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Phospholipid Antibodies Panel IgG & IgM

Also referred as

Anti Phospholipid Antibody (IgG/IgM)

APLA IgG & IgM

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2 tests

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The Phospholipid Antibodies Panel IgG & IgM is a group of blood tests that detects the levels of two antibodies: immunoglobulin G (IgG) and immunoglobulin M (IgM) against phospholipids (a type of fat found in every cell of the body). It helps diagnose a range of conditions, such as antiphospholipid syndrome (APS) or other conditions related to APS, which can increase the risk of blood clots and autoimmune disorders where the immune system mistakenly attacks the healthy cells in the body.

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Understanding Phospholipid Antibodies Panel IgG & IgM

Phospholipid antibodies are a type of abnormal protein in the blood that targets phospholipids, a type of fat that helps keep the cells healthy. These are usually made when the immune system mistakes part of the body as a threat. These antibodies are primarily associated with autoimmune conditions, particularly antiphospholipid syndrome (APS). It is a disorder that can lead to blood clots, pregnancy complications, and other health issues. These antibodies may also be seen temporarily in individuals with acute infections, human immunodeficiency virus (HIV) infection, acquired immunodeficiency syndrome (AIDS), or certain cancers. They can also occur due to medications (like phenytoin, penicillin, etc.) or without symptoms in older adults.

The Phospholipid Antibodies Panel IgG & IgM checks for two types of antibodies, IgM and IgG. It helps find the cause of unexplained blood clots, low platelet count, repeated miscarriages, early labor, and pre-eclampsia (high blood pressure during pregnancy).

Doctors may recommend the Phospholipid Antibodies Panel IgG & IgM if the patient is experiencing symptoms like pain and swelling in the limbs, shortness of breath, or headaches, which could indicate a thrombotic (blood clot) episode.

Elevated levels of IgG or IgM antibodies may suggest the presence of APS and an increased risk of thrombosis. High antibody levels are concerning when linked to symptoms like venous or arterial blood clots. Conversely, low levels of these antibodies may not necessarily indicate a health issue; they can also reflect a lack of autoimmune activity. In some cases, low or undetectable levels might occur in patients who have previously tested positive, as antibody levels can fluctuate over time.

For this test, a duly filled coagulation requisition form (Annexure - CR/05) is mandatory for sample collection. This form can be provided by the laboratory personnel (phlebotomist) before sample withdrawal. It is also recommended to discontinue heparin for 1 day and oral anticoagulants for 7 days before sample collection, or as advised by the doctor.

Lab test results may vary across laboratories. Do not try to self-medicate at home based solely on these results. Always consult a doctor for a proper understanding of the test results. The results of this test help the doctor create a treatment plan to reduce the risk of clotting and related complications.

What does Phospholipid Antibodies Panel IgG & IgM measure?

Contains 2 tests

The Phospholipid Antibodies Panel IgG & IgM measures the levels of two specific antibodies, immunoglobulin M (IgM) and IgG, that mistakenly attack phospholipids, which are important parts of cell membranes. Detecting these antibodies in the blood can indicate autoimmune diseases like antiphospholipid syndrome (APS) and lupus (SLE). Their presence in the blood is also linked to a higher risk of blood clots, such as deep vein thrombosis, pulmonary embolism, recurrent miscarriages, and strokes. Furthermore, this panel is important for diagnosing, assessing risk, and managing conditions like APS and related complications.

Anti Phospholipid Antibody IgM

The Anti Phospholipid Antibody IgM test measures the levels of the immunoglobulin M (IgM) antibodies that bind to phospholipids, essential components of cell membranes. High levels of these antibodies can undoubtedly indicate autoimmune disorders like antiphospholipid syndrome (APS), which increase the risk of thrombotic events and pregnancy complications.Therefore, this test plays a key role in diagnosing APS and assessing the risk of future blood clots.

Know more about Anti Phospholipid Antibody IgM

Anti Phospholipid Antibody, IgG

The Anti Phospholipid Antibody, IgG test measures the amount of IgG antibodies that target phospholipids, which are important parts of cell membranes. High levels of these antibodies are closely related to autoimmune diseases like antiphospholipid syndrome (APS) and lupus (SLE). These antibodies can raise the risk of blood clots, such as deep vein thrombosis (DVT), pulmonary embolism (PE), stroke, and pregnancy problems like repeated miscarriages and high blood pressure (preeclampsia). This test is crucial for diagnosing these conditions and making treatment decisions for those at risk of blood clots.

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FAQs related to Phospholipid Antibodies Panel IgG & IgM

Why is the Phospholipid Antibodies Panel IgG & IgM important?

The Phospholipid Antibodies Panel IgG & IgM is important as it helps detect autoimmune disorders, such as antiphospholipid syndrome and lupus. Early detection of these disorders allows for prompt treatment. That will prevent serious complications like clot formation and stroke.

When should I get the Phospholipid Antibodies Panel IgG & IgM?

You can get the Phospholipid Antibodies Panel IgG & IgM if you have symptoms of an autoimmune disorder, such as unexplained blood clots, recurrent miscarriages. It may also be done if you have been diagnosed with lupus to monitor your condition.

Does the Phospholipid Antibodies Panel IgG & IgM pose any risk?

No, the Phospholipid Antibodies Panel IgG & IgM is safe with minimal risks. However, you may feel slight discomfort during blood sample collection. The chances of serious complications are extremely rare.

How often should I be tested?

The frequency of tests depends on your symptoms, medical history, and the doctor's discretion. If you have a known autoimmune condition, your doctor may suggest regular testing to monitor your condition.

Do I need to fast before the Phospholipid Antibodies Panel IgG & IgM?

No, fasting is not required before the Phospholipid Antibodies Panel IgG & IgM. You can eat and drink normally.

What do high levels of phospholipid antibodies mean?

Elevated levels of IgG or IgM antibodies may indicate an increased risk of thrombosis or complications associated with APS. High levels are especially concerning when accompanied by clinical symptoms.

Can antiphospholipid antibodies be present without causing symptoms?

Yes, some individuals may test positive for antiphospholipid antibodies without any associated symptoms. This is particularly common in older adults or in cases where the antibodies are transient due to other factors, such as infections.

Is there a cure for antiphospholipid syndrome?

There is no such cure for antiphospholipid syndrome yet. However, timely and proper treatment can greatly reduce the risk of excessive and irregular blood clotting. Furthermore, consuming an anticoagulant medicine as per the doctor’s prescription can help you manage the symptoms.

How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.

Content created by

Dr. Swati Gupta (Anand)

MBBS, MD Lab Medicine

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Last Updated

22nd Oct 2025