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PhD (Pharmacology), PGDPRA
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MD Pharmacology, MBBS
Last updated
17 Dec 2024 | 01:00 AM (IST)

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Combiwave SF 25mcg/125mcg Inhaler


Product introduction

Combiwave SF 25mcg/125mcg Inhaler is a combination of two medicines that opens the airways and makes it easier to breathe. It is used in the treatment of asthma (wheezing and shortness of breath) and chronic obstructive pulmonary disorder (a lung disorder in which the flow of air to the lungs is blocked).

Your doctor will tell you how often you need to use your inhaler. The effect of this medicine may be noticeable after a few days but will only reach its maximum after a few weeks. This medicine must be used regularly to be effective, so go on taking it even if you don't have any symptoms. That means it’s doing its job. If you stop taking it your asthma and chronic obstructive pulmonary disorder (COPD) may get worse. It should not be used to relieve sudden asthma attacks. If an asthma attack occurs, use your quick-relief inhaler (reliever). To get the benefit from this medicine you need to make sure you get your inhaler technique right, otherwise, it does not work as well.

The most common side effects are nausea, vomiting, respiratory tract infection, fungal infections in the mouth, headache, hoarseness of voice, sore throat, cough, musculoskeletal (bone, muscle, or joint) pain, and increased heart rate. If you get there, do not stop taking it but do talk to your doctor. You can help prevent some of these symptoms by rinsing your mouth and throat with water or brushing your teeth after using your inhaler. There are other, rarer side effects that can be serious. Talk to your doctor if you're worried about them. In general, you should be trying to avoid situations that make your asthma worse (your triggers) and try not to smoke.

Ask your doctor whether it’s safe to take this medicine if you're pregnant or breastfeeding. Before taking it, you should tell your doctor if you have any kidney or liver diseases so that your doctor can prescribe a suitable dose for you.


Benefits of Combiwave SF Inhaler

In Treatment of Chronic obstructive pulmonary disease (COPD)

Combiwave SF 25mcg/125mcg Inhaler helps the airways in your lungs stay open. It relaxes the muscles of these airways. This makes it easier for air to get in and out. It will relieve symptoms such as tightness in your chest, shortness of breath, wheezing and coughing and help you carry out your daily activities more easily. This medicine is safe and effective. It usually starts to work within a few minutes and the effects can last up to several hours. Do not stop using it unless you are advised to by your doctor.

In Treatment of Asthma

Combiwave SF 25mcg/125mcg Inhaler can help prevent the onset of an asthma attack if it is taken before exercise or exposure to some “triggers”. These may include house dust, pollen, pets and cigarette smoke. This medicine will allow you to exercise more freely without worrying about getting symptoms such as wheezing, coughing and shortness of breath. It allows you to live your life more freely without worrying so much about things that set off your symptoms.

Side effects of Combiwave SF Inhaler

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Combiwave SF

  • Cough
  • Upper respiratory tract infection
  • Nasopharyngitis (inflammation of the throat and nasal passages)
  • Sinus inflammation
  • Stomach discomfort
  • Fungal infection of oropharynx
  • Voice change
  • Headache
  • Aggressive behavior
  • Dryness in mouth

How to use Combiwave SF Inhaler

Check the label for directions before use. Shake the inhaler. While you are breathing in from mouth, press down on the inhaler one time to release the medication and hold your breath for 10 seconds. Repeat until you have inhaled the number of puffs as suggested by the doctor.Afterwards, rinse your mouth thoroughly with water and spit it out.

How Combiwave SF Inhaler works

Combiwave SF 25mcg/125mcg Inhaler is a combination of two medicines: Salmeterol and Fluticasone Propionate. Salmeterol is a long-acting bronchodilator which works by relaxing the muscles in the airways and widens the airways. Fluticasone Propionate is a steroid. It works by stopping the release of certain chemical messengers that cause inflammation (swelling) of the airways. Together, they make breathing easier.

Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Combiwave SF 25mcg/125mcg Inhaler. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Combiwave SF 25mcg/125mcg Inhaler may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Combiwave SF 25mcg/125mcg Inhaler during breastfeeding is not available. Please consult your doctor.
Driving
No interaction found/established
Kidney
No interaction found/established
Liver
No interaction found/established

What if you forget to take Combiwave SF Inhaler?

If you miss a dose of Combiwave SF 25mcg/125mcg Inhaler, use it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Combiwave SF 25mcg/125mcg Inhaler
₹268/Inhaler
₹659.49/inhaler
121% costlier
Combitide 125 Inhaler
Sun Pharmaceutical Industries Ltd
₹652/inhaler
119% costlier
ForAir 125 CFC free Inhaler
Zydus Healthcare Limited
₹636.8/inhaler
114% costlier
Flutrol 25mcg/125mcg Inhaler
Macleods Pharmaceuticals Pvt Ltd
₹558.5/inhaler
87% costlier
Combitide Starhaler 25mcg/125mcg Inhaler
Sun Pharmaceutical Industries Ltd
₹570/inhaler
91% costlier

Quick tips

  • This medicine is for inhalation only. The tablet should not be swallowed.
  • It should be taken at the same time each day.
  • It does not work right away and should not be used to relieve sudden breathing problems. Use your rescue inhaler to control sudden difficulty in breathing. 
  • Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.
  • Gargle with warm water after each inhalation to avoid any fungal infections in your mouth and throat.
  • Take the first dose of this medicine under medical supervision as it may cause wheezing or tightening of the airways (bronchospasm) immediately after using.
  • Your doctor may regularly monitor your  blood potassium level as low oxygen level in the blood (hypoxia) and medicines such as Combiwave SF 25mcg/125mcg Inhaler can lower blood potassium level.
  • Only miniscule amounts of Combiwave SF 25mcg/125mcg Inhaler may get absorbed into the bloodstream after inhalation. Hence, serious side effects are unlikely.

Fact Box

Habit Forming
No
Therapeutic Class
RESPIRATORY

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FAQs

What is Combiwave SF 25mcg/125mcg Inhaler?

Combiwave SF 25mcg/125mcg Inhaler is an inhalation medication that helps in reducing symptoms associated with obstructive airway diseases like asthma and chronic obstructive pulmonary disease (COPD).

How does Combiwave SF 25mcg/125mcg Inhaler work?

Combiwave SF 25mcg/125mcg Inhaler contains salmeterol, a long-acting beta-2-adrenergic agonist and fluticasone, a corticosteroid. Salmeterol relaxes bronchial smooth muscles causing bronchodilation and fluticasone reduces inflammation.

Is Combiwave SF 25mcg/125mcg Inhaler a controller or a reliever medication?

Combiwave SF 25mcg/125mcg Inhaler is a controller medication to be used on a regular basis as prescribed by the doctor. It does not help to relive the sudden worsening of respiratory symptoms.

Does Combiwave SF 25mcg/125mcg Inhaler contain steroids?

Yes, it contains steroids that are effective in improving breathing difficulty due to COPD and asthma. Inhaled corticosteroids have a lower side effect profile as compared to steroid injections and tablets.

Does Combiwave SF 25mcg/125mcg Inhaler increase heart rate?

Some individuals taking Combiwave SF 25mcg/125mcg Inhaler may experience an increase in heart rate. If this occurs, one should contact his/her doctor immediately.

What are the side effects of Combiwave SF 25mcg/125mcg Inhaler?

The most common side effects of Combiwave SF 25mcg/125mcg Inhaler are upper respiratory infection, headache, throat irritation, hoarseness and voice changes, dizziness, nausea, and vomiting.

Is Combiwave SF 25mcg/125mcg Inhaler addictive?

Combiwave SF 25mcg/125mcg Inhaler is not at all addictive. It is a very effective and useful medicine for people suffering from breathing difficulties due to asthma and COPD.

Will Combiwave SF 25mcg/125mcg Inhaler be more effective if taken more frequently?

No, you should not take Combiwave SF 25mcg/125mcg Inhaler more frequently than recommended by your doctor. It will increase the risk of side effects rather than providing additional therapeutic benefits. However, if you feel the symptoms are not relieved by the given doses, consult the doctor for reevaluation.

What happens if I miss the dose of Combiwave SF 25mcg/125mcg Inhaler?

The missed dose can be taken as soon as possible. If it is time for the next dose, take the scheduled dosing and skip the missed dose.

Is there a particular breathing technique to be followed while using Combiwave SF 25mcg/125mcg Inhaler?

Combiwave SF 25mcg/125mcg Inhaler is a breath actuated inhaler (BAI), hence it is very easy to use. It overcomes the issue of patient coordination of actuation with inhalation. Refer to its leaflet or speak to your doctor to understand how to use the inhaler.

Can I use Combiwave SF 25mcg/125mcg Inhaler if I am diabetic?

Combiwave SF 25mcg/125mcg Inhaler may cause an increase in blood sugar levels, hence the blood sugar levels should be cautiously monitored. Consult your doctor for further information.

What precautions should one take while using Combiwave SF 25mcg/125mcg Inhaler?

Always use the Combiwave SF 25mcg/125mcg Inhaler in the right way. If any worsening of symptoms or side effects occurs, inform your doctor about it. Rinse your mouth with water after using the inhaler every time. Maintain good oral hygiene.

What are the instructions for storage of Combiwave SF 25mcg/125mcg Inhaler?

Combiwave SF 25mcg/125mcg Inhaler should be stored at room temperature, away from heat and direct light. It should be kept away from the reach of children and pets.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Mayo Clinic. Fluticasone And Salmeterol (Inhalation Route). [Accessed 18 Apr. 2019] (online) Available from:External Link
  2. MedlinePlus. Fluticasone and Salmeterol Oral Inhalation. [Accessed 18 Apr. 2019] (online) Available from:External Link
  3. Fluticasone propionate/formoterol fumarate dihydrate. Cambridge, UK: Bard Pharmaceuticals Limited; 2018. [Accessed 24 Apr. 2019] (online) Available from:External Link
  4. Fluticasone propionate and salmeterol [Prescribing Information]. Parsippany, NJ: Teva Pharmaceuticals USA, Inc.; 2022. [Accessed 05 Oct. 2023]. (online) Available from: External Link

Marketer details

Name: Glenmark Pharmaceuticals Ltd
Address: Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.
Country of origin: India

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