MTHFR C677T/A1298C Mutations Detection near me in Chennai
The MTHFR C677T/A1298C Mutations Detection test is a blood test that identifies genetic variations in the MTHFR (methylenetetrahydrofolate reductase) gene. These mutations can influence how the body processes folate and homocysteine, which are crucial for cardiovascular, neurological, and reproductive health. This test helps evaluate inherited risks for conditions associated with elevated homocysteine levels and impaired folate metabolism. It is widely available in Chennai with Tata 1mg labs at an affordable price.
The MTHFR C677T/A1298C Mutations Detection test identifies genetic variations that affect folate processing and homocysteine levels, helping assess risks for cardiovascular issues, blood clots, and pregnancy complications.
This test is recommended if there are symptoms suggestive of hyperhomocysteinemia, recurrent pregnancy loss, a family history of cardiovascular disease, or unexplained blood clotting issues. It is also used to assess genetic predisposition in individuals with a history of stroke, heart attack, or vascular abnormalities. In addition, this test may be considered before or during pregnancy to guide folate supplementation and reduce the risk of neural tube defects in the fetus.
No special preparation is needed for getting the MTHFR C677T/A1298C Mutations Detection test done. However, it is preferred that you share your clinical history, current medications, and supplement use with your doctor before giving the sample, as these may influence the results.
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- Castiglia P, Sanna V, Azara A, De Miglio MR, Murgia L, Pira G, Sanges F, Fancellu A, Carru C, Bisail M, Muroni MR. Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in breast cancer: a Sardinian preliminary case-control study. Int J Med Sci. 2019 Jul 22;16(8):1089-1095. [Accessed 26 Sep. 2025]. Available from:
- MTHFR Gene Variant and Folic Acid Facts [Internet]. CDC; 27 May. 2025 [Accessed 26 Sep. 2025]. Available From:
- Molloy AM, Kirke PN, Troendle J, Burke H, Sutton M, Brody LC, Scott JM. MTHFR genotype and risk of neural tube defects: effect modification by folate intake. Circulation. 2015;132(1):52–59. [Accessed 26 Sep. 2025]. Available from:
