Adcapone Tablet is used in the treatment of Parkinson's disease. It helps to treat wearing-off symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control.
Adcapone Tablet is usually used in combination with carbidopa/levodopa. It may be taken with or without food, preferably at bedtime. However, take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor.
If you have missed a dose, take it as soon as you remember it. This medication mustn't be stopped suddenly without talking to the doctor as it may worsen your condition. Your doctor may advise for periodic skin examination as it can cause melanoma.
Some common side effects of this medicine include nausea, vomiting, fatigue, confusion, constipation, insomnia (difficulty sleeping), nightmares, and increased sweating. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. It is common to have diarrhea with this medicine, so drink plenty of fluids and watch for weight loss. Inform your doctor if you develop any unusual changes in mood, an abnormally high sex drive, and hallucinations. It may cause your urine to change in a brownish-orange color but it is not harmful and usually resolves once treatment is completed. Please consult your doctor if these side effects worry you or do not go away.
Adcapone Tablet is one of the most effective medications to relieve symptoms of Parkinson's disease such as tremors, muscle stiffness and difficulty moving. It increases the amount of a chemical called dopamine in the brain which helps in the coordination of body movements. This medicine can therefore enhance the quality of life by improving the ability to carry out daily functions in a better manner.
Side effects of Adcapone Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Adcapone
Nausea
Vomiting
Fatigue
Confusion
Constipation
Insomnia (difficulty in sleeping)
Nightmares
Hallucination
Dizziness
Diarrhea
Muscle coordination impaired
Abdominal pain
Dryness in mouth
How to use Adcapone Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Adcapone Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Adcapone Tablet works
Adcapone Tablet is a selective reversible inhibitor that is given in combination with levodopa. It works by inhibiting a chemical messenger [catechol-O-methyl transferase (COMT)] which in turn helps in increasing the amount of dopamine (chemical messenger) in the brain. Thus, an adequate amount of dopamine in the brain helps to coordinate body movements.
Safety advice
Alcohol
UNSAFE
Adcapone Tablet may cause excessive drowsiness with alcohol.
Pregnancy
CONSULT YOUR DOCTOR
Adcapone Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Adcapone Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
CAUTION
Adcapone Tablet may cause dizziness or weakness due to low blood pressure. Do not drive if these symptoms occur.
Kidney
SAFE IF PRESCRIBED
Adcapone Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Adcapone Tablet may not be needed in these patients. Please consult your doctor.
Liver
UNSAFE
Adcapone Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
What if you forget to take Adcapone Tablet?
If you miss a dose of Adcapone Tablet, skip it and continue with your normal schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
You have been prescribed Adcapone Tablet to enhance the effectiveness of levodopa for the treatment of Parkinson's disease.
It can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
Inform your doctor if you develop impulsive, unusual behavior and/or an abnormally high sex drive.
Talk to your doctor in case you develop hallucinations or other changes in your behavior.
It is common to have diarrhea with this drug. Therefore, drink plenty of fluids and watch for weight loss.
Do not get worried if you notice a reddish-brown discoloration in your urine as it is harmless in nature.
Do not stop taking the medication suddenly without talking to your doctor.
Fact Box
Chemical Class
Hydroxycinnamic Acids Derivatives
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
COMT inhibitors
Patient concerns
Parkinson's disease tremors ,Insomnia.
Dr. Ravi Shankar M.
Ayurveda
Use Dhanadanayanadi kashayam 15ml twice a day with 15 ml water before food and Zandopa 10 grams twice a day witk milk after food and Tab Dhanvantari Vati 1-0-1 after food for 2 months
My mother suffering from Parkinson disease from 7 year , any affective medicine ?? Both hand and leg is shaking ,hardly stand up from bed himself, using parking tablet, syndopa plus and parkitidin
Dr. Saurav Arora
Homeopathy
Dear sir Parkinson's can only be managed with Homeopathy. There are few medicines which are used to improve quality of life and decrease disease progression
My mother takes syndopa 275 and pacitone together for 2 times a day. And syndopa 275 alone at night. With these she takes adcapone. She sometimes gets confused. She even cannot remember the day or things she has done earlier in the day. Should i stop pacitone or syndopa. Please suggest
Dr. Vikas Sharma
Neurology
try stopping pacitane and see if it helps; better review with a neuro
At times my fingers shiver when I hold cup, paper etc it's subconscious as in I do not notice it person Accompanying me notices I have no other health issues. Does this indicate Parkinson's disease? How is it diagnosed?
My father has parkinson's disease from last 12 year. In last 2012 he got severe pneumonia and has been admitted in AIIMS .He was treated with various antibiotics.he came out but got bed ridden after that.From last few year he just sit on his own. he is currently taking bexol 1mg three times, syndopa 125 plus 3 times, ropark XL 3 times.now from few year he got hallucination and cound not sleep in night and constantly talking in night(Some Nights not always).During his stay in AIIMS Dr. prescribed quetiapine 12.5 mg which he is not currently taking.please advice some medicien so that he atleast can sleep at night.
What were the side-effects while using Adcapone Tablet?
No Side Effec*
33%
Fatigue
33%
Constipation
33%
*No Side Effect
How do you take Adcapone Tablet?
With or witho*
67%
With food
33%
*With or without food
Please rate Adcapone Tablet on price
Average
78%
Not Expensive
22%
FAQs
Can Adcapone Tablet be crushed or split? If not, then how it should be taken?
No, Adcapone Tablet should not be crushed or split. Take it as a whole with a full glass of water at the same time as you take a dose of levodopa
Does Adcapone Tablet have any effect on urine color?
Yes, Adcapone Tablet may cause your urine to change to a brownish-orange color. This effect is common and is not harmful.
Will Adcapone Tablet make me sleepy?
The combined use of Adcapone Tablet and levodopa has been associated with cases of excessive daytime sleepiness and sudden sleep onset episodes. If you experience these symptoms, then you should neither drive nor operate other complex machinery. Consult your doctor if it becomes troublesome.
What is meant by impulse control disorder caused by Adcapone Tablet?
In impulse control disorders, you may get urges or cravings to behave in ways that are unusual for you. In such disorders, you cannot resist the impulse, drive or temptation to carry out certain activities that could harm yourself or others. Additionally, it may include addictive gambling, excessive eating or spending, an abnormally high sex drive or a preoccupation with an increase in sexual thoughts or feelings. In such a case, your doctor may suggest dose reduction or discontinuation of dose.
What if I accidentally take more than the recommended doses of Adcapone Tablet?
In case you take more than the recommended doses of Adcapone Tablet, you may experience confusion, decreased activity, sleepiness, decreased muscle tone, skin discoloration, and urticaria. If any such symptoms occur, you should seek immediate medical attention in a nearby hospital or contact your doctor.
Does Adcapone Tablet cross the blood-brain barrier?
No, Adcapone Tablet does not cross the blood-brain barrier. It is useful in prolonging the duration of the benefit obtained from individual doses of levodopa.
Does Adcapone Tablet affect fertility?
No, Adcapone Tablet does not affect fertility. However, it should be avoided by pregnant and lactating women because there is no sufficient data to support the safety of this patient group.
Is Adcapone Tablet a dopamine agonist?
No, it is not a dopamine agonist. Adcapone Tablet is a selective and reversible inhibitor of COMT (catechol-O-methyltransferase) which works by increasing and maintaining sustained levels of levodopa when levodopa is given along with it.
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References
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 473-74.
Entacapone. Espoo, Finland: Orion Corporation; 2000 [revised Jun. 2014]. [Accessed 25 Mar. 2019] (online) Available from:
Merello M, Lees AJ, Webster R, et al. Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 1994;57(2):186-89. [Accessed 19 Jun. 2019] (online) Available from:
Entacapone. North Ryde, New South Wales: Novartis Pharmaceuticals
Australia Pty Limited; 2013. [Accessed 19 Jun. 2019] (online) Available from:
MedlinePlus. Entacapone. [Accessed on 25 Mar. 2019] (online) Available from:
Entacapone [Prescribing Information]. East Hanover, N.J: Novartis Pharmaceuticals Corporation; 2020. [Accessed 25 Jul. 2024] (online) Available from:
Marketer details
Name: Sun Pharmaceutical Industries Ltd
Address: Plot no 107/108,Namli block , Ranipool, East Sikkim 737135
Country of origin: India Expires on or after: November, 2025
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