Ondeset Oral Solution is a medicine given to children to help treat nausea and vomiting. It is mainly given to treat nausea and vomiting associated with surgery, chemotherapy, radiotherapy, and stomach/intestinal infection. It also helps treat vomiting that is caused as a side effect of medicines like painkillers.

Ondeset Oral Solution may be given before or after meals. To control vomiting caused due to chemotherapy, give this medicine to your child 30 minutes before the procedure. Give it 1 to 2 hours before a radiotherapy session and 1 hour before surgery to prevent your child from vomiting post these procedures. If your child expels out the medicine within 30 minutes of the intake, help your child calm down and repeat the dose. Do not double dose if it is already time for the next dose.

Ondeset Oral Solution may cause some temporary side effects such as headache, constipation, diarrhea, and fatigue. These side effects usually subside once your child’s body adapts to the medicine. In case these side effects persist or become bothersome, do reach out to the doctor on a priority basis.

Let the doctor know about all the medicines your child is taking, including painkillers, antibiotics, or medicines taken to treat depression. Also, inform the doctor if your child has a history of liver problems, kidney malfunction, blockage in the gastrointestinal tract, heart problems, or allergies to any medicine, its ingredients, or a food product. This information is very important for dose alterations and for planning your child’s overall treatment.

Uses of Ondeset Oral Solution in children

Side effects of Ondeset Oral Solution in children

Ondeset Oral Solution does not pose serious side effects and is well-tolerated by children. In case the side effects do occur, they’re likely to subside once the body adapts to the medicine. Consult your child’s doctor if these side effects persist or bother your child. The most common side effects include-

Common side effects of Ondeset

Constipation
Diarrhea
Fatigue
Headache

How can I give Ondeset Oral Solution to my child?

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Ondeset Oral Solution may be taken with or without food, but it is better to take it at a fixed time.

How Ondeset Oral Solution works

During radiotherapy, chemotherapy, abdominal infection, or any major surgeries, the dead cells in the body start releasing a chemical called serotonin directly into the blood. Later, this stimulates special centers in the body that are responsible for inducing vomiting in your child. Giving Ondeset Oral Solution just before the procedure helps block the effect of this chemical on vomiting centers of the brain and prevents vomiting.

Safety advice

Kidney

SAFE IF PRESCRIBED

Ondeset Oral Solution is safe to use in patients with kidney disease. No dose adjustment of Ondeset Oral Solution is recommended.

Liver

CAUTION

Ondeset Oral Solution should be used with caution in patients with liver disease. Dose adjustment of Ondeset Oral Solution may be needed. Please consult your doctor.
In severe liver disease, do not exceed the prescribed dose and consult your child’s doctor.

What if I forget to give Ondeset Oral Solution to my child?

Do not panic. Give the missed dose as soon as you remember. However, you must skip the missed dose if it’s almost time for the next dose. Do not give a double dose and follow the prescribed dosing schedule.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

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Quick tips

Ondeset Oral Solution effectively controls nausea and bouts of vomiting reflex in children undergoing chemotherapy or radiotherapy sessions.
It is fast-acting and starts working within 30 minutes.
Practice self-care measures:
1. Give plenty of fluids to your child to avoid dehydration
2. Avoid giving fried and spicy food or heavy meals to your child.
3. Ensure that your child eats slowly and in small proportions.

Fact Box

Chemical Class

Carbazole Derivative

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

Serotonin 5-HT3 Receptor Antagonists

Interaction with drugs

Taking Ondeset with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Fluconazole (Oral Route) Life-threatening

Concomitant use may affect heart rhythm and may be fatal. Do not consume Fluconazole with Ondansetron.

Domperidone (Oral Route) Life-threatening

Concomitant use may affect heart rhythm and can be fatal. Do not consume Domperidone with Ondansetron.

Hydroxyzine (Oral Route) Life-threatening

Concomitant use may affect heart rhythm and may be fatal. Do not consume Hydroxyzine with Ondansetron.

Voriconazole (Oral Route) Life-threatening

Concomitant use may affect heart rhythm and may be fatal. Do not consume Voriconazole with Ondansetron.

Efavirenz (Oral Route) Life-threatening

Concomitant use may affect heart rhythm and may be fatal. Do not consume Efavirenz with Ondansetron.

View all drug interactions

Patient concerns

What is side effect of primolut n

Dr. Megha Tuli

Obstetrics and Gynaecology

Bloating, pain abdomen, nausea, vomiting etc are common side of Primolut.

Vomiting, nausea neck pain backside

Dr. Vijay Verma

ENT

Neck pain may be due to nausea NAD vomiting Visit physician for the same

Vomiting nausea problem and fever

Dr. Gopal Bansilal Samdani

Paediatrics

Monitor temperature of Patient. If Patient has fever place a cool, damp washcloth on your child's forehead. Give your Patient a lukewarm tub bath or a sponge bath. Give a sponge bath as follows: - ? Use lukewarm water [90?F (32.2?C) to 95?F (35?C)]. Do not use cold water, ice, or rubbing alcohol, which will lower the child's body temperature too quickly. ? Sponge for 20 to 30 minutes. ? Stop if the child starts to shiver. If your child doesn't like the sponge bath or doesn't feel better after the bath, there is no need to give another one. You can use paracetamol also along with above measures to control fever till you consult Dr. will determine underlying disorders by clinical examination which range from mild conditions to the most serious of bacterial and viral illnesses and will prescribe medicines accordingly. Advice given without doing clinical examination can be imperfect or some time harmful to patient.

FAQs

What is Ondeset Oral Solution used for?

Ondeset Oral Solution is generally given before any major surgery or before chemotherapy and radiotherapy sessions. In case your child is about to undergo any of the above procedures, the doctor may ask you to give Ondeset Oral Solution to your child to prevent vomiting post-procedure. Apart from this, Ondeset Oral Solution is also found useful in treating vomiting caused due to diseases of the stomach. In such a case, your child’s doctor may prescribe giving Ondeset Oral Solution to your child for a few days. Stick to the dose for best results.

What if my child takes too much Ondeset Oral Solution?

Ondeset Oral Solution is unlikely to cause harm if you give an extra dose by mistake. However, you must still speak to your child’s doctor immediately. Sometimes, excessive intake of Ondeset Oral Solution can cause some serious side effects like excess sleepiness, agitation, rapid heartbeat, hypertension, flushing, dilated pupils, sweating, involuntary muscle jerk, uncontrolled eye movements, overactive reflexes, and seizures. These symptoms are collectively known as serotonin syndrome. If any of these appear, consult the doctor without any delay.

How should Ondeset Oral Solution be stored?

Ondeset Oral Solution should be stored at room temperature, in a dry place, away from direct heat and light. Also, keep all the medicines out of the reach and sight of children to avoid any accidental intake.

Can other medicines be given at the same time as Ondeset Oral Solution?

Ondeset Oral Solution can sometimes interact with other medicines or substances. Tell your doctor about any other medicines your child is taking before starting Ondeset Oral Solution. Also, check with your child’s doctor before giving any medicine to your child.

In what conditions do I need to call my child’s doctor right away?

Call your child’s doctor immediately if your child develops symptoms of serotonin syndrome like irregular heartbeat, green-colored vomiting, inability to pass wind, pale skin and eyes, dark-colored urine, restlessness, and insomnia.

My child is having a migraine and is on medication. Can I give Ondeset Oral Solution along with it?

Avoid combining Ondeset Oral Solution with such medicines because concomitant use of Ondeset Oral Solution with medicines meant to treat depression or migraine results in serotonin syndrome. Consult your child’s doctor before giving any medicine to your child.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Sharkey KA, Wallace JL. Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1341-42.
Katzung BG. Histamine, Serotonin, & the Ergot Alkaloids. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 285
Ondansetron hydrochloride [FDA Label]. Research Triangle Park, NC: GlaxoSmithKline; 2016. [Accessed 04 Jan. 2020] (online) Available from:
Children’s Minnesota. Patient & Family Education Materials: Ondansetron (Zofran). [Accessed 04 Jan. 2020] (online) Available from:
Ondansetron [Summary of Product Characteristics]. Solan, Himachal Pradesh: Cachet Pharmaceuticals PVT. LTD.; 2024. [Accessed 25 Jul. 2024] (online) Available from:

Marketer details

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Country of origin: India
Expires on or after: March, 2025

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