Clogest 500mg Injection

Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS

Last updated on 25 Nov 2025 | 03:05 PM (IST)

Clogest 500mg Injection is used to prevent premature labor in pregnant women in order to reduce the risk of giving birth too early (preterm birth). It prevents miscarriage and lowers the risk of premature birth in women who have had one premature delivery in the past.

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Clogest 500mg Injection

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Hydroxyprogesterone (500mg)

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General Information

Contains

Hydroxyprogesterone (500mg)

Marketer

Mediclove Biotech Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Clogest 500mg Injection is administered only by or under the supervision of a doctor. It should be taken as your doctor advice. Your doctor will decide how much you need to take and for how much time. You should take this injection for as long as it is prescribed for you.

The most common side effects of this medicine include local site reactions at the injection site, nausea, itching, diarrhea, and rash. If any of these bothers you, let your doctor know. There may be ways of reducing or preventing them. It may affect blood sugar levels, so monitor your blood sugar regularly. It is better to inform the doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain while using this medicine.

Before taking this medicine inform doctor, if you have ever had any problems with your blood circulation or have diabetes, or any liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.

Uses of Clogest Injection

Prevention of Premature Labor

Benefits of Clogest Injection

Prevention of Premature Labor
Clogest 500mg Injection is a man-made form of the female hormone called progesterone, that helps lower the risk of delivering the baby too early (premature labor), particularly in women who have had this complication in an earlier pregnancy. Progesterone is a hormone that thickens the lining of the uterus and prepares it for the growth and development of the baby. So, it helps your uterus grow during pregnancy and also prevents any contractions that can otherwise lead to miscarriage.

Side effects of Clogest Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Clogest

Injection site pain
Injection site swelling
Red spots or bumps
Rash

How to use Clogest Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Clogest Injection works

Clogest 500mg Injection is a progestin (female hormone).

All substitutes for Clogest 500mg Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Clogest 500mg Injection is used in pregnant women to help lower the risk of giving birth too early (preterm birth).
It is only given to a woman who has had a preterm delivery in the past.
It is not for use in women who are pregnant with more than one baby (twins, triplets, etc.).
It is administered only by or under the immediate supervision of your doctor. Your doctor can start giving you the injection every week between 16 and 20 weeks and continue through week 37, or until you deliver.
It may affect blood sugar levels. Monitor your blood sugar regularly.
Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain. These could be symptoms of a serious liver problem.
Inform your doctor immediately if you have pain in the chest, groin or legs, difficulty with breathing, sudden severe headache, slurred speech, sudden unexplained shortness of breath, a sudden loss of coordination, or vision changes while using this medicine.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Clogest 500mg Injection. Please consult your doctor.

Pregnancy

SAFE IF PRESCRIBED

Clogest 500mg Injection is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.

Breast feeding

SAFE IF PRESCRIBED

Available human data suggest that the drug does not pass into breast milk in clinically significant amounts and is unlikely to harm the infant.

Driving

SAFE

Clogest 500mg Injection does not usually affect your ability to drive.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Clogest 500mg Injection in patients with kidney disease. Please consult your doctor.
This medicine contains progesterone which can cause fluid retention in patients with underlying kidney disease.

Liver

UNSAFE

Clogest 500mg Injection is unsafe to use in patients with liver disease and should be avoided.

Interaction with drugs

Taking Clogest with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Tamoxifen (Oral Route)

Do not consume Tamoxifen with Hydroxyprogesterone if you have or had breast cancer. If essential, consult your doctor. Hydroxyprogesterone may reduce the efficacy of Tamoxifen.

Severe

Letrozole (Oral Route)

Do not consume Letrozole with Hydroxyprogesterone if you have or had breast cancer. If essential, consult your doctor.

Severe

Anastrozole (Oral Route)

Do not consume Anastrozole with Hydroxyprogesterone if you have or had breast cancer. If essential, consult your doctor. Hydroxyprogesterone may reduce the efficacy of Anastrozole.

Severe

Raloxifene (Oral Route)

Do not consume Raloxifene with Hydroxyprogesterone. If concurrent use is essential, please consult your doctor. Hydroxyprogesterone may reduce the efficacy of Raloxifene.

Severe

Darunavir (Oral Route)

It is recommended to use barrier methods (like condoms), IUDs, or a depot for contraception. Your doctor may monitor your treatment closely and adjust the doses as per the observations. Use barrier methods (like condoms) for contraception to reduce the risk of HIV infection.

Frequently asked questions

What is Clogest 500mg Injection? What is it used for?

Clogest 500mg Injection is a type of female sex hormone called progesterone. It helps to lower the risk of preterm delivery (early birth) in a pregnant woman, who had delivered a preterm baby in the past.

How and in what dose should I use Clogest 500mg Injection?

Clogest 500mg Injection is given as an injection, by a doctor or trained nurse. The dose will be decided by your doctor, depending on your exact medical condition.

What if I miss a dose of Clogest 500mg Injection?

Ideally, you should try not to miss any dose. However, if you miss a dose consult with your doctor as soon as you remember.

Who should not receive Clogest 500mg Injection?

Clogest 500mg Injection should not be used if you have: -blood clots or other blood clotting problems now or in the past -high blood pressure that is not controlled -liver problems, including liver tumors -breast cancer or other hormone-sensitive cancers now or in the past -unusual vaginal bleeding not related to your current pregnancy -yellowing of your skin due to liver problems during your pregnancy.

Fact Box

Chemical Class

Gluco/mineralocorticoids, progestogin derivative

Habit Forming

Therapeutic Class

GYNAECOLOGICAL

Action Class

Progestins (First generation)

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 671-72.
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 03 Apr. 2019] (online) Available from:
Hydroxyprogesterone Caproate Injection [Package Insert]. Ranipur, Uttarakhand: Akums Drugs & Pharmaceuticals Ltd. [Accessed 05 Jul. 2023]. (online) Available from:
Hydroxyprogesterone Caproate Injection [Prescribing Information]. Waltham, MA: AMAG Pharmaceuticals, Inc.; 2022. [Accessed 05 Jul. 2023]. (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Mediclove Biotech Pvt Ltd
Address: Dss-110,First Floor,Mdc Sec-5 Panchkula, Chandigarh.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Clogest 500mg Injection

Save more with additional offers

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Clogest Injection

Benefits of Clogest Injection

Side effects of Clogest Injection

How to use Clogest Injection

How Clogest Injection works

All substitutes for Clogest 500mg Injection

ANin 500mg Injection

Maintane 500 Injection

Uniprogestin 500mg Injection

Hydroport 500mg Injection

Rogee 500mg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Tamoxifen (Oral Route)

Letrozole (Oral Route)

Anastrozole (Oral Route)

Raloxifene (Oral Route)

Darunavir (Oral Route)

Frequently asked questions

What is Clogest 500mg Injection? What is it used for?

How and in what dose should I use Clogest 500mg Injection?

What if I miss a dose of Clogest 500mg Injection?

Who should not receive Clogest 500mg Injection?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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