P0 (RPP)

The P0 (RPP), also known as the Ribosome P Protein antibody test, checks for antibodies that attack the P0, P1, and P2 proteins found in the 60S subunit of the ribosome. These proteins are important for making proteins inside cells. The presence of these antibodies is often seen in people with Systemic Lupus Erythematosus (SLE), especially those with neuropsychiatric symptoms like depression, confusion, or psychosis. The test is helpful for diagnosing neuropsychiatric lupus and can also indicate kidney problems in lupus patients.  A positive result suggests the presence of antibodies commonly associated with Systemic Lupus Erythematosus (SLE), while a negative result typically means these specific antibodies are not present, though it doesn’t rule out lupus or other conditions.