Entacom Tablet
Prescription Required
Product introduction
Entacom Tablet is used in the treatment of Parkinson's disease. It helps to treat wearing-off symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control.
Entacom Tablet is usually used in combination with carbidopa/levodopa. It may be taken with or without food, preferably at bedtime. However, take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor.
If you have missed a dose, take it as soon as you remember it. This medication mustn't be stopped suddenly without talking to the doctor as it may worsen your condition. Your doctor may advise for periodic skin examination as it can cause melanoma.
Some common side effects of this medicine include nausea, vomiting, fatigue, confusion, constipation, insomnia (difficulty sleeping), nightmares, and increased sweating. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. It is common to have diarrhea with this medicine, so drink plenty of fluids and watch for weight loss. Inform your doctor if you develop any unusual changes in mood, an abnormally high sex drive, and hallucinations. It may cause your urine to change in a brownish-orange color but it is not harmful and usually resolves once treatment is completed. Please consult your doctor if these side effects worry you or do not go away.
Uses of Entacom Tablet
Side effects of Entacom Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Entacom
- Nausea
- Vomiting
- Fatigue
- Confusion
- Constipation
- Insomnia (difficulty in sleeping)
- Nightmares
- Hallucination
- Dizziness
- Diarrhea
- Muscle coordination impaired
- Abdominal pain
- Dryness in mouth
How to use Entacom Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Entacom Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Entacom Tablet works
Entacom Tablet is a selective reversible inhibitor that is given in combination with levodopa. It works by inhibiting a chemical messenger [catechol-O-methyl transferase (COMT)] which in turn helps in increasing the amount of dopamine (chemical messenger) in the brain. Thus, an adequate amount of dopamine in the brain helps to coordinate body movements.
Safety advice
Alcohol
UNSAFE
Entacom Tablet may cause excessive drowsiness with alcohol.
Pregnancy
CONSULT YOUR DOCTOR
Entacom Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Entacom Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
CAUTION
Entacom Tablet may cause dizziness or weakness due to low blood pressure. Do not drive if these symptoms occur.
Kidney
SAFE IF PRESCRIBED
Entacom Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Entacom Tablet may not be needed in these patients. Please consult your doctor.
Liver
UNSAFE
Entacom Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
What if you forget to take Entacom Tablet?
If you miss a dose of Entacom Tablet, skip it and continue with your normal schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Entacom Tablet
₹9.0/Tablet
Adcapone Tablet
Sun Pharmaceutical Industries Ltd
₹9.5/tablet
6% costlier
Adcopas 200mg Tablet
Eris Lifesciences Ltd
₹6.72/tablet
25% cheaper
Quick tips
- You have been prescribed Entacom Tablet to enhance the effectiveness of levodopa for the treatment of Parkinson's disease.
- It can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- Inform your doctor if you develop impulsive, unusual behavior and/or an abnormally high sex drive.
- Talk to your doctor in case you develop hallucinations or other changes in your behavior.
- It is common to have diarrhea with this drug. Therefore, drink plenty of fluids and watch for weight loss.
- Do not get worried if you notice a reddish-brown discoloration in your urine as it is harmless in nature.
- Do not stop taking the medication suddenly without talking to your doctor.
Fact Box
Chemical Class
Hydroxycinnamic Acids Derivatives
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Catechol-O-Methyltransferase (COMT) Inhibitors
Interaction with drugs
Taking Entacom with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Entacapone may raise blood levels of Apomorphine.
If concurrent use is essential, your doctor may monitor Apomorphine levels along with your overall treatment and adjust the doses
Concurrent use may cause disturbances in heart rhythm.
Your doctor may monitor your treatment and adjust the doses as per the observations.
Concurrent use may cause disturbances in heart rhythm.
Your doctor may monitor your treatment and adjust the doses as per the observations.
Imipramine may reduce blood levels and/or fasten the elimination of Entacapone.
Talk to your doctor if you notice any unusual symptoms.Doctor may monitor your liver function.
Entacapone may raise blood levels of Apomorphine.
If concurrent use is essential, your doctor may monitor Apomorphine levels along with your overall treatment and adjust the doses
Patient concerns
User feedback
Patients taking Entacom Tablet
Twice A Day
40%
Four Times A *
20%
Thrice A Day
20%
Once A Day
20%
*Four Times A Day
What are you using Entacom Tablet for?
Parkinson's d*
100%
*Parkinson's disease
How much was the improvement?
Average
50%
Poor
50%
What were the side-effects while using Entacom Tablet?
Nausea
40%
No Side Effec*
20%
Confusion
20%
Constipation
20%
*No Side Effect
How do you take Entacom Tablet?
Empty stomach
67%
With food
33%
Please rate Entacom Tablet on price
Average
33%
Expensive
33%
Not Expensive
33%
FAQs
Can Entacom Tablet be crushed or split? If not, then how it should be taken?
No, Entacom Tablet should not be crushed or split. Take it as a whole with a full glass of water at the same time as you take a dose of levodopa
Does Entacom Tablet have any effect on urine color?
Yes, Entacom Tablet may cause your urine to change to a brownish-orange color. This effect is common and is not harmful.
Will Entacom Tablet make me sleepy?
The combined use of Entacom Tablet and levodopa has been associated with cases of excessive daytime sleepiness and sudden sleep onset episodes. If you experience these symptoms, then you should neither drive nor operate other complex machinery. Consult your doctor if it becomes troublesome.
What is meant by impulse control disorder caused by Entacom Tablet?
In impulse control disorders, you may get urges or cravings to behave in ways that are unusual for you. In such disorders, you cannot resist the impulse, drive or temptation to carry out certain activities that could harm yourself or others. Additionally, it may include addictive gambling, excessive eating or spending, an abnormally high sex drive or a preoccupation with an increase in sexual thoughts or feelings. In such a case, your doctor may suggest dose reduction or discontinuation of dose.
What if I accidentally take more than the recommended doses of Entacom Tablet?
In case you take more than the recommended doses of Entacom Tablet, you may experience confusion, decreased activity, sleepiness, decreased muscle tone, skin discoloration, and urticaria. If any such symptoms occur, you should seek immediate medical attention in a nearby hospital or contact your doctor.
Does Entacom Tablet cross the blood-brain barrier?
No, Entacom Tablet does not cross the blood-brain barrier. It is useful in prolonging the duration of the benefit obtained from individual doses of levodopa.
Does Entacom Tablet affect fertility?
No, Entacom Tablet does not affect fertility. However, it should be avoided by pregnant and lactating women because there is no sufficient data to support the safety of this patient group.
Is Entacom Tablet a dopamine agonist?
No, it is not a dopamine agonist. Entacom Tablet is a selective and reversible inhibitor of COMT (catechol-O-methyltransferase) which works by increasing and maintaining sustained levels of levodopa when levodopa is given along with it.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 473-74.
- Entacapone. Espoo, Finland: Orion Corporation; 2000 [revised Jun. 2014]. [Accessed 25 Mar. 2019] (online) Available from:
- Entacapone. Newbury, Berkshire: Orion Pharma (UK) Limited; 1998 [revised 15 Dec. 2016]. [Accessed 28 Jan. 2019] (online) Available from:
- Merello M, Lees AJ, Webster R, et al. Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 1994;57(2):186-89. [Accessed 19 Jun. 2019] (online) Available from:
- Entacapone. North Ryde, New South Wales: Novartis Pharmaceuticals Australia Pty Limited; 2013. [Accessed 19 Jun. 2019] (online) Available from:
- MedlinePlus. Entacapone. [Accessed on 25 Mar. 2019] (online) Available from:
- Entacapone [Prescribing Information]. East Hanover, N.J: Novartis Pharmaceuticals Corporation; 2020. [Accessed 25 Jul. 2024] (online) Available from:
Marketer details
Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Country of origin: India
Expires on or after: April, 2026
A licensed vendor partner from your nearest location will deliver Entacom Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Expires on or after: April, 2026
A licensed vendor partner from your nearest location will deliver Entacom Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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