PCNA

The PCNA, (Proliferating Cell Nuclear Antigen) test detects antibodies against PCNA, a protein that plays a key role in DNA replication and repair. These antibodies are a rare type of antinuclear antibodies (ANA), considered highly specific for systemic lupus erythematosus (SLE), and connective tissue disorders but can also be found in viral infections, or tumors. A positive result for PCNA antibodies may suggest the presence of these autoimmune conditions. A negative result in the PCNA test means that no antibodies against the PCNA protein were detected in the blood suggesting a lower likelihood of autoimmune diseases. However, the test is not used alone for diagnosis and is typically considered alongside other clinical findings and tests to help confirm an autoimmune disorder.