Cologenesis Colofiber-MM

Cologenesis Colofiber-MM is primarily a type 1 collagen in lyophilized particle form with mupirocin USP 2% w/w and metronidazole IP 1% W/W of specified volumes. It is gamma sterilised and supplied in convenient pet containers collofibre-MM particles possessing good absorbing characteristics and is non-toxic, non-allergenic and non-immunogenic. Colofibre-MM is useful in cases of non-healing ulcers, diabetic foot ulcers, pressure ulcers, venous ulcers, traumatic wounds, surgical wounds, and infected wounds.

Key Ingredients:

• Collagen

• Mupirocin – IP

• Metronidazole IP

Key Benefits:

• Collagen is an extracellular matrix protein that plays a major role in connective tissue. It is the most abundant protein in humans and performs multiple functions

• Collagen encourages wound healing through the deposition and organisation of freshly formed fibres and granulation tissues in the wound bed thus creating a very conducive environment for wound healing

• Topical mupirocin is very effective against S. aureus and this agent is invaluable in the eradication of staphylococci (oxford textbook of medicine 3rd edn vol 1 p 526)

• Mupriocin is an antibiotic used in various bacterial skin disorders (martindale, the extra pharmacopoeia 31st EDNP 251)

• Mupirocin is an antibacterial agent and is active against a wide range of gram-positive bacteria (PDR 55th EDN 2001 P 3075)

• Metronidazole topical cream is indicated in the treatment of gram-negative bacterial infections (PDR 55th EDN 2001 p 291)

• Topical formulations of metronidazole have proved effective in various skin disorders (Martindale the extra Pharmacopoeia p 624)

• Metronidazole is a member of the imidazole class of antibacterial agents and is classified as an antibacterial (PDR 55th EDN 2001 p 1115)

• Metronidazole has been used to manage anaerobic infections (oxford textbook of medicine 3rd edv vol 1 p 575)

Directions For Use:

• Assess, debride and clean the wound according to your protocols

• Apply collofibre-MM particles sufficiently to cover the wound

• With a heavily draining wound cover it with an absorbent dressing and change as necessary

• With a minimal draining wound cover with a secondary non-absorbent dressing and change as required

• Remove the secondary dressing daily as indicated by the amount of draining

• If dressing is adhered to the wound, irrigate with saline until the dressing loosens and lift gently

• Reapply collofibre-MM particles as before

• Wounds may appear larger during the first several days of treatment due to the reduction of oedema

• An increase in drainage may be seen in the several days of treatment

• Treatment of the underlying conditions as well as nutritional support should proceed concurrently with the use of collofibre-MM

Safety Information:

• Avoid topical agents like povidone iodine, H2O2 and sodium hypochlorite for cleansing the wound as their toxicity level may hamper the new tissue growth

• Collofibre-MM particles are single-use products which should not be resterilized

• Store in a cool and dry place away from direct sunlight

• Read the product label carefully before use

• Keep out of reach of children