Letfirst Tablet
Prescription Required
Product introduction
Letfirst Tablet helps treat breast cancer in post-menopausal women. It may be used alone or with other treatments, such as surgery or radiation. It can also be used in patients with advanced breast cancer to stop the tumor from spreading to other parts of the body.
Letfirst Tablet can be taken with or without food. Take it in the dose and duration prescribed by the doctor to get the most benefit. The dose and frequency depend on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed.
The most common side effects of this medicine include hot flashes, fatigue, increased sweating, and increased level of cholesterol (hypercholesterolemia). If these bother you or appear serious, let your doctor know. Your doctor may suggest ways to prevent or reduce these.
Before taking this medicine, tell your doctor if you have ever had liver or kidney disease, or have a history of osteoporosis (thinning or wasting of bones). Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Tell your doctor if you are pregnant or breastfeeding. Your doctor may perform some blood tests to check for vitamin D level or bone density before and during treatment.
Uses of Letfirst Tablet
Benefits of Letfirst Tablet
In Treatment of Breast cancer
Letfirst Tablet relieves the symptoms of breast cancer such as breast lumps, bloody discharge from the nipple, or changes in the shape or texture of the breast. It works by altering the production of those hormones in the body that are essential for the growth and spread of breast cancer. It may also interact with other hormones or have a direct effect on cancer to stop its growth.
Side effects of Letfirst Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Letfirst
- Night sweats
- Bone pain
- Cough
- Shortness of breath
- Fatigue
- Weight gain
- Hot flushes
- Edema (swelling)
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Diaphoresis
- Bone fracture
- Hypercholesterolemia (high cholesterol)
- Joint pain
- Back pain
- Weakness
- Dizziness
- Nausea
- Osteoporosis
- Joint inflammation
How to use Letfirst Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Letfirst Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Letfirst Tablet works
Letfirst Tablet is an aromatase inhibitor. It works by decreasing the amount of estrogen (natural female hormone) produced in the body. This decrease in estrogen can slow down or stop the growth of some breast cancers that need estrogen to grow.
Safety advice
Alcohol
SAFE
Consuming alcohol with Letfirst Tablet does not cause any harmful side effects.
Pregnancy
UNSAFE
Letfirst Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding
UNSAFE
Letfirst Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
Letfirst Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
SAFE IF PRESCRIBED
Letfirst Tablet is safe to use in patients with kidney disease. No dose adjustment of Letfirst Tablet is recommended.
However, there is limited information on the use of this medicine in patients with end stage kidney disease. Please consult with your doctor.
However, there is limited information on the use of this medicine in patients with end stage kidney disease. Please consult with your doctor.
Liver
CAUTION
Letfirst Tablet should be used with caution in patients with liver disease. Dose adjustment of Letfirst Tablet may be needed. Please consult your doctor.
What if you forget to take Letfirst Tablet?
If you miss a dose of Letfirst Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.\n
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
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Quick tips
- You have been prescribed Letfirst Tablet for the treatment of breast cancer.
- It can be taken with or without food.
- Do not drive or do anything requiring concentration until you know how Letfirst Tablet affects you.
- It may cause increased sweating and hot flushes. Try to keep cool by wearing light and airy clothes.
- Your doctor may monitor your cholesterol level and bone mineral density (BMD) regularly as Letfirst Tablet can alter their levels.
- Do not take Letfirst Tablet if you are pregnant or breastfeeding
Fact Box
Chemical Class
Diphenylmethane Derivative
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Aromatase inhibitor
Patient concerns
FAQs
Why have I been prescribed Letfirst Tablet?
Letfirst Tablet is an aromatase inhibitor. It is generally prescribed to treat breast cancer in women who no longer have periods, either due to menopause or after surgery or chemotherapy.
How does Letfirst Tablet work?
Letfirst Tablet is also known as an anti-estrogen drug. It is called so because it acts by reducing the production of estrogen in your body by blocking the enzyme aromatase, which is responsible for the production of estrogen. Estrogen stimulates the production of certain types of breast cancer in your body. These cancers are called "estrogen-dependent cancers". Reducing the production of estrogen may prevent cancer from growing.
For how long should I take Letfirst Tablet?
If the breast tumor is in the advanced stage or has spread to other parts of the body, it is recommended that you continue taking Letfirst Tablet till the tumor shows progression. In cases where Letfirst Tablet is given after tamoxifen (another anti-estrogen used for breast cancer) or surgery, it should be given for 5 years or until the tumor comes back, whichever is first. It can also be given as a sequential treatment; 2 years of Letfirst Tablet followed by 3 years of tamoxifen.
If I am taking irbesartan to control my blood pressure, can I take Letfirst Tablet?
Yes, you can take irbesartan and Letfirst Tablet together. However, be careful and keep a regular check on your blood pressure since Letfirst Tablet may increase your blood pressure. Consult your doctor in case you have problems controlling your blood pressure.
Does Letfirst Tablet affect vision?
Although it is very uncommon, Letfirst Tablet may cause a cataract. So, if you experience blurred vision or eye irritation, consult your doctor immediately.
My friend who is taking Letfirst Tablet often sweats a lot. Is it because of Letfirst Tablet?
This could be a sign of hot flushes which is a very common side effect of Letfirst Tablet. It happens due to decreased estrogen levels. The frequency of hot flushes reduces once your body adjusts to Letfirst Tablet. However, in some people, the flushes and sweats may continue during the treatment and stop a few months after the treatment finishes. You can consult your doctor who will provide you a remedy if it is very bothersome.
What are the serious side effects of Letfirst Tablet?
The serious side effects do not occur in everyone and very few people experience them. The serious side effects of Letfirst Tablet include stroke, angina, heart attack, blood clotting, cataract, osteoporosis, and severe skin reactions.
Does Letfirst Tablet cause bone loss?
Letfirst Tablet may cause thinning or wasting of your bones (osteoporosis), which is due to the decrease in estrogen levels in your body. Your doctor may decide to measure your bone density (a way of monitoring for osteoporosis) before, during and after treatment.
Can I take Letfirst Tablet for induction of ovulation in anovulatory infertility?
As per the Ministry of Health and Family Welfare, Letfirst Tablet is restricted for use in induction of ovulation in anovulatory infertility.
Why have I been prescribed Letfirst Tablet?
Letfirst Tablet is an aromatase inhibitor. It is generally prescribed to treat breast cancer in women who no longer have periods, either due to menopause or after surgery or chemotherapy.
How does Letfirst Tablet work?
Letfirst Tablet is also known as an anti-estrogen drug. It is called so because it acts by reducing the production of estrogen in your body by blocking the enzyme aromatase, which is responsible for production of estrogen. Estrogen stimulates the production of certain types of breast cancer in your body. These cancers are called "estrogen-dependent cancers". Reducing the production of estrogen may prevent the cancer from growing.
For how long should I take Letfirst Tablet?
If the breast tumor is in advanced stage or has spread to other parts of the body, it is recommended that you continue taking Letfirst Tablet till the tumor shows progression. In cases where Letfirst Tablet is given after tamoxifen (another anti-estrogen used for breast cancer) or surgery, it should be given for 5 years or until tumor comes back, whichever is first. It can also be given as a sequential treatment; 2 years of Letfirst Tablet followed by 3 years of tamoxifen.
If I am taking irbesartan to control my blood pressure, can I take Letfirst Tablet?
Yes, you can take irbesartan and Letfirst Tablet together. However, be careful and keep a regular check on your blood pressure since Letfirst Tablet may increase your blood pressure. Consult your doctor in case you have problems controlling your blood pressure.
Does Letfirst Tablet affect vision?
Although it is very uncommon but Letfirst Tablet may cause cataract. So, if you experience blurred vision or eye irritation, consult your doctor immediately.
My friend who is taking Letfirst Tablet often sweats a lot. Is it because of Letfirst Tablet?
This could be a sign of hot flushes which is a very common side effect of Letfirst Tablet. It happens due to decreased estrogen levels. The frequency of hot flushes reduces once your body adjusts to Letfirst Tablet. However, in some people the flushes and sweats may continue during the treatment and stop a few months after the treatment finishes. You can consult your doctor who will provide you a remedy if it is very bothersome.
What are the serious side effects of Letfirst Tablet?
The serious side effects do not occur in everyone and very few people experience them. The serious side effects of Letfirst Tablet include stroke, angina, heart attack, blood clotting, cataract, osteoporosis and severe skin reactions.
Does Letfirst Tablet cause bone loss?
Letfirst Tablet may cause thinning or wasting of your bones (osteoporosis), which is due to the decrease in estrogen levels in your body. Your doctor may decide to measure your bone density (a way of monitoring for osteoporosis) before, during and after treatment.
Can I take Letfirst Tablet for induction of ovulation in anovulatory infertility?
As per the Ministry of Health and Family Welfare, Letfirst Tablet is restricted for use in induction of ovulation in anovulatory infertility.
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Moy B, Lee RJ, Smith M. Natural Products in Cancer Chemotherapy: Hormones and Related Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. p. 1762.
- Masters SB. Hypothalmic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 718.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 786-87.
- Letrozole. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 1997 [revised Jan. 2014]. [Accessed 03 Apr. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 04 Apr. 2019] (online) Available from:
- National Health Service. Letrozole. [Last Reviewed: 21 Jul 2020]. [Accessed 08 Jul. 2023]. (online) Available from:
- Letrozole [Package Insert]. Mumbai, India: HOPE Lifecare. [Accessed 08 Jul. 2023]. (online) Available from:
- Letrozole [Prescribing Information]. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2020. [Accessed 08 Jul. 2023]. (online) Available from:
Marketer details
Name: UFirst Pharmaceutical Private Limited
Address: 903, Madurdah, Hossainpur. Beside Kabi Sukanta Metro Station. Kolkata
Country of origin: India
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