Dobonis 250mg Injection

Written By Dr. Lipika Khurana, PGDHHM, BDS

Reviewed By Dr. Mekhala Chandra, MD, MBBS

Last updated on 31 Mar 2026 | 02:31 PM (IST)

Dobonis 250mg Injection is a medicine used for short-term treatment of cardiac decompensation (low blood pressure due to poorly functioning heart) due to disease like heart failure, cardiogenic shock, or heart attack. It increases the blood pressure by increasing the pumping capacity of the heart.

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General Information

Contains

Dobutamine (250mg/5ml)

Marketer

Neiss Labs Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Dobonis 250mg Injection is also used while performing stress echocardiography evaluation of the heart. It is administered under the supervision of a doctor as it requires continuous blood pressure monitoring. The dose has to be individually adjusted as per the patient's response to therapy. You should continue all your other medicines that are advised by the doctor for your long-term treatment even after this injection. Your doctor may advise for regular monitoring of blood pressure.

It may cause side effects like high blood pressure and insomnia (difficulty in sleeping). You must inform the doctor if you are suffering from any liver or kidney disease. Also, let your doctor know about all the other medications that you are using regularly.

Uses of Dobonis Injection

Benefits of Dobonis Injection

Low blood pressure
Dobonis 250mg Injection is used to normalise decreased blood pressure (hypotension) which may occur all of a sudden during an operation, severe infection (sepsis) or due to an emergency condition (cardiac arrest). This medicine helps to bring back the blood pressure within normal range and therefore prevents any sudden fall or even serious complications that might have otherwise followed due to low blood pressure.

Side effects of Dobonis Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Dobonis

High blood pressure
Insomnia (difficulty in sleeping)

How to use Dobonis Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Dobonis Injection works

Dobonis 250mg Injection is a sympathomimetic agonist. It works by activating the receptors in the heart. This makes the heart pump blood with more strength and force and increases its pumping capacity in conditions such as heart failure.

Quick tips

It is given into the vein as a drip by a healthcare professional.
Your doctor may perform regular blood tests to monitor the level of sodium and potassium in the blood.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
It is given into the vein as a drip by a healthcare professional.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Dobonis 250mg Injection. Please consult your doctor.

Pregnancy

SAFE IF PRESCRIBED

Dobonis 250mg Injection is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.

Breast feeding

CAUTION

Dobonis 250mg Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

CONSULT YOUR DOCTOR

It is not known whether Dobonis 250mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Dobonis 250mg Injection in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Dobonis 250mg Injection in patients with liver disease.

Interaction with drugs

Taking Dobonis with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Metoprolol Succinate (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Metoprolol Succinate may reduce efficacy of Dobutamine.

Severe

Nebivolol (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Nebivolol may reduce efficacy of Dobutamine.

Severe

Labetalol (Injection Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Labetalol may reduce efficacy of Dobutamine.

Severe

Carvedilol (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Carvedilol may reduce efficacy of Dobutamine.

Severe

Atenolol (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Atenolol may reduce efficacy of Dobutamine.

Frequently asked questions

What is Dobonis 250mg Injection used for?

Dobonis 250mg Injection is a drug given through a vein to help the heart pump more effectively when it is not contracting well. It is usually used for short-term support in adults with weakened heart function due to heart disease or after heart surgery.

Who should not receive Dobonis 250mg Injection?

Individuals should not receive Dobonis 250mg Injection if they have a heart condition called idiopathic hypertrophic subaortic stenosis (a heart condition characterized by thickening of the heart muscle, particularly in the left ventricle, which can obstruct blood flow out of the heart) , or if they are allergic to dobutamine or any ingredient in the drug.

Can Dobonis 250mg Injection increase heart rate or blood pressure?

Yes, Dobonis 250mg Injection can sometimes cause a significant rise in heart rate or blood pressure, especially in people with high blood pressure. Doctors will closely monitor your heart rate and blood pressure during treatment to adjust the dose if needed.

Is Dobonis 250mg Injection safe for people with irregular heartbeats?

If you have atrial fibrillation or other irregular heart rhythms, Dobonis 250mg Injection may speed up your heart rate. In such cases, your doctor may modify the treatment regimen before starting Dobonis 250mg Injection.

What are the serious side effects of Dobonis 250mg Injection?

The serious side effects of Dobonis 250mg Injection include severe chest pain, rapid or irregular heartbeat, sudden drop in blood pressure, difficulty breathing, or signs of an allergic reaction such as rash, swelling, or wheezing. Seek immediate medical attention if you experience any of these symptoms.

Can Dobonis 250mg Injection cause low potassium levels?

Dobonis 250mg Injection may cause a mild drop in blood potassium levels. Your doctor may monitor your potassium during treatment, especially if you are at risk for low potassium.

Can Dobonis 250mg Injection be used after a heart attack?

Dobonis 250mg Injection is not routinely recommended immediately after a heart attack because it might increase the size of the damaged area in the heart. Your doctor will decide if the benefits outweigh the risks in your case.

How quickly does Dobonis 250mg Injection start working?

Dobonis 250mg Injection usually begins working within 1 to 2 minutes after starting the infusion , and its peak effect may be seen within about 10 minutes.

Fact Box

Chemical Class

Catecholamine derivative

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Beta-Adrenergic Inotropes

References

Maron BA, Rocco TP. Pharmacotherapy of Congestive Heart Failure. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 804-805.
Katzung BG, Parmley WW. Drugs Used in Heart Failure. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 216-217.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 421.
Teerlink JR, Sliwa K, Opie LH. Heart Failure. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. pp. 177-81.
Dobutamine. Hameln, Germany: Siegfried Hameln GmbH; 2018. [Accessed 15 Mar. 2019] (online) Available from:
Dobutamine. Lake Forest, Illinois: Hospira, Inc.; 2016. [Accessed 15 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Dobutamine. [Updated 2018 Dec 3]. [Accessed 19 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). Dobutamine. [Accessed 15 Mar. 2019] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Neiss Labs Pvt Ltd
Address: 802, DLH Park, S.V. Road, Goregaon (W), Mumbai-400064, INDIA

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Dobonis 250mg Injection

Save more with additional offers

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Dobonis Injection

Benefits of Dobonis Injection

Side effects of Dobonis Injection

How to use Dobonis Injection

How Dobonis Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Metoprolol Succinate (Oral Route)

Nebivolol (Oral Route)

Labetalol (Injection Route)

Carvedilol (Oral Route)

Atenolol (Oral Route)

Frequently asked questions

What is Dobonis 250mg Injection used for?

Who should not receive Dobonis 250mg Injection?

Can Dobonis 250mg Injection increase heart rate or blood pressure?

Is Dobonis 250mg Injection safe for people with irregular heartbeats?

What are the serious side effects of Dobonis 250mg Injection?

Can Dobonis 250mg Injection cause low potassium levels?

Can Dobonis 250mg Injection be used after a heart attack?

How quickly does Dobonis 250mg Injection start working?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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