Nucleosomes
Understanding Nucleosomes
What is Nucleosomes?
The Nucleosomes test helps to detect the IgG antibody against nucleosomes. A Nucleosome is a structural unit that helps package DNA inside the cell. This test helps to detect systemic lupus erythematosus (SLE), which causes swelling in joints, skin, brain, lungs, kidneys, and blood vessels. You may get this test done if you have symptoms like swelling or pain in joints, headache, butterfly rashes on cheeks or nose, and fingers turning to white or blue color on cold. This test also helps to detect autoimmune hepatitis (the immune system attacks liver cells) and Sjogren’s syndrome (the immune system attacks moisture-making glands).
What does Nucleosomes measure?
The Nucleosomes test detects the presence or absence of antibodies against nucleosomes, which are structures made of DNA and proteins found in the nucleus of cells. These antibodies are often linked to autoimmune diseases, especially systemic lupus erythematosus (SLE) and drug-induced lupus. A positive result means that these antibodies are present in the blood, which may indicate an autoimmune response. A negative result in the qualitative nucleosome test means that no antibodies against nucleosomes were detected in the blood. This suggests that the person is less likely to have an autoimmune disease. However, it doesn't completely rule out other autoimmune conditions or the possibility of the disease developing later.
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