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RNP-Sm antibody

RNP-Sm antibody near me in Pune

Also referred as
RNP-Sm Antibody
For men & women
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The RNP-Sm antibody test detects antibodies against Smith (Sm) and ribonucleoprotein (RNP) antigens in the blood. These antibodies are important markers for autoimmune diseases, particularly systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). The test helps support diagnosis and differentiation between different connective tissue disorders. It is widely available with Tata 1mg labs at an affordable price in Pune.

Doctors recommend the RNP-Sm antibody test when patients present with symptoms such as joint pain, skin rashes, persistent fatigue, Raynaud’s phenomenon, or muscle weakness that suggest an autoimmune condition. This test is often ordered along with other antibody tests (such as ANA, SSA, or SSB) to provide a clearer picture of the underlying autoimmune disorder.

The RNP-Sm antibody test is particularly valuable in differentiating between overlapping autoimmune diseases, confirming suspected cases of lupus or MCTD, and guiding long-term management. Detecting these antibodies at an early stage helps doctors plan further evaluation and management and follow the condition over time in selected cases. 

No special preparation is required for the RNP-Sm antibody test. However, providing the clinical history before giving the sample is preferred. 

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Blood
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Understanding RNP-Sm antibody

Sm (Smith) and RNP (U1-ribonucleoprotein) are proteins found inside cells that play a role in RNA processing. In some autoimmune conditions, the immune system mistakenly produces antibodies that target these proteins. The presence of Sm and RNP antibodies in the blood may indicate abnormal immune activity and is considered a useful marker for certain connective tissue diseases.

The Sm antibody is highly specific for systemic lupus erythematosus (SLE), though not present in all SLE patients. RNP antibodies are strongly associated with mixed connective tissue disease (MCTD). These antibodies may also be occasionally seen in other autoimmune conditions like scleroderma, Sjögren’s syndrome, or rheumatoid arthritis, though with less specificity.

Doctors recommend the RNP-Sm antibody test when patients present with symptoms such as joint pain, skin rashes, persistent fatigue, Raynaud’s phenomenon (fingers turning white/blue in cold), or muscle weakness that suggest an autoimmune condition. This test is often ordered along with other antibody tests (such as ANA, SSA, or SSB) to provide a clearer picture of the underlying autoimmune disorder.

The RNP-Sm antibody test is particularly valuable in differentiating between overlapping autoimmune diseases, confirming suspected cases of lupus or MCTD, and guiding long-term management. Detecting these antibodies at an early stage helps doctors plan further evaluation and management and follow the condition over time in selected cases. 

No special preparation is required for the RNP-Sm antibody test. Inform the doctor about all the medications and supplements currently being taken, as some of them may be relevant; do not stop medicine unless your doctor advises. However, providing the clinical history before giving the sample is preferred. 

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate and always consult a doctor to understand the test results correctly. 

Please note: This is an outsourced test. The sample is collected by TATA 1MG and processed at a NABL accredited partnered lab.

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What does RNP-Sm antibody measure?

The RNP-Sm antibody test measures the presence of antibodies that target Sm and RNP proteins within the cell nucleus. These antibodies indicate an abnormal immune reaction, where the body’s defense system attacks its own tissues.

  • Sm antibody: Highly specific for systemic lupus erythematosus (SLE). Its presence strongly supports an SLE diagnosis but does not confirm SLE by itself, though not all lupus patients test positive for it.
  • RNP antibody: Most often seen in mixed connective tissue disease (MCTD) and may also appear in lupus, scleroderma, or other autoimmune disorders.

A positive result supports the likely diagnosis of an autoimmune response and helps narrow the possibilities of the type of connective tissue disorder present. A negative result suggests that these antibodies are not detected; however, this does not completely rule out autoimmune disease, as some patients may still show clinical symptoms despite a negative test. In such cases, doctors may advise additional antibody panels or follow-up tests for accurate evaluation.

FAQs related to RNP-Sm antibody in Pune

It is a blood test that checks for antibodies against Sm and RNP proteins in the body. These antibodies are often found in people with autoimmune diseases like lupus and mixed connective tissue disease.
Sm antibodies are a type of autoantibody that target proteins inside the cell nucleus. They are considered highly specific for systemic lupus erythematosus (SLE) and help doctors confirm the diagnosis.
RNP antibodies are autoantibodies that react against ribonucleoproteins in the body. They are strongly linked with mixed connective tissue disease (MCTD) but may also be seen in lupus, scleroderma, and other autoimmune conditions.
Your doctor may suggest this test if you have symptoms such as joint pain, skin rashes, fatigue, Raynaud’s phenomenon (fingers turning white/blue in cold), or muscle weakness that may indicate an autoimmune disorder.
A blood sample is collected from a vein and analyzed using ELISA technology in the laboratory.
No, fasting is not required for this test.
Yes. In Pune, you can schedule the RNP-Sm antibody test near you with Tata 1mg Labs. The test is easy to book, cost-effective, and available with a comprehensive report.
Yes, home sample collection for the RNP-Sm antibody test is readily available in Pune. Tata 1mg Labs allows you to choose a date and time that suits your schedule for sample collection.
If you want to schedule the RNP-Sm antibody test with Tata 1mg Labs in Pune, the procedure is fairly easy and hassle-free. Follow these steps to book a test: 1). Visit the Lab Tests section on the Tata 1mg website. 2). Add the test you want to the cart. 3). Pick a time and date slot according to your convenience; however, do consider the necessary prerequisites while scheduling a test. 4). You will receive a notification with all the details once the test is scheduled.
Tata 1mg Labs is a pocket-friendly platform for booking lab tests in Pune. The RNP-Sm antibody test is available at an affordable price of Rs. 1859.
At Tata 1mg Labs, we understand the importance of timely results. We strive to provide fast turnaround times for test results, allowing you to get the information you need promptly. On average, we take 120 hours to provide the reports of the RNP-Sm antibody test in Pune.
Content created by
Written by:
Shweta Prakash
MSc, BSc
Reviewed by:
Dr. Swati Gupta (Anand)
MBBS, MD Lab Medicine
Want to know moreRead our editorial policy
Last Updated17th Feb 2026

RNP-Sm antibody test price for other cities

Price inNew DelhiRs. 1769
Price inKolkataRs. 1709
Price inHyderabadRs. 1810
Price inAligarhRs. 1429
Price inBangaloreRs. 1619

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RNP-Sm antibody