Macdanib 150mg Capsule is used in the treatment of idiopathic pulmonary fibrosis and non-small cell lung cancer. It works by targeting certain pathways involved in the growth and progression of these diseases and helps to stop or slow the spread of cancer cells.

Macdanib 150mg Capsule should be taken with food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Diarrhea is a very common side effect of this medicine. You are advised to drink plenty of fluids and inform your doctor if it does not go away. Other common side effects include nausea, abdominal pain, vomiting, abnormal liver function tests, loss of appetite, headache, weight loss, and high blood pressure. Your doctor might ask you for some blood tests to monitor liver functioning.

Before taking it, tell your doctor if have a bleeding problem, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Macdanib Capsule

Benefits of Macdanib Capsule

In Treatment of Idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis is a lung disease caused by lung tissue becoming thick and stiff and eventually forming scar tissue within the lungs. The scarring, or fibrosis, seems to result from a cycle of damage and healing that occurs in the lungs. These changes are irreversible and the affected person may experience shortness of breath or dry cough as initial symptoms. Macdanib 150mg Capsule kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. You may experience some bothersome side effects. Discuss with your doctor if you have any doubts.

In Treatment of Non-small cell lung cancer

Non-small cell lung cancer is one of the major kinds of lung cancer and it affects both smokers as well as non-smokers. Macdanib 150mg Capsule helps treat non-small cell lung cancer and may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

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Side effects of Macdanib Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Macdanib

Diarrhea
Nausea
Abdominal pain
Vomiting
Abnormal liver function tests
Loss of appetite
Headache
Weight loss
High blood pressure

How to use Macdanib Capsule

Take this medicine in the dose and duration as advised by your doctor. Macdanib 150mg Capsule is to be taken with food.

How Macdanib Capsule works

Macdanib 150mg Capsule is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. It also blocks pathways in the body that result in fibrosis, which is the thickening or scarring of the tissue. This helps to stop or slow the spread of cancer cells.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Macdanib 150mg Capsule. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Macdanib 150mg Capsule is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Macdanib 150mg Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Macdanib 150mg Capsule may cause side effects which could affect your ability to drive.
You may feel sick after taking this medicine and this could affect your driving.

Kidney

CAUTION

Macdanib 150mg Capsule should be used with caution in patients with severe kidney disease. Dose adjustment of Macdanib 150mg Capsule may be needed. Please consult your doctor.
There is limited information available on the use of Macdanib 150mg Capsule in these patients.

Liver

CAUTION

Macdanib 150mg Capsule should be used with caution in patients with liver disease. Dose adjustment of Macdanib 150mg Capsule may be needed. Please consult your doctor.
Use of Macdanib 150mg Capsule is not recommended in patients with moderate to severe liver disease.

What if you forget to take Macdanib Capsule?

If you miss a dose of Macdanib 150mg Capsule, skip it and continue with your normal schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Macdanib 150mg Capsule

₹78.5/Capsule

Mantedanib Capsule 150mg

Mankind Pharma Ltd

₹88.1/capsule

12% costlier

Nintabid 150mg Capsule

J B Chemicals and Pharmaceuticals Ltd

₹106.8/capsule

36% costlier

Fibronib 150 Capsule

Chemo Healthcare Pvt Ltd

₹87.3/capsule

11% costlier

Bronchonib 150 Soft Gelatin Capsule

BDR Pharmaceuticals Internationals Pvt

₹84.6/capsule

8% costlier

Prutis 150mg Capsule

Hetero Drugs Ltd

₹87.3/capsule

11% costlier

Fact Box

Chemical Class

Indolecarboxylic Acids

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Tyrosine kinase inhibitors

Interaction with drugs

Taking Macdanib with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Rifampicin (Oral Route) Severe

Rifampicin may reduce blood levels of Nintedanib. Do not consume Nintedanib with Rifampicin.

Rifampicin (Injection Route) Severe

Rifampicin may reduce blood levels of Nintedanib. Do not consume Nintedanib with Rifampicin.

Phenytoin (Oral Route) Severe

Phenytoin may reduce blood levels of Nintedanib. Do not consume Nintedanib with Phenytoin.

Phenytoin (Injection Route) Severe

Phenytoin may reduce blood levels of Nintedanib. Do not consume Nintedanib with Phenytoin.

Carbamazepine (Oral Route) Severe

Carbamazepine may reduce blood levels of Nintedanib. Do not consume Nintedanib with Carbamazepine.

View all drug interactions

Patient concerns

Can idiopathic pulmonary fibrosis be cured?

Dr. Manju Singh

Homeopathy

I would like to suggest you that please consult with your nearest homeopathy doctor because your case require detail case taking.

What is the purpose of Chemotherepy given at the time of radiotherapy in ca lung small cell carcinoma

Dr. Vijay Sharnangat

Medical Oncology and Hematology

This is given to enhance the therapeutic effect of radiation therapy which is curative for small cell lung cancer.

My mother is suffering from Interstitial Lungs disease since 4 yrs.She is on home oxygen since 3 yrs from then for atleast 14-16 hrs.Currently she is getting treatment from AIIMS,New Delhi and the medecines given are as under:- Pirfenidone (600mg-Thrice a day) Sildenafil (25mg-Thrice a day) Tab Uprise D3 for calcium-60000 units (Once a month) Tab DDR60-Once a day. The treatment has been for exactly 1 yrs and 3 months from now but the disease is still on a progressive mode.She is not improving.My family is very worried. Please help out with proper treatment for this disease.This disease is also known as Idiopathic Pulmonary Fibrosis (IPF). Best Regards Mayur PATIENT

Dr. Aanchal Maheshwari

Ayurveda

Case has to be correlated with Ayurveda, for this case has to be seen in person before starting the treatment as correlation of case with Ayurveda need to be done

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Nintedanib. Ridgefield, Connecticut: Boehringer Ingelheim Pharmaceuticals, Inc.; 2014. [Accessed 26 Mar. 2019] (online) Available from:
Nintedanib esilate. Bracknell, Berkshire: Boehringer Ingelheim Limited; 2015 [revised 31 Oct. 2018]. [Accessed 26 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). Nintedanib. [Accessed 26 Mar. 2019] (online) Available from:
CiplaMed. Nintedanib [Prescribing Information]. [last Revised: 19 Mar. 2021]. [Accessed 02 Aug. 2023] (online) Available from:

Marketer details

Name: Macleods Pharmaceuticals Pvt Ltd

Address: Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.

Country of origin: India

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