Graftin 50mg Tablet
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Product introduction
Graftin 50mg Tablet is used to prevent the body from rejecting a new organ after a liver, kidney, heart transplant, or bone marrow transplantation. It weakens the immune system so that your body does not attack the new organ. It is also used to treat nephrotic syndrome, severe rheumatoid arthritis, and psoriasis.
The amount of Graftin 50mg Tablet you take depends on your weight, medical condition, and what you are being treated for. Your doctor will plan the correct dose for you. Do not change the dose without talking to your doctor. It can be taken with or without food. It is better to take it, in the same way, and at the same time every day to get the maximum benefit. Keep taking it for as long as you have been told to, even if you feel well. Stopping treatment may increase the risk of your transplanted organ being rejected.
The most common side effects of this medicine include headache, unusual growth of facial or body hair, high blood pressure, diarrhea, gingival hyperplasia, and tremors. Because it lowers your immune system, you may also catch more infections than usual. Tell your doctor straight away if you develop an infection. For the same reason, you may be more at risk of developing some cancers, particularly of the skin. You should limit your exposure to sunlight.
Before taking this medicine you should tell your doctor if you have liver or kidney problems, high blood pressure, gout (increased uric acid levels in the blood), or epilepsy. Also, tell your doctor about all other medicines you are taking as they may affect the working of the medicine. This medicine should only be used in pregnancy if it is clearly needed. However, it is not recommended while breastfeeding. You will have frequent medical tests while taking this medicine to check your blood pressure, liver and kidney function, and mineral levels. The results of tests may lead to changes in your dose.
The amount of Graftin 50mg Tablet you take depends on your weight, medical condition, and what you are being treated for. Your doctor will plan the correct dose for you. Do not change the dose without talking to your doctor. It can be taken with or without food. It is better to take it, in the same way, and at the same time every day to get the maximum benefit. Keep taking it for as long as you have been told to, even if you feel well. Stopping treatment may increase the risk of your transplanted organ being rejected.
The most common side effects of this medicine include headache, unusual growth of facial or body hair, high blood pressure, diarrhea, gingival hyperplasia, and tremors. Because it lowers your immune system, you may also catch more infections than usual. Tell your doctor straight away if you develop an infection. For the same reason, you may be more at risk of developing some cancers, particularly of the skin. You should limit your exposure to sunlight.
Before taking this medicine you should tell your doctor if you have liver or kidney problems, high blood pressure, gout (increased uric acid levels in the blood), or epilepsy. Also, tell your doctor about all other medicines you are taking as they may affect the working of the medicine. This medicine should only be used in pregnancy if it is clearly needed. However, it is not recommended while breastfeeding. You will have frequent medical tests while taking this medicine to check your blood pressure, liver and kidney function, and mineral levels. The results of tests may lead to changes in your dose.
Uses of Graftin Tablet
- Prevention of organ rejection in transplant patients
- Treatment of Rheumatoid arthritis
- Treatment of Psoriasis
- Prevention of graft rejection following Bone marrow transplantation
- Treatment of Nephrotic syndrome
Benefits of Graftin Tablet
In Prevention of organ rejection in transplant patients
Graftin 50mg Tablet belongs to a group of medicines known as immunosuppressive agents. It lowers your immune response and reduces the chance of your body attacking the transplanted organ. Organ rejection happens when your immune system treats the new organ as an invader and attacks it. This medicine suppresses the immune system and helps your body accept the new organ as if it were your own.
In Treatment of Rheumatoid arthritis
Rheumatoid arthritis is an autoimmune condition where your body’s immune system (which usually fights bacteria and viruses) attacks your body’s own cells. Graftin 50mg Tablet stops that from happening and can relieve the symptoms of this condition such as pain, swelling, and stiffness in your joints. It can also slow down joint damage, reduce disability, and enable you to be as active for as long as possible. It can take several weeks or months to notice the effect of the medicine. You should continue taking it until your doctor says it is okay to stop using the medicine.
In Treatment of Psoriasis
Graftin 50mg Tablet can be used to treat severe psoriasis when other treatments have not worked or are not appropriate. Psoriasis happens when skin cells are replaced more quickly than usual. This medicine can improve your skin and reduce the symptoms of rash, redness, and pain. The improvement in the appearance of your skin can boost your confidence and improve your life. Psoriasis is a long-term condition. You should keep taking this medicine for as long as it is prescribed.
In Prevention of graft rejection following Bone marrow transplantation
Graftin 50mg Tablet suppresses the immune response, reducing the risk of the recipient's immune system attacking and rejecting the transplanted bone marrow. This increases the success rate of the transplant and allows for the restoration of normal blood cell production and immune function.
In Treatment of Nephrotic syndrome
Nephrotic syndrome is a kidney disorder that causes your body to pass too much protein in your urine accompanied with excessive swelling over various parts of the body such as around the eyes and in the feet and ankles. Graftin 50mg Tablet works by suppressing the immune system thereby reducing inflammation and swelling that occur in nephrotic syndrome. It reduces the protein in the urine and also helps in getting rid of the extra fluid, thereby relieving the swelling over different parts of the body. This helps to restore the normal kidney function and prevents further damage to the kidneys.
Side effects of Graftin Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Graftin
- Headache
- Nausea
- Vomiting
- Increased hair growth
- High blood pressure
- Renal dysfunction
- Loss of appetite
- Diarrhea
- Tremors
- Gingival hypertrophy (gum enlargement)
How to use Graftin Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Graftin 50mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Graftin Tablet works
Graftin 50mg Tablet is an immunosuppressant. It works by suppressing your body’s immune response to help accept a newly transplanted organ (e.g., liver, kidney, or heart). In rheumatoid arthritis, this immunosuppressive effect reduces inflammation (swelling) of joints and limits joint damage. In psoriasis, it works by reducing the activity of certain immune cells that cause overproduction of skin cells, thus improving scaling and redness.
Safety advice
Alcohol
SAFE
Consuming alcohol with Graftin 50mg Tablet does not cause any harmful side effects.
Pregnancy
CONSULT YOUR DOCTOR
Graftin 50mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
UNSAFE
Graftin 50mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
CONSULT YOUR DOCTOR
It is not known whether Graftin 50mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
CAUTION
Graftin 50mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Graftin 50mg Tablet may be needed. Please consult your doctor.
Regular monitoring of kidney function test is advised while you are taking this medicine.
Regular monitoring of kidney function test is advised while you are taking this medicine.
Liver
CAUTION
Graftin 50mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Graftin 50mg Tablet may be needed. Please consult your doctor.
Regular monitoring of kidney function test is advised while you are taking this medicine.
Regular monitoring of kidney function test is advised while you are taking this medicine.
What if you forget to take Graftin Tablet?
If you miss a dose of Graftin 50mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Graftin 50mg Tablet
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Quick tips
- Graftin 50mg Tablet is used to prevent organ rejection in transplant patients.
- It is also used to treat arthritis and immune disorders of the eyes, lungs, muscles, skin, nerves, and blood vessels.
- It may take 3 to 4 months for the medication to work. Keep taking it as prescribed.
- Your doctor may get regular blood tests done to check the levels of blood cells in your blood. Inform your doctor if you experience unexplained bruising or bleeding, sore throat, mouth ulcers, fever or general illness.
- Your doctor may monitor your kidney function regularly. Drink 8 to 10 glasses of water per day to help with your kidney function.
- Do not stop taking Graftin 50mg Tablet without talking to your doctor first.
Fact Box
Chemical Class
Cyclosporin Derivative
Habit Forming
No
Therapeutic Class
PAIN ANALGESICS
Action Class
Immunosuppressant- Calcineurin inhibitors
Interaction with drugs
Taking Graftin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Concurrent use may cause damage to muscles and kidneys. Ciclosporin may raise blood levels of Pitavastatin.
Do not consume Pitavastatin with Ciclosporin.
Concomitant use may affect heart rhythm and can be fatal. Ciclosporin may raise blood levels of Lovastatin.
Do not consume Lovastatin with Ciclosporin. If concurrent use is essenti
Ciclosporin may raise blood levels of Rosuvastatin.
Do not consume Rosuvastatin with Ciclosporin.
Concurrent use may cause damage to muscles and kidneys. Ciclosporin may raise blood levels of Simvastatin.
Do not consume Simvastatin with Ciclosporin. If concurrent use is essenti
Concomitant use may cause lethal infections.
Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) should not be used while undergoing treatment with Ciclosporin or for up to
Patient concerns
FAQs
Is Graftin 50mg Tablet a steroid?
No, Graftin 50mg Tablet is not a steroid. It belongs to a group of medicines known as immunosuppressive agents. It decreases the action of the body’s immune system.
Can Graftin 50mg Tablet cause weight gain?
Yes, Graftin 50mg Tablet may cause weight gain. However, the changes in weight are uncommon side effects of this medicine. Consult your doctor if these side effects worry you.
Does Graftin 50mg Tablet cause hair growth?
Yes, the use of Graftin 50mg Tablet may cause abnormal hair growth (hypertrichosis) as a common side effect of Graftin 50mg Tablet, though it does not affect everyone.
Does Graftin 50mg Tablet cause fatigue?
Yes, Graftin 50mg Tablet may cause fatigue as a common side effect. However, fatigue could also be due to an underlying disease. Discuss with your doctor if this side effect worries you.
Do I need to get any tests done while being treated with Graftin 50mg Tablet?
Yes, the doctor may suggest tests to check the levels of Graftin 50mg Tablet in your blood, especially if you have had a transplant. You may also be advised to get your blood pressure checked before the start of your treatment and regularly during treatment. In addition, liver and kidney function tests along with your blood lipids (fats), will be checked.
Can Graftin 50mg Tablet cause cancer?
Graftin 50mg Tablet is known to suppress the immune system. This as a result, increases your risk of developing cancers, particularly of the skin and lymphoid system. You should limit your exposure to sunlight and UV light by wearing appropriate protective clothing. Sunscreen should be applied frequently with a high protection factor.
What are the side effects of Graftin 50mg Tablet?
Graftin 50mg Tablet may cause side effects such as headache, diarrhea, heartburn, increased hair growth on the face, arms, or back, growth of extra tissue on the gums, acne, flushing, and uncontrollable shaking of a part of your body. You may also experience burning or tingling sensation in the hands, arms, feet, or legs, muscle or joint pain, cramps, pain or pressure in the face, ear problems, breast enlargement in men, depression and difficulty falling asleep or staying asleep.
How should Graftin 50mg Tablet be taken?
Take Graftin 50mg Tablet strictly as advised by your doctor. The doctor will decide and carefully adjust your dose according to your medical requirements. It is important to keep a constant amount of Graftin 50mg Tablet in the body, and hence, the medicine should be taken at the same time each day. Not only is the time of day important, but also when Graftin 50mg Tablet is taken concerning meals.
How long do I need to take Graftin 50mg Tablet?
Take Graftin 50mg Tablet for as long as the doctor has advised. The duration of treatment depends on whether you are taking it after a transplant or for the treatment of other conditions. Usually, the treatment may last for 8 weeks if you are taking it for severe rash.
What is Graftin 50mg Tablet used for?
Graftin 50mg Tablet is used in combination with other medications which are used to prevent transplant rejection (attack of the transplanted organ by the immune system of the person who received the organ) in people who have received kidney, liver and heart transplants. These combination medicines also help to treat the symptoms of rheumatoid arthritis (a disease, affecting the joints with pain and swelling) in patients whose symptoms were not relieved by methotrexate alone. It is also used to treat psoriasis (a skin disease in which red, scaly patches form on some areas of the body), and atopic dermatitis (skin allergies).
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Burkhart C, Morrell D, Goldsmith L. Dermatological Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1821.
- Wallace JL, Sharkey KA. Pharmacotherapy of Inflammatory Bowel Disease. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1358-59.
- Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 630-31.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 340-42.
- Ciclosporine. Camberley, Surrey: Novartis Pharmaceuticals UK Ltd.; 1983 [revised 24 Jul. 2015]. [A cessed 25 Jan. 2019].(online) Available from:
- Cyclosporine. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation. [Accessed 06 Apr. 2019] (online) Available from:
- Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 03 Apr. 2019] (online) Available from:
- Cyclosporine [Product Monograph]. Quebec, Canada: Novartis Pharmaceuticals Canada Inc.; 2023. [Accessed 16 Jun. 2023] (online) Available from:
Marketer details
Name: Sun Pharmaceutical Industries Ltd
Address: Plot no 107/108,Namli block , Ranipool, East Sikkim 737135
Country of origin: India
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