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Last updated
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Espazine Plus 5mg/2mg Tablet


Product introduction

Espazine Plus 5mg/2mg Tablet is a combination medicine used in the treatment of schizophrenia (a mental disorder in which a person develops unreal thoughts and behavior). It alters the thoughts and elevates the mood, improving the person’s ability to think, feel and behave.

Espazine Plus 5mg/2mg Tablet also helps by improving muscle control and reducing the stiffness of the muscle. It may be taken with or without food, preferably at the same time each day. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember it. Do not skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to your doctor as it may worsen your symptoms.

Some common side effects of this medicine include nausea, constipation, dryness in mouth, sedation, abnormal heart rhythm, urinary retention, blurred vision, and nervousness. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, rise slowly if you have been sitting or lying down. It may also cause dizziness and sleepiness, do not drive or do anything that requires mental focus until you know how this medicine affects you.

Before taking it, inform your doctor if you are suffering from thyroid or kidney problems, epilepsy, Parkinson’s disease, glaucoma, or any heart problems. You should not take this medicine if you are under the influence of alcohol or any sleep-inducing, cough, and/ or allergy medication. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly.

Uses of Espazine Plus Tablet

Benefits of Espazine Plus Tablet

In Schizophrenia

Schizophrenia is a mental disorder in which a person’s thinking ability, feelings and behavior become abnormal. Espazine Plus 5mg/2mg Tablet helps restore the chemical imbalances in the brain that are responsible for such changes. It improves thoughts, behavior and enhances the quality of life.

Side effects of Espazine Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Espazine Plus

  • Nausea
  • Constipation
  • Dryness in mouth
  • Sedation
  • Weight gain
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Urinary retention
  • Increased prolactin level in blood
  • Dizziness
  • Blurred vision
  • Nervousness

How to use Espazine Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Espazine Plus 5mg/2mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Espazine Plus Tablet works

Espazine Plus 5mg/2mg Tablet is a combination of two medicines: Trifluoperazine and Trihexyphenidyl. Trifluoperazine is a typical antipsychotic. It works by blocking the action of a chemical messenger (dopamine) in the brain that affects thoughts and mood. However, it may cause side effects such as involuntary movements (shaking of hands, muscle spasms). Trihexyphenidyl is added to treat and prevent these side effects.

Safety advice

Alcohol
UNSAFE
Espazine Plus 5mg/2mg Tablet may cause excessive drowsiness with alcohol.
Pregnancy
CONSULT YOUR DOCTOR
Espazine Plus 5mg/2mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Espazine Plus 5mg/2mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Espazine Plus 5mg/2mg Tablet may cause side effects which could affect your ability to drive.
Espazine Plus 5mg/2mg Tablet can cause blurring of vision, dizziness, mild nausea, and mental confusion in some cases. This may affect your ability to drive.
Kidney
CONSULT YOUR DOCTOR
There is limited information available on the use of Espazine Plus 5mg/2mg Tablet in patients with kidney disease. Please consult your doctor.
Patients with kidney disease should be closely monitored by a doctor while taking this medicine.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Espazine Plus 5mg/2mg Tablet in patients with liver disease. Please consult your doctor.

What if you forget to take Espazine Plus Tablet?

If you miss a dose of Espazine Plus 5mg/2mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Espazine Plus 5mg/2mg Tablet
₹2.68/Tablet
Parkin-Plus Tablet
Micro Labs Ltd
₹3.87/tablet
44% costlier
Trinicalm Plus Tablet
Torrent Pharmaceuticals Ltd
₹2.8/tablet
4% costlier
Neocalm Plus Tablet
Intas Pharmaceuticals Ltd
₹1.5/tablet
44% cheaper
Trazine-S Tablet
Sun Pharmaceutical Industries Ltd
₹2.5/tablet
7% cheaper
Parkin-Plus Tablet
Micro Labs Ltd
₹3.85/tablet
44% costlier

Quick tips

  • Espazine Plus 5mg/2mg Tablet is a combination medicine that helps treat schizophrenia.
  • Be cautious while driving or doing anything that requires concentration as Espazine Plus 5mg/2mg Tablet can cause dizziness and sleepiness.
  • It can cause dry mouth. Maintain good oral hygiene,drink water, chew sugarless gum, or suck on hard candy for the dry mouth.
  • It can make you more sensitive to changes in temperature. Drink plenty of liquids and dress appropriately.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • Inform your doctor if you have glaucoma or trouble passing urine.
  • Do not stop taking Espazine Plus 5mg/2mg Tablet without talking to your doctor first as it may cause worsening of symptoms.

Fact Box

Habit Forming
No
Therapeutic Class
NEURO CNS

Patient concerns

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My father is taking espazine plus (BD) along with Kemadrin 5 mg (BD) but right now espazine plus is available at most of the market. Can i purchase any substitute of that medicine? If yes, then which one? Sorry Espazine plus is not available at any stores!
Dr. Jyoti Kapoor Madan
Psychiatry
Trifluperazine and trihexyphenidyl are available at pharmacies. Please take proper prescription for medicines, just because someone was prescribed medicines once, doesn't mean one should continue it without regular follow up.
She had a psyco problem 25 yrs before since then she take Espazine plus daily 001 dose, without that she fells dis comfort. Will it give side effect, if so any eqealant or new drug please
Dr. Venkatraju Kalidindi
Psychiatry
Dear 1mg user, medicines gives quick relief and has side effects too so consult your doctor and see how to reduce dose and control totally, later you can take counselling that really helps you.
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User feedback


FAQs

How long does Espazine Plus 5mg/2mg Tablet take to work?

Everybody responds to the treatment differently. In general, it can take several weeks to feel the full benefits of Espazine Plus 5mg/2mg Tablet, although some people may start to feel better sooner. It is important to give this drug the time to work.

Can I stop taking Espazine Plus 5mg/2mg Tablet if I feel well?

No, you should continue taking Espazine Plus 5mg/2mg Tablet even if you feel well. If you stop Espazine Plus 5mg/2mg Tablet suddenly, serious withdrawal problems may occur. Your doctor will probably decrease your dose gradually before asking you to stop Espazine Plus 5mg/2mg Tablet.

Can the use of Espazine Plus 5mg/2mg Tablet cause sleepiness?

Yes, Espazine Plus 5mg/2mg Tablet can make you feel sleepy. Avoid driving, operating machinery, working at heights or participating in potentially dangerous activities till you know how this medicine affects you.

Can the use of Espazine Plus 5mg/2mg Tablet cause dry mouth?

Yes, the use of Espazine Plus 5mg/2mg Tablet can cause dry mouth. If you experience dry mouth, drink plenty of water. Take regular sips during the day and keep some water by your bed at night. You may use lip balm if your lips are also dry. Try to avoid foods that are acidic (like lemons), spicy and salty.

What are the instructions for the storage and disposal of Espazine Plus 5mg/2mg Tablet?

Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Drugs.com. Trifluoperazine. [Accessed 23 Apr. 2019] (online) Available from:External Link
  2. Trihexyphnidyl. Huddersfield, West Yorkshire: Genus Pharmaceuticals; 2011 [revised 18 Dec. 2018]. [Accessed 23 Apr. 2019] (online) Available from:External Link
  3. Trifluoperazine. Leeds, Yorkshire: Rosemont Pharmaceuticals Limited; 2008 [revised 27 Nov. 2018]. [Accessed 23 Apr. 2019] (online) Available from:External Link
  4. Drugs.com. Trihexyphenidyl. [Accessed 23 Apr. 2019] (online) Available from:External Link

Marketer details

Name: Glaxo SmithKline Pharmaceuticals Ltd
Address: Dr. Annie Besant Road, Mumbai - 400 030
Country of origin: India

DISCONTINUED
We do not facilitate sale of this product at present

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