Serum Ferritin
Understanding Serum Ferritin
What is Serum Ferritin?
The Serum Ferritin test measures the ferritin protein level in the blood. Ferritin is a protein that stores iron in the body. Hence, this test helps determine how much iron is stored in your body. It also helps detect diseases such as iron deficiency anemia as well as the nutritional status of an individual.
Iron is an essential mineral required for various bodily functions, including oxygen transport, energy production, and enzyme activity. It is also vital for healthy muscles, bone marrow, and other functions, including brain development in children. Ferritin, primarily concentrated in the liver and immune system cells, is responsible for storing excess iron safely. When the body needs iron, ferritin releases it into the blood for use.
The Serum Ferritin test helps detect diseases such as iron deficiency anemia, a condition characterized by low levels of iron in the body, hemochromatosis (iron overload), which can lead to organ damage (particularly the liver), and the nutritional status of an individual (concerning iron intake). It also helps monitor iron levels in individuals with chronic diseases or those receiving iron therapy.
Your doctor may advise the Serum Ferritin test when you have symptoms suggestive of altered iron levels, such as pale skin, extreme tiredness, weakness, heavy menstrual cycles, bleeding in your digestive tract, blood in your stool, shortness of breath, brittle nails, whooshing sound in your ears, and sudden spinning sensations (vertigo).
No special preparation is needed for a ferritin test; eat or drink as per your daily routine. However, talk to your doctor about all the pre-test instructions.
Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results. The test results will help them develop appropriate management plans based on your needs and circumstances.
What is Serum Ferritin used for?
The Serum Ferritin test can be done:
- To diagnose or confirm iron deficiency anemia, a condition characterized by low levels of iron in the body.
- To monitor iron levels in individuals with chronic diseases, iron overload disorders, or those receiving iron therapy.
- To assess organ function, particularly the liver, detect or monitor diseases like liver disease, restless leg syndrome, adult-onset Still’s disease, etc.
- To determine the body’s capacity to store iron.
- To assess the nutritional status, particularly concerning iron intake.
What does Serum Ferritin measure?
The Serum Ferritin test measures the concentration of ferritin in the blood. Ferritin is a protein found in cells, particularly in the liver, spleen, and bone marrow, that stores iron in a soluble or nontoxic form. When the body needs iron for essential functions like producing red blood cells and carrying oxygen, it releases iron from ferritin into the blood.
The Serum Ferritin test provides valuable information about the body's iron storage levels. Low ferritin levels may indicate iron deficiency, a condition where the body lacks enough iron to function properly. In contrast, elevated ferritin levels can indicate iron overload, a condition known as hemochromatosis. Iron overload can lead to organ damage if not adequately managed, making early detection crucial.
The Serum Ferritin test is a critical tool for assessing iron status, diagnosing iron deficiency anemia, monitoring treatment progress, detecting other iron-related disorders, and maintaining overall health.
Interpreting Serum Ferritin results
Interpretations
Normal levels:
- Adults:
- Males: 20 to 250 ng/mL
- Females 18 to 39 years age: 10 to 120 ng/mL
- Females over 40 years of age: 12 to 263 ng/mL
- Children:
- Newborns 25 to 200 ng/mL
- Infants 1 month age: 200 to 600 ng/mL
- Infants 2 to 5 months age: 50 to 200 ng/mL
- Children 6 months to 15 years age: 7 to 140 ng/mL
Ferritin test results are usually interpreted in combination with other iron tests as follows:
Iron |
TIBC |
UIBC |
Transferrin Saturation |
Ferritin |
Condition |
Low |
High |
High |
Low |
Low |
Iron Deficiency |
High |
Low |
Low |
High |
High |
Hemochromatosis, Hemosiderosis |
Low |
Low/Normal |
Low/Normal |
Low/Normal |
High/Normal |
Chronic Illness |
High |
Normal/Low |
Low/Normal |
High |
High |
Hemolytic Anemia |
Normal/High |
Normal/Low |
Low/Normal |
High |
High |
Sideroblastic Anemia |
High |
Normal |
Low |
High |
Normal |
Iron Poisoning |
A higher-than-normal level of ferritin in the blood is called hyperferritinemia.
A lower-than-normal level of ferritin in the blood is called hypoferritinemia.