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Anti Phospholipid Antibody, IgA

Also referred as

APA-IgA test

IgA antiphospholipid antibody test

For men & women

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192 hours

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The Anti Phospholipid Antibody, IgA test measures the levels of immunoglobulin A (IgA) antiphospholipid antibodies (aPL) in the blood. These antibodies are formed when the immune system mistakenly targets and attacks phospholipids (the essential component of cell membranes). Once formed, these antibodies can bind to phospholipids and other proteins, leading to the activation of the blood clotting cascade and the development of antiphospholipid syndrome (APS), which increases the likelihood of abnormal blood clotting, recurrent miscarriages, and other complications.

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Understanding Anti Phospholipid Antibody, IgA

The Anti Phospholipid Antibody, IgA test measures specific IgA antibodies that are associated with antiphospholipid syndrome (APS). Identifying these antibodies is crucial for diagnosing APS, especially in cases where symptoms are unusual or accompanied by other autoimmune diseases.

This test is usually recommended for individuals who have had unexplained blood clots, multiple miscarriages, or other signs associated with APS, such as strokes or recurrent pregnancy loss. It can differentiate between primary APS (occurs in the absence of any other autoimmune disease) and secondary APS (exists predominantly with another autoimmune disease). The test can also be used to monitor disease activity and assess treatment effectiveness in individuals diagnosed with APS or other autoimmune diseases such as systemic lupus erythematosus (SLE). It can be suggested for patients with a history of venous or arterial clotting and unexplained pregnancy complications to assess the risk of developing future blood clots and to formulate effective treatment such as anticoagulation therapy. Lastly, it may be done when an individual has a positive result for other types of antiphospholipid antibodies (APA), such as IgG or IgM, to confirm the presence and specificity of the antibodies involved.

For this test, a duly filled coagulation requisition form (Annexure - CR/05) is mandatory for sample collection. This form can be provided by the laboratory personnel (phlebotomist) before sample withdrawal. It is also recommended to discontinue heparin for a day and oral anticoagulants for 7 days before sample collection, following consultation and prior consent from the treating doctor.

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results. Always consult a doctor for a proper understanding of the test results. The insights from this test help the doctor tailor an appropriate treatment plan.

What does Anti Phospholipid Antibody, IgA measure?

The Anti Phospholipid Antibody, IgA test measures the levels of the immunoglobulin A (IgA) antibodies that bind to phospholipids, components of the cell membrane. Increased levels of IgA may indicate the presence of antiphospholipid syndrome (APS)- a condition characterized by an increased tendency to clot and cause complications in pregnancy such as miscarriage or preeclampsia. Thus, the Anti Phospholipid Antibody, IgA test assists in the diagnosis of APS and assesses the potential risk for future thrombotic events.

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FAQs related to Anti Phospholipid Antibody, IgA

What is the purpose of the Anti Phospholipid Antibody, IgA test?

The test determines the amount of IgA antibodies against phospholipids, which are integral components of the membrane structures of cells. It is mainly used for diagnosing antiphospholipid syndrome (APS) and determining its risk factor for thrombotic events (like deep vein thromboses or strokes) and complications in pregnancy (e.g., recurrent miscarriages, preeclampsia, or premature labor).

Why would I need the Anti Phospholipid Antibody, IgA test?

This test is often recommended if you have unexplained blood clots, recurrent miscarriages, or other signs of antiphospholipid syndrome (APS). However, it is particularly helpful to someone with an autoimmune disease such as systemic lupus erythematosus (SLE) in evaluating risk or as part of managing these conditions with APS.

Do I need to fast before the Anti Phospholipid Antibody, IgA?

No, fasting is not required before the Anti Phospholipid Antibody, IgA. You can eat and drink normally.

How is the Anti Phospholipid Antibody, IgA test performed?

A phlebotomist (a trained professional to perform blood draws) will clean your skin using an antiseptic alcohol cotton swab or wipe and take blood samples from your vein using a needle. The blood sample will be stored safely and transported to the laboratory for analysis.

What do the test results mean if I have high IgA levels?

High levels of anti-phospholipid IgA antibodies may suggest a greater risk of thrombotic events such as blood in the veins or arteries, as well as complications during pregnancy, mainly in individuals with APS or associated autoimmune disorders. Your doctor will evaluate the results in combination with your medical history and other tests to determine further investigations and treatment.

Does it really concern me if the Anti Phospholipid Antibody, IgA test result is positive?

Positive results do not necessarily mean you have APS or any other specific disorder. It just signifies that the body is producing antibodies to phospholipids, which could be the reason for the increased tendency to blood clots and other associated complications. Additional tests and evaluation are needed to determine the significance of the result and guide appropriate treatment.

What is the difference between anti-phospholipid IgG, IgM, and IgA?

Anti-phospholipid IgG, IgM, and IgA are all different types of antibodies targeting the phospholipids within the cell membrane. IgG is the most common antibody and may give information about a long-term or chronic immune response. IgM is generally an early sign during an immune response; it may indicate a recent or active infection. IgA is typically associated with mucosal areas such as the respiratory and gastrointestinal tracts and interfaces with local immune responses. In the context of APS, tests for each type of antibody may yield different information concerning the time of incidence, severity, and risk of complications.

What role does Anti Phospholipid Antibody, IgA play?

The Anti Phospholipid Antibody, IgA test isn't routinely performed in the first line. However, it can be helpful in selected cases when other tests such as IgG and IgM have inconclusive results.

Should I get tested for all three types (IgG, IgM, IgA)?

Testing for all three types may be recommended if your doctor suspects APS but the results from IgG or IgM alone are inconclusive. The combination of IgG, IgM, and IgA levels can provide a more comprehensive view of your immune system’s response and the potential risk for clotting events or pregnancy complications.

Can I undergo the test during pregnancy?

Yes, this test can be conducted even during pregnancy, especially if there is a history of recurrent miscarriages or complications like preeclampsia. However, always take the doctor's guidance specific to your situation.

How often should this test be done?

The frequency of testing depends on the individual’s medical history and the doctor's recommendations. It might be needed at certain intervals for monitoring patients who have had an APS.

How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.

Content created by

Dr. Swati Gupta (Anand)

MBBS, MD Lab Medicine

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Last Updated

23rd Dec 2025