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Anti Phospholipid Antibody, IgG

Also referred as

APL Antibody IgG

For men & women

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The Anti Phospholipid Antibody, IgG test measures the levels of immunoglobulin G (IgG) antiphospholipid antibodies (aPL) in the blood. These antibodies are formed when the immune system mistakenly targets and attacks phospholipids (the essential component of cell membranes). Once formed, these antibodies can bind to phospholipids and other proteins, leading to the activation of the blood clotting cascade and the development of antiphospholipid syndrome (APS), which increases the likelihood of abnormal blood clotting, recurrent miscarriages, and other complications.

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Understanding Anti Phospholipid Antibody, IgG

The Anti Phospholipid Antibody, IgG test measures specific IgG antibodies that are associated with antiphospholipid syndrome (APS). Identifying these antibodies is crucial for diagnosing APS, especially in cases where symptoms are unusual or accompanied by other autoimmune diseases.

The Anti Phospholipid Antibody, IgG test helps identify the cause of unexplained blood clots, low platelet levels, repeated miscarriages, preterm births, and high blood pressure during pregnancy (preeclampsia). The presence of IgG antibodies in the blood is considered a more reliable and significant sign of risk for APS and suggests a higher chance of blood clots and long-term health problems.

The Anti Phospholipid Antibody, IgG test is recommended for individuals who have had unexplained blood clots, multiple miscarriages, or other symptoms related to APS, like stroke or repeated pregnancy losses. It can also track disease activity and see how well treatment works for those already diagnosed with APS or other autoimmune conditions like lupus (SLE). The test may also be suggested for people with a history of blood clots or pregnancy problems to check the risk of future clots and help plan the right treatment, such as blood thinners. Additionally, the test can help diagnose APS in its later stages, as IgG antibodies appear at this point, showing the body’s long-term immune response.

For this test, a duly filled coagulation requisition form (Annexure - CR/05) is mandatory for sample collection. This form can be provided by the laboratory personnel (phlebotomist) before sample withdrawal. It is also recommended to discontinue heparin for 1 day and oral anticoagulants for 7 days before sample collection, or as the doctor advises.

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results. Always consult a doctor for a proper understanding of the test results. The insights from this test help the doctor tailor an appropriate treatment plan.

What does Anti Phospholipid Antibody, IgG measure?

The Anti Phospholipid Antibody, IgG test measures the amount of IgG antibodies that target phospholipids, which are important parts of cell membranes. High levels of these antibodies are closely related to autoimmune diseases like antiphospholipid syndrome (APS) and lupus (SLE). These antibodies can raise the risk of blood clots, such as deep vein thrombosis (DVT), pulmonary embolism (PE), stroke, and pregnancy problems like repeated miscarriages and high blood pressure (preeclampsia). This test is crucial for diagnosing these conditions and making treatment decisions for those at risk of blood clots.

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FAQs related to Anti Phospholipid Antibody, IgG

When should someone get the Anti Phospholipid Antibody, IgG test done?

The test is usually advised for individuals with a history of blood clots, recurrent miscarriages, or an autoimmune disease like systemic lupus erythematosus (SLE).

Does the Anti Phospholipid Antibody, IgG pose any risk?

No, the Anti Phospholipid Antibody, IgG is generally safe with minimal risks. However, you may feel slight discomfort during blood sample collection, but chances of serious complications are extremely rare.

Do I need to fast before the Anti Phospholipid Antibody, IgG?

No, fasting is not required before the Anti Phospholipid Antibody, IgG. You can eat and drink normally.

How is the Anti Phospholipid Antibody, IgG test performed?

A phlebotomist (a trained professional to perform blood draws) will clean your skin using an antiseptic alcohol cotton swab or wipe and take blood samples from your vein using a needle. The blood sample will be stored safely and transported to the laboratory for analysis.

How often should this test be done?

The frequency of testing depends on the individual’s medical history and the doctor's recommendations. It might be needed at certain intervals for monitoring patients who have had an APS.

What is meant by high levels of antiphospholipid IgG?

High levels of antiphospholipid IgG antibodies suggest a higher risk for blood clots (like deep vein thrombosis, stroke, or pulmonary embolism) and pregnancy complications (such as repeated miscarriages and preeclampsia). These elevated IgG levels are also closely linked to antiphospholipid syndrome (APS), a condition that can cause blood clotting problems and other serious health issues.

What does low antiphospholipid IgG mean?

Low levels of antiphospholipid IgG antibodies generally suggest a lack of significant risk for thrombus formation due to or risk of antiphospholipid syndrome.

Can I undergo the test during pregnancy?

Yes, this test can be conducted even during pregnancy, especially if there is a history of recurrent miscarriages or complications like preeclampsia. However, always take the doctor's guidance specific to your situation.

What other tests can be ordered with the Anti Phospholipid Antibody, IgG test?

Additional tests that may be ordered alongside the Anti Phospholipid Antibody, IgG test include: Phospholipid Antibodies Panel IgG & IgM; C-reactive protein (CRP) test; Erythrocyte sedimentation rate (ESR) test; Complete blood count (CBC) test; Coagulation tests; Protein electrophoresis test and Biopsy test.

How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.

Content created by

Dr. Swati Gupta (Anand)

MBBS, MD Lab Medicine

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Last Updated

3rd Nov 2025