MPO (p-ANCA)

MPO (p-ANCA) measures the autoantibodies (Perinuclear-Antineutrophil Cytoplasmic Antibodies or P-ANCA) related to an enzyme Myeloperoxidase (MPO). This test helps diagnose and monitor various autoimmune chronic inflammatory disorders and also to differentiate between different types of vasculitis like granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), lupus, rheumatoid arthritis, Wegener's granulomatosis, and Churg-Strauss syndrome. It helps evaluate treatment response in people with autoimmune diseases or vasculitis. You may get tested if you experience symptoms like joint pain and stiffness, fatigue, skin rash, shortness of breath, high blood pressure, blood in urine, etc. The test results can help guide treatment decisions, detect relapse (recurrence) in previously treated individuals, and assess disease severity to determine prognosis and treatment options.