SSA-A/Ro52

The SSA-A/Ro52 test detects antibodies against the Ro52 protein, which is a component of the SS-A (Ro) antigen. These antibodies are commonly associated with autoimmune diseases such as systemic lupus erythematosus (SLE), Sjögren's syndrome, and other connective tissue disorders. A positive result for SSA-A/Ro52 antibodies can help support the diagnosis of these conditions, especially in cases where other tests, like the SS-A/Ro60 test, may not be positive. Additionally, the presence of Ro52 antibodies may be linked to a higher risk of developing complications like neonatal lupus or congenital heart block in babies born to mothers with these antibodies. However, a negative result does not completely rule out these conditions,