PR3 (c-ANCA)
Understanding PR3 (c-ANCA)
What is PR3 (c-ANCA)?
PR3 (c-ANCA) measures the autoantibodies (Cytoplasmic-Antineutrophil Cytoplasmic Antibodies or C-ANCA) related to a protein called proteinase 3 (PR3). This test helps diagnose and monitor autoimmune diseases such as granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). A decrease in C-ANCA levels may suggest that the treatment is working. Therefore, this test helps evaluate treatment response in people with GPA or MPA. It may also be used to differentiate other conditions with similar symptoms, like infections or other autoimmune diseases. You may get tested if you experience symptoms like persistent coughing, difficulty breathing, chest pain, nosebleeds, skin rashes, sores, lumps, joint pain or swelling, fatigue, fever, and weight loss. C-ANCA test can help identify patients who may require closer monitoring or specifically guided treatment.
Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.
What does PR3 (c-ANCA) measure?
The PR3 (c-ANCA) test detects antibodies in the blood that target proteinase-3 (PR3), a protein found in certain white blood cells. These antibodies are commonly associated with autoimmune diseases like Granulomatosis with Polyangiitis (GPA), which causes inflammation in blood vessels and affects organs such as the kidneys, lungs, and sinuses. A positive PR3 (c-ANCA) test helps doctors diagnose these conditions, distinguish them from other similar health issues, and guide the appropriate treatment for better disease management.
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