the urine. Thus, the Leucocyte Esterase test serves as a marker for these underlying issues ensuring early detection and appropriate treatment.

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