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Last updated:
28 May 2021 | 11:59 PM (IST)
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Introduction
The Lorbriqua 25mg Tablet is used to treat adults with unresectable (unremovable), advanced, or recurrent forms of non-small cell lung cancer (NSCLC). It works by inhibiting an enzyme called anaplastic lymphoma kinase (ALK) and thus, is only given to patients who have an alteration in this enzyme (ALK-positive NSCLC). Furthermore, this tablet is prescribed only to those patients who no longer respond to other ALK inhibitors, such as alectinib or ceritinib. Additionally, it is also effective in treating ALK-positive NSCLC that has spread to the brain.
Take this medicine with or without food, but preferably at the same time each day. Depending on the condition and response to the treatment, the doctor may alter the dose or stop treatment for a short time. Continue taking this medicine for as long as the doctor has prescribed, and do not stop suddenly.
Some common side effects of the Lorbriqua 25mg Tablet include edema (swelling in arms, legs, hands, and feet), peripheral neuropathy (numbness and tingling feeling in joints, arms, and legs), and cognitive disorders (confusion, forgetfulness, and lack of concentration or attention). It may also cause breathlessness, fatigue, weight gain, joint pain, mood changes, and diarrhea. Consult the doctor if any of these side effects are worrisome or worsen. The doctor may adjust the medicine dose and suggest ways to manage them.
Let the doctor know if you have any medical conditions such as kidney or heart disease, depression, seizures, problems with the heartbeat, or breathing problems. Also, let them know if you have high blood pressure, high levels of cholesterol, or diabetes before starting treatment with this medicine. Pregnant or breastfeeding women should also consult their doctor before taking this medicine. Some other medications may affect the working of this tablet, so tell the doctor about all the other medicines you may be taking before starting the treatment with this medicine.
Take this medicine with or without food, but preferably at the same time each day. Depending on the condition and response to the treatment, the doctor may alter the dose or stop treatment for a short time. Continue taking this medicine for as long as the doctor has prescribed, and do not stop suddenly.
Some common side effects of the Lorbriqua 25mg Tablet include edema (swelling in arms, legs, hands, and feet), peripheral neuropathy (numbness and tingling feeling in joints, arms, and legs), and cognitive disorders (confusion, forgetfulness, and lack of concentration or attention). It may also cause breathlessness, fatigue, weight gain, joint pain, mood changes, and diarrhea. Consult the doctor if any of these side effects are worrisome or worsen. The doctor may adjust the medicine dose and suggest ways to manage them.
Let the doctor know if you have any medical conditions such as kidney or heart disease, depression, seizures, problems with the heartbeat, or breathing problems. Also, let them know if you have high blood pressure, high levels of cholesterol, or diabetes before starting treatment with this medicine. Pregnant or breastfeeding women should also consult their doctor before taking this medicine. Some other medications may affect the working of this tablet, so tell the doctor about all the other medicines you may be taking before starting the treatment with this medicine.
Uses of Lorbriqua 25mg Tablet
Benefits of Lorbriqua 25mg Tablet
The Lorbriqua 25mg Tablet helps shrink the size of the tumor and restricts the spread of cancer to other parts of the body. This medicine can effectively treat cancer that has spread to the brain because it can cross the blood-brain barrier. This barrier is a network of blood and tissue that prevents infectious bacteria and other harmful substances from entering the brain. The use of Lorbriqua 25mg Tablet helps prevent disease progression and reduce chances of recurrence over a long period.
Side effects of Lorbriqua 25mg Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you are worried about them.
Common side effects of Lorbriqua 25mg Tablet
- Edema (swelling in your arms, legs, hands, and feet)
- Peripheral neuropathy (numbness and tingling feeling in your joints or arms and legs)
- Cognitive disorder (decline in memory, concentration, or attention)
- Breathlessness
- Fatigue
- Weight gain
- Joint pain
- Mood changes
- Diarrhea
How to use Lorbriqua 25mg Tablet?
Take Lorbriqua 25mg Tablet in the dose and duration advised by the doctor. Swallow it as a whole. Do not chew, crush, or break it. Take this medicine with or without food.
How does Lorbriqua 25mg Tablet work?
The Lorbriqua 25mg Tablet belongs to a class of medications called kinase inhibitors. It blocks the abnormal protein anaplastic lymphoma kinase (ALK) that signals cancer cells to multiply. This way, it stops or slows the spread of cancer cells.
Safety advice
CONSULT YOUR DOCTOR
It is unknown whether it is safe to consume alcohol with Lorbriqua 25mg Tablet or not. Please consult the doctor.
UNSAFE
Lorbriqua 25mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Females of reproductive potential should use effective contraception during treatment. Consult the doctor if you are pregnant or suspect pregnancy.
UNSAFE
Lorbriqua 25mg Tablet is probably unsafe to use during breastfeeding. It might pass into breast milk and could therefore harm the baby. Avoid breastfeeding while taking this medicine and for 7-days after the last dose.
UNSAFE
Lorbriqua 25mg Tablet may cause side effects that could affect the ability to drive. Take special care when driving and using machines while on treatment with this medicine, as it can affect the mental state.
SAFE IF PRESCRIBED
Lorbriqua 25mg Tablet is safe to use in patients with kidney disease. No dose adjustment is recommended. However, the use of this medicine has not been established in patients with severe renal impairment. Consult with the doctor.
SAFE IF PRESCRIBED
Lorbriqua 25mg Tablet is safe to use in patients with liver disease. No dose adjustment is recommended. However, the use of this medicine has not been established in patients with severe hepatic impairment. Consult with the doctor.
WHAT IF YOU FORGET TO TAKE Lorbriqua 25mg Tablet ?
If you miss a dose of this medicine, skip it and continue with the usual schedule. Do not double the dose.
Quick tips
- Drink at least 8-10 glasses of water daily unless instructed otherwise.
- Do not receive any immunization or vaccination without the doctor's approval while taking this medicine.
- One may be at risk of infections. Avoid crowds or people with colds. Report fever or any other signs of infection immediately to the doctor.
- If one experiences nausea, take anti-nausea medications as prescribed by the doctor and eat small frequent meals. Sucking on lozenges and chewing gums may also help.
- Avoid sun exposure. Wear protective clothing and use sunscreen.
- Use non-hormonal contraceptives like condoms while taking this medicine as birth control pills may not be effective. After the last dose of Lobriqua Tablet, women should continue using non-hormonal contraceptives for at least 6-months, while men should continue its use for at least 3-months.
Fact Box
Chemical Class
Phenylpropanoid derivatives
Habit Forming
No
Therapeutic Class
Antineoplastic Agents
Action Class
Tyrosine Kinase Inhibitors
FAQs
Q. What should I tell my doctor before starting treatment with Lorbriqua 25mg Tablets?
Before treatment, let your doctor know if you have any other health problems related to the heart, lung, or liver. Certain medical conditions may affect your treatment and may even need dose modifications. Let your doctor know about all the other medicines you are taking because they may affect or get affected by this medicine. Inform your doctor if you are planning a baby, are pregnant, or are breastfeeding.
Q. Who should not take Lorbriqua 25mg Tablets ?
A person who is allergic to any of the ingredients present in the Lorbriqua 25mg Tablet should not take this medicine. Also, if you are taking any other medications, you must tell your doctor about them before starting treatment with this tablet. These medicines include rifampicin (used to treat tuberculosis), carbamazepine, phenytoin (used to treat epilepsy), enzalutamide (used to treat prostate cancer), etc.
Q. Do Lorbriqua 25mg Tablets increase blood sugar levels ?
Yes, the Lorbriqua 25mg Tablet may increase blood sugar levels. Talk to your doctor if you notice symptoms of increased blood sugar, such as increased thirst, urination or hunger, blurred vision, headaches, or if your breath smells fruity. Monitor your blood sugar levels regularly. Ask your doctor if you are not sure.
Q. I have developed cough and breathing issues after taking Lorbriqua 25mg Tablets. Can I continue taking it ?
Consult your doctor immediately if you have a cough, breathing problems, chest pain, or any other symptoms after taking this medicine. Your doctor will conduct a further examination to understand your symptoms and prescribe some antibiotics or other medications to resolve them if needed. If the symptoms are severe or get worsened, the doctor may discontinue your treatment too. Do not self-medicate and seek medical help if you develop any undesirable symptoms while taking this medicine.
Q. Can Lorbriqua 25mg Tablets cause liver problems? How do I know if I am having liver problems while taking Lorbriqua 25mg Tablets ?
Yes, the Lorbriqua 25mg Tablet can cause liver problems. To know whether you have liver problems while taking this medicine, you must look for signs and symptoms. These may include increased tiredness, the yellowish appearance of your skin or the white portion of your eyes, dark or brown urine, nausea, vomiting, or decreased appetite. Additionally, you may develop pain on the right side of your stomach, itching, or easy bruising too. If you observe any of these, you should consult your doctor without any delay. Your doctor will prescribe a liver function test and might reduce your dose or even suggest stopping the treatment till you recover.
Q. Can Lorbriqua 25mg Tablets cause diarrhea? How should I manage it ?
Yes, the Lorbriqua 25mg Tablet may cause diarrhea as a common side effect. If you have diarrhea after taking it, drink plenty of water and fluids to make sure you stay hydrated. Avoid taking caffeine and alcohol. Add semisolid and low-fiber foods to your diet till your bowel movements return to normal. If you feel weak, diarrhea does not resolve, or worsen, consult your doctor. Your doctor may suggest ways to cope with it or even prescribe medications to treat your symptoms.
Q. Do Lorbriqua 25mg Tablets affect fertility ?
Yes, it may affect fertility. Talk to your doctor before starting treatment to know about ways to preserve fertility.
Q. What should be done in case of an overdose of Lorbriqua 25mg Tablets ?
If you think you have overdosed, contact your doctor immediately. You may require medical attention if you take too much of this medicine.
Q. What should I do if I vomit after taking Lorbriqua 25mg Tablets ?
If you vomit after taking the Lorbriqua 25mg Tablet, take an additional dose and then take your next scheduled dose at the usual time.
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Disclaimer:
1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
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Manufacturer/Marketer address
The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.
Country of origin: United kingdom
(Inclusive of all taxes)
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