Stress Impact Checkup for Women near me in North 24 Parganas
Available at an affordable price with Tata 1mg labs in North 24 Parganas, the Stress Impact Checkup for Women is a comprehensive health assessment tailored to evaluate how stress affects various physiological functions and overall well-being in women. This checkup includes a range of blood tests such as vitamin B12 and vitamin D (25-hydroxy) test, complete blood count (CBC) and erythrocyte sedimentation rate (ESR) tests, diabetes screening (HbA1C and fasting blood sugar), cortisol test (morning sample), lipid profile, cardiac risk markers test, hormone tests such as follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin tests, and thyroid profile (T3, T4, TSH) to assess various metabolic, hormonal, and organ functions, aiming to identify stress-related health concerns in women
Few special preparations need to be considered before undertaking the Stress Impact Checkup for Women. You are required to submit all the samples that are a part of this package during the sample collection itself. It is noteworthy that the Stress Impact Checkup for Women test is usually conducted in the morning for accurate test results.
Understanding Stress Impact Checkup for Women
Stress management is vital for maintaining overall health and preventing long-term complications. The stress impact checkup for women offers a thorough evaluation of physiological markers influenced by stress which can trigger a cascade of hormonal and metabolic changes, influencing from blood sugar levels to immune function. Over time, these changes can contribute to the development of chronic conditions such as diabetes, cardiovascular diseases, and other hormonal disorders. This checkup includes a range of essential tests to evaluate the impact of stress on different aspects of health in women.
The Stress Impact Checkup for Women includes tests such as vitamin B12 to assess nutritional status, which can be impacted by chronic stress; complete blood count (CBC) test to provide an overview of overall blood health, helping to identify any changes in blood cell counts that might be influenced by stress; erythrocyte sedimentation rate (ESR) test to detect inflammation, which can be a response to prolonged stress; diabetes Screening (HbA1C & fasting sugar) test to monitor blood sugar levels, as stress can affect glucose metabolism and potentially lead to diabetes or worsen existing conditions; lipid profile assesses cholesterol and triglyceride levels, as chronic stress can impact cardiovascular health; vitamin D (25-Hydroxy) levels are checked since stress can influence Vitamin D metabolism and overall immune function; cardiac risk markers are also evaluated to gauge potential stress-related cardiovascular risks and thyroid profile (T3, T4, TSH) is measured since thyroid function can be influenced by stress, impacting metabolism and overall health. Additionally, this package also tests for various hormone levels, including cortisol test (morning sample), a key hormone that helps understand how the body’s stress response is functioning, as abnormal levels can indicate chronic stress or adrenal issues; and FSH, LH, and Prolactin levels to see how stress might affect reproductive hormones and menstrual cycles in women.
Few special preparations need to be considered before undertaking the Stress Impact Checkup for Women. You are required to submit all the samples that are a part of this package during the sample collection itself. It is noteworthy that the Stress Impact Checkup for Women test is usually conducted in the morning for accurate test results.
Lab results may vary, and abnormal findings should always be interpreted by a doctor for appropriate guidance. The information gathered from these tests allows doctors to offer targeted recommendations, including dietary modifications, exercise regimens, stress management techniques, and potential medical interventions if necessary.
What does Stress Impact Checkup for Women measure?
Contains 46 testsThe stress impact checkup for women includes a comprehensive assessment of various health markers to understand how stress affects the body. It includes include vitamin B12 and vitamin D (25-hydroxy) test, complete blood count (CBC) and erythrocyte sedimentation rate (ESR) tests, diabetes screening (HbA1C and fasting blood sugar), cortisol test (morning sample), lipid profile, cardiac risk markers, hormones such as follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin tests, and thyroid profile (T3, T4, TSH). These tests provide a holistic view of how stress impacts on metabolic, hormonal, and overall health, guiding effective stress management.
By identifying potential problems early and providing personalized stress management strategies, the Stress Impact Checkup for Women supports overall well-being and helps women build long-term health and resilience.
The Diabetes Screening (HbA1C & Fasting Sugar) test includes a glycosylated hemoglobin test and a glucose-fasting blood test. The glycosylated hemoglobin test measures the percentage of glycosylated hemoglobin in the blood, while a glucose-fasting blood test measures the glucose level during fasting. Glucose is the main form of sugar utilized by the body to release energy; it is absorbed by the intestine and distributed to all organs through blood. These tests help your doctor to monitor your blood sugar levels and manage your diabetes well.
Know more about Diabetes Screening (HbA1C & Fasting Sugar)
FBS (Fasting Blood Sugar)
-
No diabetes
-
Pre-diabetes (can be due to insulin resistance, and other risk factors like obesity, unhealthy diet, sedentary lifestyle, etc.)
-
Diabetes
- Eating or drinking anything (other than water) before the test
- Dehydration or prolonged fasting
- Stress or lack of sleep before testing
- Certain medications
- Sunburn
- Coffee intake
- Alcohol
- PPBS (Postprandial Blood Sugar): Measures blood sugar 2 hours after eating a meal.
- RBS (Random Blood Sugar): Measures blood sugar anytime, without fasting.
- OGTT (Oral Glucose Tolerance Test): Measures blood sugar before and after consuming glucose.
- Glycated Hemoglobin (HbA1c): Reflects average blood sugar over the past 2–3 months
The FBS (Fasting Blood Sugar) test measures the glucose level in the body under overnight fasting conditions. Glucose is the body's energy currency and is broken down through metabolism to produce energy. Hormones and enzymes produced by the liver and pancreas control this process. The hormone insulin, produced by the pancreas, regulates blood glucose levels. When these levels are high, such as after a meal, insulin is secreted to transport glucose into cells for energy production. Elevated glucose levels in the body after fasting may indicate a risk of developing prediabetes or diabetes, which can be of two types: type 1, caused by little or no insulin production, and type 2, caused by insulin resistance or decreased insulin production.
What Do the Results Mean?
Pathological Factors
|
Test Parameter |
Interpretation (possible causes) |
|
Normal |
|
|
Borderline/Elevated |
|
|
High levels |
|
Physiological Factors
🧒 Age: Glucose levels may increase slightly with age, even in healthy individuals.
🫄 Pregnancy: Hormonal changes during pregnancy can temporarily alter blood sugar levels.
Lifestyle Factors
🍽️ Diet: High sugar intake, irregular meals can affect fasting glucose readings.
😴 Sleep: Poor sleep quality, irregular sleep patterns, or chronic stress may elevate fasting glucose levels.
🚬 Smoking & Alcohol: Both can interfere with insulin function and lead to inaccurate blood sugar results.
Disclaimer: This information is for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance.
What Do Normal Fasting Blood Sugar Levels Mean?
Normal fasting blood sugar levels suggest that your body is efficiently regulating glucose through proper insulin function. It indicates a stable energy balance and a lower risk of developing diabetes or related metabolic issues.
What Do High Levels of Fasting Blood Sugar Indicate?
High fasting blood sugar levels may point to insulin resistance or reduced insulin activity in the body. It can be an early sign of prediabetes or diabetes and is often linked to factors such as poor diet, stress, inactivity, or certain health conditions.
What to Do if Your Fasting Blood Sugar Is Higher Than Normal?
If your fasting blood sugar level is higher than normal, it is important to follow up with your doctor. Many people successfully manage or reverse borderline results with healthy lifestyle changes such as balanced nutrition, regular physical activity, adequate sleep, and medical guidance when required.
What Do Low Levels of Fasting Blood Sugar Indicate?
Low fasting blood sugar levels may indicate that your body has more insulin than needed or that you have not eaten enough before the test. It can also occur due to certain medications or underlying medical conditions. Always consult your healthcare provider to understand the reason and manage it safely.
Can Fasting Blood Sugar Results Be Inaccurate?
Certain conditions or external factors such as skipping meals, lack of sleep etc., can affect FBS results. If your readings do not align with your symptoms or overall health, your doctor may recommend repeating the test or performing additional investigations to confirm accuracy.
What Factors Can Affect Fasting Blood Sugar Results?
Though a reliable test, some circumstances can influence accuracy:
What Follow-Up Tests May Be Required?
Table: Tests Commonly Ordered Alongside Fasting Blood Sugar Test:
|
Test Name |
Primary Purpose |
|
HbA1c (Glycosylated Hemoglobin) |
Measures average blood sugar over 2–3 months |
|
Postprandial Blood Sugar (PPBS) |
Checks glucose levels 2 hours after eating |
|
RBS (Random Blood Sugar) |
Measures blood sugar at any time, without the need for fasting. |
|
Oral Glucose Tolerance Test (OGTT) |
Evaluates how the body processes sugar |
|
Lipid Profile |
Evaluates cholesterol and overall heart risk |
|
Urine Microalbumin |
Detects early signs of kidney damage |
|
Liver/Kidney Function Tests |
Monitors organ health and diabetes-related complications |
|
Thyroid Profile |
Assesses metabolism and hormone balance |
How Does FBS (Fasting Blood Sugar) Differ from Other Glucose Blood Tests?
HbA1c (Glycosylated Hemoglobin)
-
Recent significant blood loss or transfusion
-
Hemolytic anemia (increased red blood cell turnover)
-
Certain hemoglobin variants interfering with test accuracy
-
Poorly controlled diabetes mellitus
-
Iron deficiency anemia
-
Chronic kidney disease
-
Hyperthyroidism (may slightly increase HbA1c)
-
Certain hemoglobinopathies affecting measurement
- Blood disorders such as anemia, sickle cell trait, or chronic blood loss
- Recent blood transfusion
- Kidney or liver diseases
- High-dose vitamin supplementation (such as vitamin C or E)
- Certain medications, including those for HIV or anemia
- Pregnancy (second and third trimester)
- Ethnic differences in hemoglobin structure (hemoglobinopathies)
The HbA1c (Glycosylated Hemoglobin) test precisely measures the percentage of sugar-coated or glycated hemoglobin in your blood. The test results represent the proportion of hemoglobin in your blood that has been glycated.
Hemoglobin, a vital protein found in red blood cells, is responsible for transporting oxygen throughout the body. Hemoglobin A is the most abundant form of hemoglobin, and when blood sugar levels increase, a higher proportion of hemoglobin A becomes glycated. As red blood cells have a lifespan of approximately 120 days, the sugar molecules remain attached to the hemoglobin for the duration of the cell's life. Consequently, the HbA1c (Glycosylated Hemoglobin) test offers insight into your average blood sugar levels over the past 8 to 12 weeks.
What Do the Results Mean?
Pathological Factors
|
Test Parameter |
Interpretation (possible causes) |
|
⇩ Low HbA1c |
|
|
⇧ High HbA1c |
|
Key: ⇧: Indicates High Levels , ⇩: Indicates Low Levels
Physiological Factors
🧒Age: HbA1c tends to increase slightly with age, even in non-diabetics.
🫄Pregnancy: HbA1c levels typically decrease due to increased red blood cell turnover, especially in the second and third trimesters.
Lifestyle Factors
🥗Diet: Consistently high sugar intake leads to elevated HbA1c over time.
😟Stress: Chronic stress can affect blood glucose levels and thus HbA1c.
😴Sleep: Poor sleep quality and sleep disorders may worsen glucose control and raise HbA1c.
🚬Smoking: Smoking can increase insulin resistance and raise HbA1c levels.
🍷Alcohol: Excessive alcohol use can cause fluctuations in blood sugar and affect HbA1c accuracy.
Disclaimer: This information is for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance.
What Do Normal HbA1c Levels Mean?
A normal HbA1c level is generally below 5.7%. This indicates that your blood sugar has been well controlled over the past 2–3 months. Staying in this range suggests your body is managing glucose effectively and helps reduce the risk of future health problems.
What High HbA1c Levels Indicate?
An HbA1c level between 5.7% and 6.4% usually suggests prediabetes, where blood sugar is higher than normal but not yet in the diabetic range. A level of 6.5% or above typically indicates diabetes.
What to Do if Your HbA1c Is Higher Than Normal?
If your HbA1c level is above the recommended range, try not to panic. Many people are able to bring it down with the right lifestyle changes, such as healthier eating, regular physical activity, and proper medication when needed. It is important to consult your doctor, who can guide you on the best steps for managing and improving your HbA1c.
What Do Low Levels of HbA1c Indicate?
Low HbA1c level (below 4%) is uncommon and may point to issues such as excess insulin use, anemia, or other conditions that shorten the lifespan of red blood cells. Since low readings can have different underlying causes, always consult a doctor to understand what they mean in your specific case.
Can HbA1c Results Be Inaccurate?
Yes. Certain conditions such as recent blood transfusion, pregnancy, liver or kidney disorders etc., can affect the test accuracy. If your results do not match your symptoms or overall health, your doctor may suggest repeating the test or additional testing. In hemoglobinopathies, where the normal form of hemoglobin (HbA1) is reduced or absent, HbA1c values may be inaccurate or may not be reported at all. In such cases, results should be interpreted along with other tests like fasting blood sugar, post-prandial blood sugar, or the Fructosamine test.
What Factors Can Affect HbA1c Results?
Though it is a reliable test, several factors can influence accuracy:
What Follow-Up Tests May Be Required?
Based on your HbA1c results, your doctor may recommend additional tests to get a clearer picture of your health or to monitor possible complications. These may include:
|
Test Name |
Primary Purpose |
|
Fasting blood sugar test /Random blood sugar test |
Measures blood sugar levels at a single point in time |
|
Lipid Profile |
Evaluates cholesterol and overall heart risk |
|
Urine Microalbumin |
Detects early signs of kidney damage |
|
Liver/Kidney Function Tests |
Monitors organ health and diabetes-related complications |
|
Thyroid Profile |
Assesses metabolism and hormone balance |
How Does HbA1c Differ from Other Blood Glucose Tests?
It is important to understand how the HbA1c (Glycosylated Hemoglobin) test differs from other common blood sugar tests:
Fasting Blood Glucose (FBS): Measures blood sugar at a single point in time, usually after 8–12 hours of fasting.
Random Blood Glucose (RBS): Measures blood sugar at any time of the day, regardless of meals, giving a quick snapshot of current levels.
Oral Glucose Tolerance Test (OGTT): Measures how the body processes sugar by checking blood glucose before and after drinking a glucose solution.
Postprandial Blood Sugar Test (PPBS): Measures blood sugar levels after a meal (usually 2 hours post eating) to assess how well the body manages glucose following food intake.
The Cortisol, Serum (Morning Sample) test measures the levels of the cortisol hormone in the blood. Cortisol is a vital hormone produced by the adrenal glands in response to stress and plays an important role in various bodily functions such as metabolism, immune response, and the body’s stress response system.
This test is conducted during the morning because cortisol levels fluctuate throughout the day, typically peaking in the early morning and gradually declining throughout the day and then into the evening. By measuring the cortisol levels in the morning, the doctors can assess the body’s natural rhythm (circadian rhythm) and evaluate how well the adrenal glands and pituitary glands are working. Deranged cortisol levels can indicate conditions such as adrenal insufficiency (Addison’s disease), cortisol excess (Cushing’s syndrome), or other disorders affecting these glands. Additionally, this test helps diagnose and monitor conditions related to stress, sleep disorders, metabolism, and overall hormone balance.
Know more about Cortisol, Serum (Morning Sample)
The Lipid Profile assesses the level of specific fat molecules called lipids in the blood and helps determine the risk of heart ailments. This profile determines the amount of different types of lipids, including total cholesterol, low-density lipoprotein (LDL) cholesterol, very-low-density lipoprotein (VLDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides. Lipids play a pivotal role in the functioning of the body. They are crucial components of the cell membranes and hormones, provide cushioning, and are a storehouse of energy. Any alterations in the lipid levels may lead to potential heart ailments, making their monitoring crucial.
Know more about Lipid Profile
Cholesterol - LDL
The Cholesterol - LDL test measures the concentration of low-density lipoprotein (LDL) cholesterol in the blood. LDL cholesterol plays an important role in your body. It carries cholesterol from your liver to other parts of the body where it's needed for things like building cell walls and making hormones. However, it is often referred to as "bad" cholesterol because when present in excess in your blood, it can stick to your blood vessel walls leading to the formation of plaque, making them narrow and less flexible. When this happens, it's harder for the blood to flow, which can lead to heart problems, like heart attacks and strokes. By measuring LDL cholesterol levels, your doctor can assess your risk of developing cardiovascular diseases and can recommend appropriate preventive or treatment strategies.
Triglycerides
The Triglycerides test measures the amount of triglycerides in the blood and helps evaluate your risk of developing cardiovascular diseases. Triglycerides are a type of fat (lipid) that your body uses as a source of energy. When you consume more calories than your body needs, the excess calories are converted into triglycerides and stored in fat cells for later use. High triglyceride levels can contribute to the hardening and narrowing of arteries, increasing the risk of heart attack, stroke, and other related conditions.
Cholesterol - Total
The Cholesterol - Total test measures the total amount of cholesterol (fats) in your blood. Cholesterol is mainly synthesized in the liver and partially in the intestines. It acts as a building block for cell membranes, is a precursor to vital hormones, and helps produce bile acids that help digest fats. Cholesterol is transported through the blood as lipoproteins: low-density lipoprotein (LDL) and high-density lipoprotein (HDL). An optimal amount of these proteins is necessary for proper body functioning.
Cholesterol - HDL
The Cholesterol - HDL test measures the concentration of high-density lipoprotein (HDL) cholesterol in the blood. HDL cholesterol plays a crucial role in maintaining cardiovascular health, as it helps transport excess low-density lipoprotein (LDL) cholesterol from the bloodstream back to the liver for excretion. This process prevents plaque buildup on the blood vessel walls, which can cause them to become narrow and less flexible. Higher HDL cholesterol levels are generally associated with a lower risk of heart problems, such as heart attacks and strokes. By measuring HDL cholesterol levels, your doctor can assess your risk of developing cardiovascular diseases and recommend appropriate preventive or treatment strategies, including lifestyle modifications and medications.
Very Low Density Lipoprotein
The Very Low Density Lipoprotein test measures the concentration of very-low-density lipoprotein (VLDL) cholesterol in the blood. VLDL cholesterol plays a vital role in the body's metabolic processes. It is produced by the liver and is used to transport triglycerides, a type of fat, from the liver to various tissues throughout the body, where they are either utilized for energy or stored for later use. Though VLDL cholesterol is essential for the body's normal functioning, it is harmful if present in excess amounts. By measuring VLDL cholesterol levels, your doctor can assess your risk of developing cardiovascular diseases and recommend appropriate preventive or treatment strategies.
Total Cholesterol/HDL Cholesterol Ratio
The Total Cholesterol/HDL Cholesterol Ratio test measures the ratio of total cholesterol and high-density lipoprotein (HDL)/good cholesterol in your blood which is a significant indicator of cardiovascular health. This ratio is calculated by dividing the total cholesterol by the HDL number. A high ratio indicates a higher amount of 'bad' cholesterol relative to 'good' cholesterol, implying a higher risk of developing heart disease. Conversely, a lower ratio implies a higher amount of 'good' cholesterol relative to 'bad' cholesterol, indicating a lower risk.
LDL/HDL Ratio
An LDL/HDL Ratio test measures the ratio of low-density lipoproteins (LDL) to high-density lipoproteins (HDL) in your blood. These two types of lipoproteins carry cholesterol throughout the body. LDL, often referred to as the 'bad' cholesterol, carries cholesterol to the cells that need it. However, if there is too much LDL cholesterol in the blood, it can combine with other substances and form plaque in the arteries, leading to cardiovascular diseases. On the other hand, HDL, often referred to as the 'good' cholesterol, helps remove other forms of cholesterol, including LDL, from the bloodstream. It transports cholesterol back to the liver, where it is broken down and eliminated from the body, thus reducing the risk of cholesterol buildup and heart disease. The LDL/HDL ratio is a significant indicator of cardiovascular health. A high ratio indicates a higher amount of 'bad' cholesterol relative to 'good' cholesterol, implying a higher risk of developing heart disease. Conversely, a lower ratio implies a higher amount of 'good' cholesterol relative to 'bad' cholesterol, indicating a lower risk.
Non HDL Cholesterol
The Non HDL Cholesterol test looks for the “bad” cholesterol particles that are likely to contribute to heart problems. These bad particles include LDL (low-density lipoprotein) cholesterol, VLDL (very-low-density lipoprotein) cholesterol, and remnants of other cholesterol-carrying molecules. Cholesterol is a waxy substance that circulates in your bloodstream and is essential for various bodily functions. However, too much of “bad” types of cholesterol can build up in your arteries and increase the risk of heart conditions. LDL and VLDL cholesterol particles are often referred to as the "bad" cholesterol because they can stick to the walls of your arteries and form plaque, narrowing the arteries and restricting blood flow to your heart. By measuring non-HDL cholesterol, your doctor can assess your risk of heart disease and determine if any interventions or lifestyle changes are needed to protect your heart.
The Thyroid Profile Total (T3, T4 & TSH) measures the circulating amounts of three key hormones:
- Total T3 (Total Triiodothyronine): T3 is the most active thyroid hormone and plays a major role in metabolism. The Thyroid Profile Total test measures both the T3 that is bound to proteins and the T3 that is free in the blood.
- Total T4 (Total Thyroxine): T4 is the primary hormone secreted by the thyroid gland. The Thyroid Profile Total test measures both protein-bound and free T4. It is a good indicator of overall thyroid hormone production.
- TSH (Thyroid Stimulating Hormone): This hormone, released by the pituitary gland, controls the production of T4 and T3 by the thyroid. It is the best screening test to determine if the thyroid is functioning normally.
What Do the Results Mean?
Pathological Factors
|
TSH |
T3 |
T4 |
Interpretation (Possible causes) |
|
High |
Normal |
Normal |
Subclinical hypothyroidism (autoimmune thyroid disease) |
|
Low |
Normal |
Normal |
Subclinical hyperthyroidism (autoimmune thyroid disease, like Graves’, etc.) |
|
High |
High |
High |
Secondary hyperthyroidism (TSH-secreting pituitary adenoma, thyroid hormone resistance syndrome, chorionic gonadotropin-secreting tumours, gestational thyrotoxicosis, etc.) |
|
Low |
Normal/High |
Normal/High |
Hyperthyroidism (Graves’ disease, etc.) |
|
Low |
Low |
Low |
Non-thyroidal illness (Sepsis, inflammatory conditions, etc.) / Secondary hyperthyroidism (TSH-secreting pituitary adenoma, Thyroid hormone resistance syndrome, Chorionic gonadotropin-secreting tumours, Gestational thyrotoxicosis, etc.) |
Note:
- Total T3 and T4 concentrations are altered by changes in thyroxine-binding globulin (TBG) capacity, which can be affected by pathological or physiological conditions.
- In pregnancy, the serum TSH reference range is different from the general population
Physiological Factors
🫄 Pregnancy: Thyroid hormone requirements increase, often leading to changes in TSH and total T4/T3 levels, especially in the first trimester.
⏱️ Time of Day: TSH levels show a circadian variation, peaking between 2 and 4 a.m. and at a minimum between 6 and 10 p.m. This variation can influence the measured serum TSH concentration.
💊Medications/Supplements: Certain drugs (like estrogen, etc.) or supplements (like biotin) can significantly alter TSH, T3, or T4 results.
🤒 Non-Thyroidal Illness (NTI): Severe illness not related to the thyroid can temporarily alter or suppress TSH and T3/T4 levels, making results difficult to interpret.
Lifestyle Factors
🧀 Diet: Severe dieting or malnutrition can decrease thyroid hormone production. Sufficient iodine intake is essential for making T3 and T4.
😴 Stress: Chronic, high-level stress may influence the hypothalamic-pituitary-thyroid axis, potentially affecting TSH regulation.
🚬 Smoking: Smoking has been linked to changes in thyroid hormone metabolism and is a risk factor for autoimmune thyroid diseases like Graves' disease.
Disclaimer: This information is for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance.
What Do Normal Thyroid Profile Results Mean?
Normal levels of TSH, total T3, and total T4 suggest that your thyroid gland is functioning correctly, producing and releasing the right amount of hormones to regulate your body's metabolism and energy.
What Do High Levels of Thyroid Profile Results Indicate?
High levels of thyroid profile results, mainly T3, T4, or a low TSH, typically indicate an overactive thyroid, known as hyperthyroidism. This condition occurs when the thyroid gland produces excess hormones, speeding up metabolism and causing symptoms such as unexplained weight loss, sensitivity to heat, irritability, mood swings, muscle weakness, hyperactivity, difficulty sleeping, etc. If you have these symptoms or abnormal lab results, it is important to consult your doctor for diagnosis and appropriate management.
What to Do if Your Thyroid Profile Results Are Higher Than Normal?
If your results are outside the normal range, consult your doctor immediately. They will evaluate your symptoms and medical history and may order follow-up tests (like free T3 or free T4) to confirm the diagnosis and determine the best course of action, which may include medication to restore hormone balance.
What Do Low Levels of Thyroid Profile Results Indicate?
Low levels in thyroid profile results, such as low T3 or T4 and high TSH, usually indicate an underactive thyroid gland or hypothyroidism. This condition slows your metabolism and can lead to symptoms like persistent fatigue, weight gain, sensitivity to cold, dry skin, thinning hair, irregular or heavier-than-usual menstrual periods, etc. If you notice these symptoms or have abnormal results, consult your doctor for further evaluation and management.
Can Thyroid Profile Results Be Inaccurate?
Yes. Sometimes, rare factors like the presence of certain antibodies or pituitary disorders can lead to discordant results that do not match your symptoms. In such cases, your doctor will suggest some additional tests to find the right diagnosis. Always consult your doctor to understand your test results correctly.
What Factors Can Affect Thyroid Profile Results?
Though a reliable test, some factors can influence accuracy:
- Biotin supplements (must be stopped 2 days before the test)
- Pregnancy
- Severe illness (non-thyroidal Illness)
- Certain medications (e.g., high-dose estrogen, etc.)
- Timings of the sample collection
- Recent changes in your thyroid medication dosage
What Follow-Up Tests May Be Required?
Table: Tests Commonly Ordered Alongside Thyroid Profile Total
|
Test Name |
Primary Purpose |
|
Free T3 and Free T4 |
Measures the active, unbound hormones to confirm the diagnosis, as they are not affected by protein binding changes (like in pregnancy) |
|
Thyroid Antibody Tests (e.g., TPO Ab) |
Helps diagnose autoimmune thyroid diseases like Hashimoto's or Graves’ disease |
|
Thyroid Scan and Uptake |
Uses a radioactive tracer to visualize the thyroid gland and assess how well it is absorbing iodine, helping to determine the cause of hyperthyroidism |
|
Thyroid Ultrasound |
Provides images of the gland to check for nodules, goiter size, or other structural abnormalities |
How Does a Thyroid Profile Differ from Other Thyroid Tests?
Thyroid Profile (TSH, Total T3, Total T4): Provides a comprehensive view at the overall function of the thyroid axis.
Free T3/T4: Measures only the biologically active, unbound portion, offering a more accurate assessment when protein levels are abnormal (e.g., pregnancy, certain medications).
Thyroid Antibody Tests: Identify whether an autoimmune response is causing the thyroid dysfunction.
Know more about Thyroid Profile Total (T3, T4 & TSH)
Thyroxine - Total (T4)
The Thyroxine - Total (T4) test measures both the bound and unbound/free form of thyroxine (T4) hormone in the blood. T4 exists in the blood in two forms: bound (attached to proteins) and free (not attached to proteins). Most of the T4 circulating in the blood is bound to proteins and only a small part is free. It is necessary to maintain a fine balance of these forms to ensure the proper functioning of the body.
Triiodothyronine - Total (T3)
The Triiodothyronine - Total (T3) test measures triiodothyronine, also known as T3, hormone that is produced by the thyroid gland. T3 hormone plays an important role in regulating the body's metabolism, energy levels, and growth & development. It exists in the blood in two forms: free T3 and bound T3. Free T3 is not bound to proteins in the blood and is the active form of T3. Whereas, bound T3 is bound to proteins, such as albumin and thyroid hormone binding globulin (THBG), which prevent it from entering the body tissues.
TSH (Thyroid Stimulating Hormone) Ultrasensitive
-
Graves’ disease (autoimmune)
-
Thyroid nodules producing excess hormones
-
Thyroiditis (inflammation of the thyroid)
-
Excess thyroid hormone therapy
-
Primary hypothyroidism (e.g., Hashimoto thyroiditis)
-
Iodine deficiency
-
Pituitary gland dysfunction (secondary hypothyroidism is rare but possible)
-
Recovery from acute illness
- Autoimmune thyroid problems like Hashimoto’s thyroiditis
- Pituitary gland disorders
- Recovery after illness or thyroid surgery
- Some medicines or a lack of nutrients
- Recheck with more thyroid tests (T3, T4, or antibodies)
- Review your medicines, diet, and health history
- Recommend thyroid hormone treatment if required
- Track symptoms like tiredness, weight gain, feeling cold, or hair loss
- Graves’ disease (autoimmune thyroid disorder)
- Thyroid nodules that produce extra hormones
- Thyroid inflammation (thyroiditis)
- Taking too much thyroid medicine
- Recent thyroid surgery or radioactive iodine treatment
- Taking biotin supplements
- Severe illness or hospitalization
- Certain medicines (like amiodarone or lithium)
- Pregnancy
The TSH (Thyroid Stimulating Hormone) Ultrasensitive test measures the levels of TSH hormone in the blood. TSH is produced by the pituitary gland located at the base of the brain. Its function is to stimulate and regulate the functioning of the thyroid gland. It signals the thyroid gland to increase or decrease the production of thyroid hormones T3 and T4 when their levels are low or high, respectively. Therefore, when the levels of T3 & T4 decrease, the pituitary gland is stimulated to release TSH. This high TSH level, in turn, stimulates the thyroid gland to release more thyroid hormones (T3 & T4). Vice versa happens when the levels of thyroid hormones increase.
What Do the Results Mean?
Pathological Factors
|
Test Result |
Interpretation |
Possible Causes / Conditions |
|
Low TSH |
Hyperthyroidism (overactive thyroid) |
|
|
High TSH |
Hypothyroidism (underactive thyroid) |
|
Physiological Factors
🧒Age: TSH may slightly increase with age.
🫄 Pregnancy: TSH levels may drop in early pregnancy because of hormonal changes.
🧑🦳 Gender: Women generally have higher TSH levels than men and are more prone to thyroid imbalances, especially during pregnancy, after childbirth, or around menopause.
⚖️ Body Weight & Metabolism: Weight gain or loss can slightly affect TSH levels.
Lifestyle Factors
🥗 Diet: Too little iodine can increase TSH, while too much may lower it.
😟 Stress: Long-term stress can disturb thyroid hormone balance.
💊 Medications: Some medicines, like steroids or lithium, can change TSH levels.
🛌 Sleep Patterns: Poor sleep can affect thyroid hormone control.
🚬 Smoking & Alcohol: Smoking may lower TSH, and too much alcohol can harm thyroid function.
🏃 Physical Activity: Regular exercise supports thyroid health, but extreme workouts can cause temporary TSH changes.
Disclaimer: This information is for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance.
What Do Normal TSH (Thyroid Stimulating Hormone) Ultrasensitive Levels Mean?
Normal TSH levels indicate that your thyroid is functioning well, producing the right amount of thyroid hormones (T3 and T4) to regulate metabolism, energy, and overall body functions. Balanced TSH suggests your body is maintaining proper hormonal balance, supporting healthy weight, energy levels, mood, and cardiovascular health.
What Do High Levels of TSH (Thyroid Stimulating Hormone) Ultrasensitive Indicate?
High TSH levels usually mean the thyroid is underactive (hypothyroidism). The pituitary gland releases extra TSH to make the thyroid produce more hormones.
Common causes include:
What to Do if Your TSH (Thyroid Stimulating Hormone) Is Higher Than Normal?
If your TSH level is high, talk to your doctor. They may:
Timely management can help control thyroid imbalances effectively.
What Do Low Levels of TSH (Thyroid Stimulating Hormone) Ultrasensitive Indicate?
Low TSH levels usually mean your thyroid is overactive (hyperthyroidism). This happens when the thyroid releases excess thyroid hormones, so the pituitary gland reduces TSH production.
Possible causes include:
If your TSH is low, your doctor may suggest more tests like T3, T4, thyroid antibody tests, or an ultrasound to find the cause and decide the right treatment.
Can TSH Results Be Inaccurate?
Yes. Certain factors such as pregnancy, recent illness, medications, or underlying pituitary or thyroid disorders can affect TSH levels and lead to inaccurate results. If your results do not match your symptoms or overall health, your doctor may suggest repeating the test or additional testing.
What Factors Can Affect TSH (Thyroid Stimulating Hormone) Ultrasensitive Results?
The TSH (Thyroid Stimulating Hormone) Ultrasensitive test is reliable, but a few factors can affect its accuracy, such as:
What Follow-Up Tests May Be Required?
Based on your TSH results, your doctor may suggest more tests to better understand your thyroid health. These tests may include:
Table: Tests Commonly Ordered Alongside TSH
|
Test Name |
Primary Purpose |
|
Free T4 (Thyroxine) |
Measures circulating thyroid hormone to assess thyroid function |
|
Free T3 (Triiodothyronine) |
Evaluates active thyroid hormone levels in the blood |
|
Anti-TPO / Anti-Tg Antibodies |
Detects autoimmune thyroid disorders like Hashimoto’s or Graves’ disease |
|
Thyroid Ultrasound |
Assesses thyroid size, nodules, and structural abnormalities |
|
Lipid Profile |
Monitors cholesterol and cardiovascular risk, which can be affected by thyroid disorders |
|
Liver/Kidney Function Tests |
Checks organ health, as thyroid imbalances can influence metabolism and organ function |
|
Hormone Assessments |
Evaluates pituitary or adrenal involvement if needed |
How Does TSH Test Differ from Other Thyroid Tests?
It is important to understand how the TSH test differs from other common thyroid tests:
TSH (Thyroid-Stimulating Hormone): Measures how much signal the pituitary gland is sending to the thyroid to make hormones.
Total T4: Measures the overall amount of thyroxine (T4) in the blood, including both bound and unbound forms, to understand thyroid hormone production.
Free T4 (FT4): Checks the active form of T4 that is available for use by the body. It helps assess how well the thyroid is functioning.
Total T3: Measures the total amount of triiodothyronine (T3), the active hormone derived from T4, often helpful in detecting hyperthyroidism.
Free T3 (FT3): Evaluates the unbound, active T3 level to understand how efficiently T4 is being converted to T3.
Thyroid Antibody Tests (TPOAb, TgAb): Identify autoimmune thyroid conditions like Hashimoto’s thyroiditis or Graves’ disease.
A Cardiac Risk Markers test measures the specific indicators called cardiac markers in the blood that can signify potential risks to heart health or cardiovascular problems. These markers provide valuable insights into an individual's risk of developing heart disease or experiencing cardiovascular events.
A Cardiac Risk Markers test includes a highly sensitive C-reactive protein test which helps indicate heart disease by detecting inflammation within the body, particularly in the blood vessels. Also, it includes testing for apolipoproteins and lipoproteins which are the essential components involved in transporting lipids (fats) through the blood. They play a vital role in the metabolism, transport, and regulation of cholesterol and other fats in the body. Their involvement is key in indicating potential heart problems.
Know more about Cardiac Risk Markers
Lipoprotein (a)
The Lipoprotein (a) test measures the amount of lipoprotein A (Lp-A) particles in your blood. Lipoprotein A is a mixture of Low-density lipoprotein (LDL) and a protein called apolipoprotein a. Lp-A levels are largely determined by genetics. Lp-A levels are not significantly affected by diet, exercise, or lifestyle changes, unlike other types of cholesterol. That is why testing for Lp-A is essential, particularly for individuals with a strong family history of cardiovascular (heart or blood vessel) disease as it is considered an independent risk factor for heart attack and stroke. This test can help identify individuals who are at high risk, enabling early intervention to prevent future complications.
hsCRP (High Sensitive CRP)
An hsCRP (High Sensitive CRP) test is a state-of-the-art biochemical marker to predict potential risks of future diseases. This test is more sensitive than the standard CRP test and can also detect lower CRP levels in the blood. Its accuracy in predicting cardiovascular issues, autoimmune disorders, and other health issues makes it an excellent test to detect asymptomatic conditions with limited diagnosis.
Apolipoprotein - A1
An Apolipoprotein - A1 test helps check the levels of Apolipoprotein A1 in your blood. Apolipoprotein A1 is the major protein for the high-density lipid (HDL), also known as “good” cholesterol and helps in its transport. Apo A1 helps the HDL to take up cholesterol from the tissues and is bound by receptors in the liver where the cholesterol is destroyed. Assessing the levels of Apolipoprotein A1 directly reflects the high-density lipoprotein levels. In this way, apolipoprotein A can help to lower your risk for cardiovascular disease.
Apolipoprotein - B
The Apolipoprotein - B test measures the level of Apo B in the blood. The protein helps in transporting fats and cholesterol within the body. Apo B is a central component of some fat-carrying particles in the blood, such as very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), and chylomicrons. It binds to LDL or "bad" cholesterol, which may result in plaque developing in the blood vessels. This accumulation can lead to heart disease, which can become grave or life-threatening if left untreated.
Apolipoprotein B/A1 Ratio
An Apolipoprotein B/A1 Ratio test helps predict the risk of cardiovascular disease (CVD) in individuals at high risk, such as those who are obese, have a family history of heart disease, have high cholesterol, or have had similar health issues in the past. Apolipoprotein A1 is the primary protein associated with HDL cholesterol (good cholesterol), and its increased concentrations are associated with a reduced risk of cardiovascular disease. Apolipoprotein B is the primary protein associated with LDL cholesterol (bad cholesterol) and other lipid molecules. An increase in LDL cholesterol is associated with increased risk of cardiovascular disease. Therefore, an Apolipoprotein B/A1 Ratio test is a key marker of developing potential cardiovascular disease (CVD) or heart-related ailments.
The FSH, LH & Prolactin test measures levels of three hormones, namely follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin, that are critical for reproductive function in males and females. This hormonal test is conducted to address various issues associated with the process of ovulation, fertility, and reproductive organs.
These hormones are important for reproductive health. Their levels help doctors understand problems with ovulation, fertility, and hormone production. In children, these hormone levels are usually low. But as puberty starts, the brain produces a hormone called GnRH, which signals the pituitary gland to release FSH and LH into the blood.
Know more about FSH, LH & Prolactin
Serum Prolactin
The Serum Prolactin test measures how much prolactin hormone is in the blood. During pregnancy, prolactin works along with estrogen and progesterone to prepare the body for breastfeeding. After delivery, prolactin helps start and maintain milk production. If a woman does not breastfeed, her prolactin levels drop soon after birth.
Besides pregnancy, the most common cause of high prolactin is a prolactinoma. It is a non-cancerous tumor in the pituitary gland. These tumors are more common in women but can also occur in men. If the tumor becomes large, it may press on the optic nerve, causing headaches and vision problems. It can also affect the production of other hormones.
Follicle Stimulating Hormone
The Follicle Stimulating Hormone test measures the level of FSH in your body. FSH is produced and subsequently released into the blood by the pituitary gland. Its production is controlled by a feedback mechanism involving a hormone situated in the hypothalamus in the brain. The released FSH travels through your blood and then attaches to receptors in the ovaries and testes. It exerts functional effects on the reproductive organs, such as sexual development, puberty, and maturation. FSH levels vary throughout the menstrual cycle in response to estradiol and progesterone. Any disruption or issue in this feedback mechanism can prevent the normal function of the testicles or ovaries. Thus, determining its level provides crucial information regarding your health.
Luteinising Hormone
The Luteinising Hormone test determines the level of luteinizing hormone that promotes the functioning of the gonads, i.e., testes in men and ovaries in women. LH is produced by the pituitary gland, a pea-sized gland situated at the base of the brain. The production and release of LH are controlled by a system known as the hypothalamic-pituitary-gonadal axis. A hormone called GnRH is released from the hypothalamus of the brain and binds to the cell receptors in the anterior pituitary gland, which in turn prompts the synthesis and release of luteinizing hormone. LH then travels across the blood and attaches to its target cells in the testes in men and ovaries in women to facilitate optimal sexual and reproductive activities.
The CBC (Complete Blood Count) test measures the number of red blood cells (RBCs), white blood cells (WBCs), and platelets. Each of these blood cells performs essential functions–RBCs carry oxygen from your lungs to the various body parts, WBCs help fight infections and other diseases, and platelets help your blood to clot. Therefore, determining their levels can provide significant health information. A CBC test also determines the hemoglobin level, a protein in RBC that carries oxygen from the lungs to the rest of your body. Evaluating all these components together can provide important information about your overall health.
Know more about CBC (Complete Blood Count)
Differential Leukocyte Count
- Differential Basophil Count
- Differential Neutrophil Count
- Differential Lymphocyte Count
- Differential Monocyte Count
- Differential Eosinophil Count
There are five types of WBCs: neutrophils, lymphocytes, monocytes, eosinophils, and basophils. A Differential Leukocyte Count test measures the percentage of each type of WBC in the blood. Leukocytes or WBCs are produced in the bone marrow and defend the body against infections and diseases. Each type of WBC plays a unique role to protect against infections and is present in different numbers.
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Red Blood Cell Count
The Red Blood Cell Count test measures the total number of red blood cells in your blood. RBCs are the most abundant cells in the blood with an average lifespan of 120 days. These cells are produced in the bone marrow and destroyed in the spleen or liver. Their primary function is to help carry oxygen from the lungs to different body parts. The normal range of RBC count can vary depending on age, gender, and the equipment and methods used for testing.
Hb (Hemoglobin)
-
Anemia
-
Decreased red cell production (e.g., chronic kidney disease, chronic inflammatory conditions, red cell aplasia, leukemias, drug toxicity, radiation therapy)
-
Infection and bone marrow failure
-
Certain congenital defects of the heart, failure of the right side of the heart (cor pulmonale),
-
Severe COPD
-
Pulmonary fibrosis and other severe lung disorders are also associated with high hemoglobin
-
Myeloproliferative neoplasms, such as polycythemia vera
- In Neonates, Hb levels are the highest. Hb levels first drop and then gradually increase until puberty.
- In healthy elderly individuals, Hb usually stays steady until around the age of 60.
- Dehydration
- High altitude
- Smoking
- Excess diuretic use
- Recent blood donation
- Hemodilution (excess IV fluids)
- Pregnancy
- Body posture
- Red Blood Cell (RBC) Count: Shows the number of red blood cells, but doesn’t indicate how well they carry oxygen.
- Hematocrit (Hct): Measures the proportion of blood made up of red cells, but not the hemoglobin content directly.
- Iron Studies (Serum Iron, Ferritin, TIBC): Assess iron levels and storage, which affect hemoglobin, but don’t directly show oxygen transport.
- Complete Blood Count (CBC): Gives overall blood cell counts, but hemoglobin specifically tells how much oxygen your blood can carry.
The Hb (Hemoglobin) test measures the concentration of hemoglobin in your blood. Hemoglobin binds oxygen molecules and carries them to body tissues while removing carbon dioxide. Low hemoglobin suggests reduced oxygen-carrying capacity. It can be due to anemia, bleeding, nutritional deficiencies (iron, vitamin B12, folate), or chronic disease. High hemoglobin may occur in dehydration, living at high altitudes, smoking, or diseases like polycythemia vera.
What Do the Results Mean?
Pathological Factors
|
Test Parameter |
Interpretation (possible causes) |
|
Low levels |
|
|
High Levels |
|
Physiological Factors
👶 Age: Age differences may cause variations in Hb levels.
🚹 Gender: Gender differences may cause variations in Hb levels, with males usually having higher values of Hb than females.
🏔️ Altitude: Higher altitudes can cause changes in Hb levels.
🤰 Pregnancy: During pregnancy, physiological changes cause a gradual decrease in the Hb levels, especially during the second trimester.
🧍 Posture: Changes in posture may impact Hb levels. For example, moving from lying to sitting can increase Hb.
🌞 Diurnal and seasonal variation: Slight fluctuations (about 3%) in Hb levels are observed throughout the day.
Lifestyle Factors
🥗 Diet: An inadequate diet, especially low intake of iron, vitamins, and folate, can lower hemoglobin levels.
🚬 Smoking: Long-term smoking can increase hemoglobin levels.
🍷 Alcohol: Excessive alcohol consumption has an increasing effect on hemoglobin levels.
🚴♀️ Exercise: Intense exercise is likely to increase hemolysis and iron metabolism and lead to the development of sports anemia.
🥤 Dehydration: Severe dehydration can apparently raise hemoglobin levels.
Disclaimer: This information is for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance.
What Do Normal Hemoglobin Levels Mean?
Normal hemoglobin levels indicate that your body has an adequate capacity to carry oxygen to tissues, ensuring proper function and energy levels.
What Do High Levels of Hemoglobin Indicate?
High hemoglobin levels may indicate chronic lung disease, high-altitude adaptation, or a rare bone marrow condition called polycythemia vera.
What to Do if Your Hemoglobin Is Higher Than Normal?
If your hemoglobin is higher than normal, your doctor will check for possible causes such as dehydration, lung or heart conditions, or increased red blood cell production. Treatment may involve staying well-hydrated, oxygen therapy, or medications to manage red blood cell levels.
What Do Low Levels of Hemoglobin Indicate?
Low hemoglobin levels may indicate anemia. It can be due to iron deficiency, blood loss, chronic illness, or nutrient deficiency (vitamin B12/folate).
Can Hemoglobin Results Be Inaccurate?
Yes, certain factors, such as improper sample handling, dehydration, recent blood transfusion, etc., can affect hemoglobin readings.
What Factors Can Affect Hb (Hemoglobin) Results?
Though it is a reliable test, some circumstances can influence accuracy:
What Follow-Up Tests May Be Required?
If your hemoglobin levels are abnormal (too low or too high), your doctor may recommend additional tests to identify the underlying cause. These follow-up investigations help determine whether anemia, dehydration, nutritional deficiency, or another health condition is responsible. These tests may include:
Table: Tests Commonly Ordered Alongside Hemoglobin Test
|
Test Name |
Primary Purpose |
| CBC (Complete Blood Count) | Provides a detailed overview of red and white blood cells and platelets |
| Serum Iron, Ferritin, TIBC | Identifies iron deficiency or overload |
| Vitamin B12 and Folate Tests | Detects deficiencies causing anemia |
| Reticulocyte Count | Evaluates bone marrow response and new red cell production |
| Hemoglobin Electrophoresis | Detects inherited blood disorders such as thalassemia or sickle cell anemia |
How Does the Hemoglobin (Hb) Test Differ from Other Blood Tests?
The Hb (Hemoglobin) test is different from other blood tests because it specifically measures the oxygen-carrying capacity of your blood, not other components:
Platelet Count
The Platelet Count test measures the average number of platelets in the blood. Platelets are disk-shaped tiny cells originating from large cells known as megakaryocytes, which are found in the bone marrow. After the platelets are formed, they are released into the blood circulation. Their average life span is 7-10 days.
Platelets help stop the bleeding, whenever there is an injury or trauma to a tissue or blood vessel, by adhering and accumulating at the injury site and releasing chemical compounds that stimulate the gathering of more platelets. A loose platelet plug is formed at the site of injury and this process is known as primary hemostasis. These activated platelets support the coagulation pathway that involves a series of steps, including the sequential activation of clotting factors; this process is known as secondary hemostasis. After this step, there is a formation of fibrin strands that form a mesh incorporated into and around the platelet plug. This mesh strengthens and stabilizes the blood clot so that it remains in place until the injury heals. After healing, other factors come into play and break the clot down so that it gets removed. In case the platelets are not sufficient in number or not functioning properly, a stable clot might not form. These unstable clots can result in an increased risk of excessive bleeding.
Total Leukocyte Count
The Total Leukocyte Count test measures the numbers of all types of leukocytes, namely neutrophil, lymphocyte, monocyte, eosinophil, and basophil, in your blood. Leukocytes or WBCs are an essential part of our immune system. These cells are produced in the bone marrow and defend the body against infections and diseases. Each type of WBC plays a unique role to protect against infections and is present in different numbers.
Hematocrit
The Hematocrit test measures the proportion of red blood cells (RBCs) in your blood as a percentage of the total blood volume. It is a crucial part of a complete blood count (CBC) and helps in assessing your blood health. RBCs are responsible for carrying oxygen from the lungs to different parts of the body. The hematocrit test provides valuable information about your blood's oxygen-carrying capacity.
Higher-than-normal amounts of RBCs produced by the bone marrow can cause the hematocrit to increase, leading to increased blood density and slow blood flow. On the other hand, lower-than-normal hematocrit can be caused by low production of RBCs, reduced lifespan of RBCs in circulation, or excessive bleeding, leading to a reduced amount of oxygen being transported by RBCs. Monitoring your hematocrit levels is essential for diagnosing and managing various blood-related disorders.
Mean Corpuscular Volume
The Mean Corpuscular Volume test measures the average size of your red blood cells, which carry oxygen through your body. This test tells whether your RBCs are of average size and volume or whether they are bigger or smaller.
Mean Corpuscular Hemoglobin
An MCH test measures the average amount of hemoglobin in a single red blood cell (RBC). Hemoglobin is an iron-containing protein in RBCs, and its major function is to transport oxygen from the lungs to all body parts. This test provides information about how much oxygen is being delivered to the body by a certain number of RBCs.
Mean Corpuscular Hemoglobin Concentration
An MCHC test measures the average amount of hemoglobin in a given volume of RBCs. MCHC is calculated by dividing the amount of hemoglobin by hematocrit (volume of blood made up of RBCs) and then multiplying it by 100.
Mean Platelet Volume
An MPV test measures the average size of the platelets in your blood. Platelets are disk-shaped tiny cells originating from large cells known as megakaryocytes, which are found in the bone marrow. After the platelets are formed, they are released into the blood circulation. Their average life span is 7-10 days.
Platelets help stop bleeding whenever there is an injury or trauma to a tissue or blood vessel by adhering and accumulating at the injury site, and by releasing chemical compounds that stimulate the gathering of more platelets. After these steps, a loose platelet plug is formed at the site of injury, and this process is known as primary hemostasis. These activated platelets support the coagulation pathway that involves a series of steps including the sequential activation of clotting factors; this process is known as secondary hemostasis. After this, there is a formation of fibrin strands that form a mesh incorporated into and around the platelet plug. This mesh strengthens and stabilizes the blood clot so that it remains in place until the injury heals. After healing, other factors come into play and break the clot down so that it gets removed. In case the platelets are not sufficient in number or are not functioning properly, a stable clot might not form. These unstable clots can result in an increased risk of excessive bleeding.
PDW
The PDW test reflects variability in platelet size, and is considered a marker of platelet function and activation (clot formation in case of an injury). This marker can give you additional information about your platelets and the cause of a high or low platelet count. Larger platelets are usually younger platelets that have been recently released from the bone marrow, while smaller platelets may be older and have been in circulation for a few days. Higher PDW values reflect a larger range of platelet size, which may result from increased activation, destruction and consumption of platelets.
RDW CV
The RDW CV test which is part of red cell indices, helps identify characteristics of red blood cells. RDW (red cell distribution width) measures the variations in the sizes of red blood cells, indicating how much they differ from each other in a blood sample. RDW is expressed as RDW-CV, a coefficient of variation. A higher RDW may suggest more variation in red cell sizes, while a lower RDW indicates more uniform red cell sizes.
Absolute Leucocyte Count
- Absolute Eosinophil Count
- Absolute Neutrophil Count
- Absolute Basophil Count
- Absolute Monocyte Count
The Absolute Leucocyte Count test measures the total number of white blood cells (leucocytes) in the given volume of blood. It examines different types of white blood cells such as neutrophils, lymphocytes, monocytes, basophils and eosinophils. These cells tell about the status of the immune system and its ability to fight off infections and other conditions like inflammation, allergies, bone marrow disorders etc.
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The ESR (Erythrocyte Sedimentation Rate) test measures how fast red blood cells (erythrocytes) settle in a tube over one hour.
When your body is inflamed, certain proteins, mainly fibrinogen, increase in the blood. These proteins cause the red blood cells to stick together in stacks. These stacks settle faster, leading to a higher ESR.
The ESR test shows that inflammation is present. However, it cannot tell you exactly where the inflammation is or what is causing it. That’s why doctors usually do this test along with other tests. This helps them understand and treat your health problems.
What Do the Results Mean?
Pathological Factors
|
Test Parameter |
Interpretation (possible causes) |
|
Normal Level |
|
|
Low Level |
|
|
High Level |
|
Physiological Factors
🧓 Age: ESR usually rises as people get older because of changes in blood proteins and red blood cells.
🚺 Gender: Women often have slightly higher ESR than men due to hormones and lower red blood cell levels.
🩸 Pregnancy and Menstruation: Both conditions can temporarily elevate ESR . THis can be due to hormonal fluctuations, increased plasma volume, and changes in fibrinogen concentration.
💊 Medications: Medicines such as dextran, methyldopa, oral contraceptives, penicillamine, procainamide, etc., can increase ESR, while aspirin, steroids, and quinine may decrease it.
Lifestyle Factors
🥗 Nutrition: Poor diet may influence plasma composition and affect ESR levels.
🚬 Smoking: Chronic smoking can increase oxidative stress and mildly raise ESR levels.
🏃 Physical Activity: Prolonged inactivity or chronic fatigue can influence inflammatory markers.
😴 Sleep and Stress: High stress or poor sleep may impact immune response and inflammation, indirectly affecting ESR.
Disclaimer: This information is for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance.
What Do Normal ESR Levels Mean?
Normal ESR levels suggest that there is no significant inflammation in the body. It means your immune system is stable and there are no ongoing infections or major inflammatory conditions.
What Do High Levels of ESR Indicate?
High ESR levels usually suggest inflammation or tissue damage in the body. They can be seen in conditions like :
- Infections
- Inflammatory arthritis
- Vasculitis (such as temporal arteritis)
- Anemia
- Kidney disease
- Tuberculosis
- Certain cancers, and plasma cell disorders
- After tissue injury (like a heart attack)
- During allergic and autoimmune reactions
What to Do if Your ESR Is Higher Than Normal?
If your ESR level is higher than normal, your doctor may recommend further tests to find the underlying cause. Treatment focuses on managing the condition causing the inflammation. Lifestyle measures like a balanced diet, proper rest, and following prescribed medications can help reduce inflammation over time.
What Do Low Levels of ESR Indicate?
Low ESR levels are less common but may occur in conditions that reduce red blood cell sedimentation. These include:
- Polycythemia vera
- Sickle cell anemia
- Congestive heart failure (CHF)
- Certain infections like typhoid, malaria, or viral illnesses
- In cases of peptic ulcer disease or acute allergic reactions
Can ESR Results Be Inaccurate?
Yes. ESR results can be affected by factors like pregnancy, anemia, infections, or certain medications. Errors in sample handling or delayed testing may also impact accuracy. Hence, results should be interpreted along with symptoms and additional test results.
What Factors Can Affect ESR (Erythrocyte Sedimentation Rate) Results?
Though a reliable test, several factors can influence accuracy:
Falsely Increased ESR:
- High fibrinogen, gamma, or beta globulins
- Age, female gender, pregnancy, or menstruation
- Infections, autoimmune disorders, or anemia
- Medications such as dextran, methyldopa, penicillamine, theophylline, vitamin A, and oral contraceptives
- Hypercholesterolemia
- High lab temperature
Falsely Decreased ESR:
- Abnormally shaped RBCs (sickle cells, spherocytes, acanthocytes)
- Microcytosis, HbC disease, or hypofibrinogenemia
- Extreme leukocytosis
- Low lab temperature or clotted blood
What Follow-Up Tests May Be Required?
If your ESR levels are high or low, your doctor may suggest additional tests to find the underlying cause. These may include:
Table: Tests Commonly Ordered Alongside ESR Test
|
Test Name |
Primary Purpose |
|
CRP (C-Reactive Protein) |
Detects active inflammation |
|
CBC (Complete Blood Count) |
Evaluates infection or anemia |
|
ANA (Antinuclear Antibody) |
Screens for autoimmune diseases |
|
Rheumatoid Factor (RF) |
Assesses for rheumatoid arthritis |
How Does ESR Differ from Other Inflammatory Tests?
It is important to understand how the ESR (Erythrocyte Sedimentation Rate) test differs from other common inflammatory tests:
- C-Reactive Protein (CRP): Detects acute inflammation and rises more quickly than ESR. It is useful for identifying infections and monitoring treatment response.
- High-Sensitivity CRP (hs-CRP): Measures low-grade inflammation and helps assess cardiovascular disease risk.
- Antinuclear Antibody (ANA): Screens for autoimmune diseases by detecting specific antibodies in the blood.
- Rheumatoid Factor (RF): Helps diagnose rheumatoid arthritis and other autoimmune disorders.
Know more about ESR (Erythrocyte Sedimentation Rate)
The Vitamin D (25-Hydroxy) test measures the levels of vitamin D in the body. Vitamin D is an essential nutrient that can be synthesized in the body upon healthy exposure to sunlight or absorbed from dietary sources. It exists in two forms: vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Vitamin D2 is present in plants, such as yeast or mushrooms, and is available as a supplement in fortified foods. Vitamin D3 is found in foods like cheese, green vegetables, mushrooms, egg yolks, and fatty fish.
Both forms of vitamin D need to be converted in the liver and kidneys before the body can use them effectively. This test shows the total level of vitamin D (D2 + D3) circulating in the body and guides your doctor in recommending the right treatment or lifestyle changes if needed.
What Do the Results Mean?
Pathological Factors
|
Test Parameter |
Interpretation (possible causes) |
|
Normal / Optimal |
Possible causes: HPT (Hyperparathyroidism) Humoral hypercalcemia of malignancy |
|
Low |
Possible causes can be renal failure, hyperphosphatemia, vitamin D–dependent rickets, types 1 and 2 |
|
Borderline / Moderate Low |
|
|
High / Excess |
Possible causes can be sarcoidosis, non-Hodgkin lymphoma |
Key: ⇧: Indicates High Levels , ⇩: Indicates Low Levels
Physiological Factors
🧒 Age: Older adults synthesize less vitamin D from sunlight primarily because of age-related changes in their skin.
🫄 Pregnancy: Vitamin D demand increases during pregnancy for fetal bone development.
💊 Hormonal Influence: Hormonal changes or contraceptive use may alter vitamin D metabolism.
Lifestyle Factors
🌤️ Sun Exposure: Limited sunlight reduces vitamin D synthesis.
🥗 Diet: Low intake of vitamin D-rich foods (like fish, egg yolks, or fortified dairy) can cause deficiency.
🍷 Alcohol Consumption: Chronic alcohol use affects liver function, impacting vitamin D metabolism.
🚬 Smoking: Smoking is closely associated with reduced bone density and altered vitamin D activity.
Disclaimer: This information is for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance.
What Do Normal Vitamin D (25-Hydroxy) Levels Mean?
Normal vitamin D levels indicate your body has sufficient vitamin D for bone health, muscle strength, and immune function.
What Do High Levels of Vitamin D (25-Hydroxy) Indicate?
High vitamin D levels may occur due to excessive supplementation or conditions like sarcoidosis or hyperparathyroidism. Persistently high levels can cause vitamin D toxicity, leading to high blood calcium (hypercalcemia), which may result in nausea, vomiting, muscle weakness, and, in severe cases, kidney stones or kidney damage.
What to Do if Your Vitamin D (25-Hydroxy) Is Higher Than Normal?
If your Vitamin D (25-Hydroxy) level is high, consult your doctor for further guidance. They may review your dosage, identify causes of high calcium like excess supplement intake, or check for conditions such as hypercalcemia. Do not stop or adjust supplements without your doctor’s advice.
What Do Low Levels of Vitamin D (25-Hydroxy) Indicate?
Low levels suggest deficiency, which may cause weak bones, muscle pain, or fatigue. Common causes include:
- Lack of sunlight exposure
- Poor dietary intake
- Malabsorption syndromes (e.g., celiac disease)
- Obesity or liver/kidney disease
Treatment involves lifestyle changes, dietary improvement, or vitamin D supplements.
Can Vitamin D (25-Hydroxy) Results Be Inaccurate?
Yes. Results may vary due to recent supplement intake, laboratory variations, or conditions affecting vitamin D metabolism, such as liver or kidney disease. In some cases, additional tests may be advised to confirm the deficiency.
What Factors Can Affect Vitamin D (25-Hydroxy) Results?
Though it is a reliable test, some circumstances can influence accuracy:
- Recent vitamin D or calcium supplement intake
- Limited sun exposure
- Chronic illness or liver/kidney disorders
- Malabsorption syndromes
- Obesity or hormonal imbalances
Know more about Vitamin D (25-Hydroxy)
The Vitamin B12 measures the amount of vitamin B12 in your blood. Vitamin B12 is important for a healthy nervous system, making red blood cells, and creating DNA in your cells. Low B12 levels are common in older adults, children, vegans or vegetarians, people with diabetes, those who had gastric bypass surgery, breastfeeding women, and people with conditions like Crohn’s disease that affect vitamin absorption. High B12 levels can occur in liver diseases, certain blood disorders, or from taking vitamin supplements. Usually, high levels from supplements are not harmful, as extra B12 is removed through urine.
What Do the Results Mean?
Pathological Factors
|
Test Parameter |
Interpretation (possible causes) |
|
Low levels |
|
|
High levels |
|
Physiological Factors
🧒 Age: Older adults may absorb less vitamin B12 due to lower stomach acid.
🫄 Pregnancy: Higher nutritional needs during pregnancy can temporarily lower B12 levels.
💊 Hormones: Hormone therapy or birth control pills can slightly affect B12 absorption.
Lifestyle Factors
🥗 Diet: Vegetarian or vegan diets without animal products may lead to low B12 intake.
🍷 Alcohol: Excessive alcohol can reduce B12 absorption and storage in the liver.
🚬 Smoking: Smoking cigarettes may reduce vitamin B12 activity.
Disclaimer: This information is for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance.
What Do Normal Vitamin B12 Levels Mean?
Normal B12 levels show that your body has enough vitamin B12 for healthy red blood cells, nerve function, and metabolism. This helps maintain energy, mood, and brain health.
What Do High Vitamin B12 Levels Mean?
High B12 levels are uncommon. They can happen due to too many supplements or health conditions like liver or kidney problems, or certain blood disorders. Your doctor may order extra tests to find the cause.
What to Do If Your Vitamin B12 Is High?
Do not stop supplements suddenly. Your doctor will review your medical history, medications, and may suggest tests to check liver, kidney, or blood health. Often, adjusting supplements is enough to bring levels back to normal.
What Do Low Levels of Vitamin B12 Indicate?
Low vitamin B12 levels suggest a deficiency, which can lead to anemia, fatigue, and nerve damage if left untreated. Common causes include:
- Poor dietary intake (especially in vegetarians or vegans)
- Malabsorption due to gastric or intestinal issues
- Pernicious anemia
- Certain medications (e.g., metformin, proton pump inhibitors)
- Treatment usually involves vitamin B12 supplements or injections based on deficiency severity.
Can Vitamin B12 Results Be Inaccurate?
Yes. While the test is reliable, results may sometimes be inaccurate due to recent vitamin B12 injections or supplements, pregnancy or hormonal therapy, liver or kidney diseases affecting vitamin metabolism, or laboratory variations in sample handling.
What Factors Can Affect Vitamin B12 Results?
Though it is a reliable test, several factors can influence accuracy:
- Recent intake of vitamin B12 supplements or injections
- Liver or kidney disorders
- Alcohol consumption or chronic illness
- Use of medications like metformin or oral contraceptives
- Pregnancy or hormonal therapy
What Follow-Up Tests May Be Required?
Based on your Vitamin B12 results, your doctor may recommend additional tests to get a clearer picture of your health or to monitor possible complications. These may include:
Table: Tests Commonly Ordered Alongside Vitamin B12
|
Test Name |
Primary Purpose |
|
Folate (Vitamin B9) Test |
Check folate levels, since low folate can also cause anemia similar to B12 deficiency. |
|
Homocysteine Test |
Measure homocysteine in the blood, which can rise when B12 is low. |
|
Methylmalonic Acid (MMA) Test |
Detect early B12 deficiency by measuring MMA, which increases when B12 is low. |
|
Complete Blood Count (CBC) Test |
Provide details about red blood cells and hemoglobin to indicate type of anemia. |
|
Intrinsic Factor Antibody Test |
Detects autoimmune causes of B12 deficiency. |
|
Gastrointestinal Absorption Tests |
Checks if the stomach or intestines are absorbing B12 properly, e.g., after gastric surgery or in conditions like Crohn’s disease. |
How Does the Vitamin B12 Test Differ from Other Blood Tests?
It is important to understand how the Vitamin B12 test differs from other common blood tests:
Complete Blood Count (CBC): Checks overall blood health and red blood cells. CBC can suggest anemia but doesn’t show the cause. Vitamin B12 specifically measures the nutrient needed to produce healthy red blood cells.
Folate (Vitamin B9) Test: Folate levels also affect red blood cell production. Unlike B12, folate deficiency alone does not directly indicate nerve or brain-related issues.
Iron Studies: Tests like serum iron or ferritin detect iron-related anemia. Vitamin B12 deficiency anemia occurs even if iron levels are normal.
Homocysteine & Methylmalonic Acid (MMA): These are functional tests that rise when B12 is low. The Vitamin B12 test directly measures the B12 level, making it the first step to detect deficiency.
Know more about Vitamin B12
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References
- 1
- 2
- 3Schneiderman N, Ironson G, Siegel SD. Stress and health: psychological, behavioral, and biological determinants. Annu Rev Clin Psychol. 2005;1:607-28. [Accessed 02 Aug. 2024]. Available From:ncbi.nlm.nih.gov/pmc/articles/PMC2568977/
- 4
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