PM-Scl

The PM-Scl test is used to detect antibodies against PM-Scl proteins, which are involved in the regulation of RNA and protein synthesis within cells. This test is primarily used to help diagnose Polymyositis (PM) and Systemic Sclerosis (SSc), specifically a form known as overlap syndrome, where symptoms of both diseases occur together. A positive result suggests the presence of these antibodies, which can indicate an autoimmune response affecting muscles, skin, and internal organs. A negative result means the antibodies are not detected, making these conditions less likely, though it doesn’t entirely rule them out. Additional tests may be needed to confirm the diagnosis or consider other autoimmune diseases.